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GSE58827: Dynamics of the Mouse Liver
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Results for Klf16_Sp8
Z-value: 2.39
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Transcription factors associated with Klf16_Sp8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf16 | mm39_v1_chr10_-_80413119_80413161 | -0.90 | 8.6e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf16_Sp8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 70.6 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.9 | 64.6 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 1.1 | 57.5 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 1.6 | 47.7 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 4.6 | 46.3 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) |
| 0.9 | 40.2 | GO:0001702 | gastrulation with mouth forming second(GO:0001702) |
| 9.8 | 39.4 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 3.8 | 38.5 | GO:0061727 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 6.1 | 36.7 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 5.8 | 34.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 415.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 244.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.9 | 205.0 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 156.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 116.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 111.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 88.8 | GO:0043235 | receptor complex(GO:0043235) |
| 2.2 | 66.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 8.2 | 65.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 3.7 | 48.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 60.0 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.5 | 57.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 2.3 | 49.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 1.8 | 46.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 44.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 14.6 | 43.9 | GO:0016855 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.6 | 40.1 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 6.5 | 39.2 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.7 | 38.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 4.7 | 37.5 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 49.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.2 | 43.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.7 | 40.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 35.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 31.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.8 | 30.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.8 | 30.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 29.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 21.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 20.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 164.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 100.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 2.8 | 82.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 2.9 | 71.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 2.8 | 69.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 1.9 | 64.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 1.8 | 55.8 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.7 | 47.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.7 | 45.4 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 4.1 | 44.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |