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GSE58827: Dynamics of the Mouse Liver
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Results for Hoxa13
Z-value: 2.31
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Transcription factors associated with Hoxa13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxa13 | mm39_v1_chr6_-_52237765_52237788 | -0.02 | 8.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxa13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 55.6 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 3.6 | 43.2 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 9.3 | 37.4 | GO:0034760 | negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760) |
| 3.0 | 33.0 | GO:0042436 | tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) |
| 1.3 | 21.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 6.1 | 18.4 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 1.0 | 16.7 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 2.6 | 15.6 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 15.2 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.8 | 15.1 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 21.4 | GO:0044218 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.2 | 19.8 | GO:0005811 | lipid particle(GO:0005811) |
| 1.0 | 15.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.2 | 15.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.8 | 14.2 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 13.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 10.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 10.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 2.0 | 10.0 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 9.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 41.3 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
| 0.2 | 29.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.3 | 26.1 | GO:0005550 | pheromone binding(GO:0005550) |
| 8.5 | 25.6 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 8.1 | 24.2 | GO:0005009 | insulin-activated receptor activity(GO:0005009) |
| 5.3 | 21.3 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 0.1 | 20.2 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 1.1 | 17.8 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.4 | 16.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 15.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 15.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 13.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 9.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 7.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 5.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 5.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 3.6 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 3.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 33.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.3 | 24.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.7 | 21.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 19.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 12.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.3 | 9.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.7 | 9.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 9.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.6 | 7.6 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.4 | 7.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |