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GSE58827: Dynamics of the Mouse Liver
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Results for Hoxa2
Z-value: 1.87
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Transcription factors associated with Hoxa2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxa2 | mm39_v1_chr6_-_52141796_52141816 | -0.41 | 1.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_61972348 Show fit | 25.25 |
ENSMUST00000074018.4
|
major urinary protein 20 |
|
| chr4_+_63262775 Show fit | 23.91 |
ENSMUST00000030044.3
|
orosomucoid 1 |
|
| chr7_+_26819334 Show fit | 18.48 |
ENSMUST00000003100.10
|
cytochrome P450, family 2, subfamily f, polypeptide 2 |
|
| chr5_-_87572060 Show fit | 16.03 |
ENSMUST00000072818.6
|
UDP glucuronosyltransferase 2 family, polypeptide B38 |
|
| chr19_+_20470056 Show fit | 15.28 |
ENSMUST00000225337.3
|
aldehyde dehydrogenase family 1, subfamily A1 |
|
| chr19_-_8382424 Show fit | 15.27 |
ENSMUST00000064507.12
ENSMUST00000120540.2 ENSMUST00000096269.11 |
solute carrier family 22, member 30 |
|
| chr4_-_62069046 Show fit | 13.58 |
ENSMUST00000077719.4
|
major urinary protein 21 |
|
| chr7_-_46392403 Show fit | 12.36 |
ENSMUST00000128088.4
|
serum amyloid A 1 |
|
| chr4_-_107975701 Show fit | 11.86 |
ENSMUST00000149106.8
|
sterol carrier protein 2, liver |
|
| chr2_+_102536701 Show fit | 11.14 |
ENSMUST00000123759.8
ENSMUST00000005220.11 ENSMUST00000111212.8 |
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxa2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 61.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 4.2 | 25.3 | GO:0008355 | olfactory learning(GO:0008355) |
| 2.8 | 25.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 1.4 | 20.5 | GO:0015747 | urate transport(GO:0015747) |
| 0.3 | 19.6 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 4.7 | 18.8 | GO:0032385 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
| 6.2 | 18.5 | GO:0018931 | naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420) |
| 1.0 | 17.8 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 2.6 | 15.4 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.4 | 14.4 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 78.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.1 | 43.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 2.2 | 17.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 1.3 | 17.5 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 16.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 13.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 13.5 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 11.2 | GO:0030673 | axolemma(GO:0030673) |
| 2.0 | 10.0 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.0 | 8.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 53.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.8 | 26.0 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 5.1 | 25.3 | GO:0005186 | pheromone activity(GO:0005186) |
| 5.0 | 25.1 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 1.2 | 20.1 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.8 | 19.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 4.9 | 19.5 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 4.7 | 18.8 | GO:0033814 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
| 0.4 | 18.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.8 | 16.8 | GO:0070513 | death domain binding(GO:0070513) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 9.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 8.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 6.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 2.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 2.3 | 25.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.0 | 23.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.2 | 23.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 14.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 12.4 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 10.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 9.7 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 6.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 5.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |