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GSE58827: Dynamics of the Mouse Liver
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Results for Hoxb7
Z-value: 2.27
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | mm39_v1_chr11_+_96177449_96177480 | -0.19 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_150341911 Show fit | 13.49 |
ENSMUST00000162367.8
ENSMUST00000161611.8 ENSMUST00000161320.8 ENSMUST00000159035.2 |
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
|
| chrM_+_5319 Show fit | 10.52 |
ENSMUST00000082402.1
|
mitochondrially encoded cytochrome c oxidase I |
|
| chr19_+_39275518 Show fit | 10.43 |
ENSMUST00000003137.15
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr3_+_59989282 Show fit | 8.24 |
ENSMUST00000029326.6
|
succinate receptor 1 |
|
| chr10_+_87695117 Show fit | 8.21 |
ENSMUST00000105300.9
|
insulin-like growth factor 1 |
|
| chr19_+_26582450 Show fit | 8.18 |
ENSMUST00000176769.9
ENSMUST00000208163.2 ENSMUST00000025862.15 ENSMUST00000176030.8 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
|
| chr7_+_51537645 Show fit | 7.64 |
ENSMUST00000208711.2
|
growth arrest specific 2 |
|
| chr1_+_127657142 Show fit | 7.64 |
ENSMUST00000038006.8
|
amino carboxymuconate semialdehyde decarboxylase |
|
| chr15_+_6474808 Show fit | 7.33 |
ENSMUST00000022749.17
ENSMUST00000239466.2 |
complement component 9 |
|
| chr10_+_87694924 Show fit | 7.03 |
ENSMUST00000095360.11
|
insulin-like growth factor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 25.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 3.4 | 23.5 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.4 | 22.4 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 1.9 | 15.1 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.3 | 14.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.5 | 13.5 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.5 | 13.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 1.0 | 11.6 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.4 | 11.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 1.8 | 11.1 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 2.4 | 23.5 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 2.6 | 23.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 20.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 19.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 19.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.6 | 14.1 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 12.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 11.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.6 | 11.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 29.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 21.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.5 | 21.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.6 | 18.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 15.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.4 | 15.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.5 | 14.7 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 2.2 | 13.2 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.1 | 12.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 2.9 | 11.6 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 33.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.4 | 32.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 13.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 12.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 10.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 10.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 8.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 6.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.8 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 33.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.3 | 27.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 15.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.9 | 13.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 11.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 11.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 8.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 8.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 8.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 7.9 | REACTOME RNA POL III TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |