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GSE58827: Dynamics of the Mouse Liver
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Results for Klf1
Z-value: 2.52
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Transcription factors associated with Klf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf1 | mm39_v1_chr8_+_85628557_85628621 | 0.83 | 4.2e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 51.4 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 6.6 | 39.7 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 1.6 | 31.6 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 3.8 | 30.1 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 1.4 | 27.4 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 1.4 | 26.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 2.2 | 26.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 1.5 | 25.8 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 24.1 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.6 | 23.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 42.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 5.9 | 41.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 1.7 | 37.1 | GO:0042581 | specific granule(GO:0042581) |
| 1.2 | 31.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 6.1 | 30.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.9 | 29.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.4 | 28.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 25.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.3 | 24.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.4 | 23.8 | GO:0090543 | Flemming body(GO:0090543) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 85.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 1.4 | 69.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 37.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 32.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 31.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 7.7 | 30.7 | GO:0031720 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 0.2 | 28.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.2 | 26.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 2.5 | 24.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 24.3 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 31.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 24.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 2.7 | 24.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.4 | 23.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 1.0 | 22.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.3 | 18.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.2 | 17.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.9 | 17.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 17.4 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 53.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.9 | 45.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.6 | 31.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.3 | 30.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.9 | 26.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 24.8 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.4 | 23.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 19.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.8 | 17.2 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.3 | 16.6 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |