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GSE58827: Dynamics of the Mouse Liver
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Results for Id4
Z-value: 2.74
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Transcription factors associated with Id4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Id4 | mm39_v1_chr13_+_48414582_48414704 | -0.10 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_30623592 Show fit | 35.67 |
ENSMUST00000217812.2
ENSMUST00000074671.9 |
hepcidin antimicrobial peptide 2 |
|
| chr16_-_17906886 Show fit | 22.59 |
ENSMUST00000132241.2
ENSMUST00000139861.2 ENSMUST00000003620.13 |
proline dehydrogenase |
|
| chr15_-_98575332 Show fit | 20.62 |
ENSMUST00000120997.2
ENSMUST00000109149.9 ENSMUST00000003451.11 |
Rho family GTPase 1 |
|
| chr4_+_133280680 Show fit | 20.28 |
ENSMUST00000042706.3
|
nuclear receptor subfamily 0, group B, member 2 |
|
| chr15_+_76582372 Show fit | 18.83 |
ENSMUST00000229140.2
|
glutamic pyruvic transaminase, soluble |
|
| chr10_+_87695352 Show fit | 18.07 |
ENSMUST00000121952.8
ENSMUST00000126490.8 |
insulin-like growth factor 1 |
|
| chr11_-_5900019 Show fit | 15.49 |
ENSMUST00000102920.4
|
glucokinase |
|
| chr10_-_128796834 Show fit | 15.31 |
ENSMUST00000026398.5
|
methyltransferase like 7B |
|
| chr7_+_43856724 Show fit | 15.07 |
ENSMUST00000077354.5
|
kallikrein 1-related pepidase b4 |
|
| chr11_+_72326391 Show fit | 14.80 |
ENSMUST00000100903.3
|
gamma-glutamyltransferase 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Id4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 41.5 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 12.4 | 37.1 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 8.9 | 35.7 | GO:0034760 | negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760) |
| 2.6 | 29.0 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 7.1 | 28.4 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 9.4 | 28.1 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.5 | 25.3 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 3.6 | 24.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 1.7 | 23.6 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 3.3 | 23.0 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 64.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 53.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 4.3 | 42.5 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.2 | 36.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 3.6 | 32.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.6 | 29.6 | GO:0030673 | axolemma(GO:0030673) |
| 1.0 | 29.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 28.6 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.3 | 22.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.9 | 22.7 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 47.6 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 1.0 | 44.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 1.5 | 37.8 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 34.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 5.3 | 31.9 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.3 | 31.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 30.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 7.2 | 29.0 | GO:0047016 | cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016) |
| 0.7 | 28.1 | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645) |
| 1.0 | 24.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 49.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.5 | 41.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.6 | 34.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 1.0 | 20.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 15.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 14.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 14.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 13.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 12.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 12.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 70.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 65.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.6 | 47.6 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.8 | 38.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 2.3 | 33.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.4 | 30.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.1 | 22.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 1.6 | 20.8 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 1.0 | 20.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.6 | 20.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |