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GSE58827: Dynamics of the Mouse Liver
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Results for Klf4_Sp3
Z-value: 3.40
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Transcription factors associated with Klf4_Sp3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp3 | mm39_v1_chr2_-_72810782_72810811 | 0.74 | 2.6e-07 | Click! |
| Klf4 | mm39_v1_chr4_-_55532453_55532485 | 0.63 | 3.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf4_Sp3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 185.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 8.0 | 96.1 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 4.7 | 93.5 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 2.4 | 78.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 7.3 | 73.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 1.5 | 71.3 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
| 0.4 | 68.9 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 1.0 | 63.3 | GO:0070527 | platelet aggregation(GO:0070527) |
| 5.7 | 62.9 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 10.4 | 62.7 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 147.8 | GO:0000922 | spindle pole(GO:0000922) |
| 1.7 | 135.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.5 | 117.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 3.4 | 107.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 2.0 | 107.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.4 | 103.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.7 | 102.6 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 1.7 | 98.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.9 | 90.9 | GO:0005819 | spindle(GO:0005819) |
| 7.1 | 85.6 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 219.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.5 | 187.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.9 | 160.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 156.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.7 | 147.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.6 | 131.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.5 | 131.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.7 | 129.0 | GO:0042393 | histone binding(GO:0042393) |
| 3.2 | 123.8 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 1.7 | 97.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 206.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.2 | 186.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.6 | 144.4 | PID E2F PATHWAY | E2F transcription factor network |
| 2.1 | 125.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.2 | 125.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.6 | 124.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 5.5 | 104.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.7 | 92.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 1.2 | 83.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 1.8 | 78.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 232.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.7 | 133.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.9 | 109.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 2.7 | 107.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.4 | 104.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.9 | 93.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 4.1 | 91.2 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.4 | 87.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 6.6 | 85.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 1.7 | 85.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |