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GSE58827: Dynamics of the Mouse Liver
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Results for Maz_Zfp281
Z-value: 2.62
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Transcription factors associated with Maz_Zfp281
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Maz | mm39_v1_chr7_-_126625617_126625653 | 0.75 | 1.7e-07 | Click! |
| Zfp281 | mm39_v1_chr1_+_136552639_136552688 | 0.22 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Maz_Zfp281
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 65.1 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.9 | 56.1 | GO:0051693 | actin filament capping(GO:0051693) |
| 1.7 | 50.2 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 1.3 | 33.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 1.8 | 32.1 | GO:0043117 | positive regulation of vascular permeability(GO:0043117) |
| 5.1 | 30.6 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 10.1 | 30.2 | GO:0034118 | erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118) |
| 1.0 | 29.9 | GO:0072606 | interleukin-8 secretion(GO:0072606) |
| 1.6 | 29.2 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 7.2 | 28.8 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 3.7 | 40.5 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.3 | 39.8 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.6 | 36.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 4.5 | 31.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 1.1 | 30.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 29.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 28.7 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.7 | 28.6 | GO:0002102 | podosome(GO:0002102) |
| 0.8 | 27.8 | GO:0001891 | phagocytic cup(GO:0001891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 73.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.6 | 73.0 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.5 | 49.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 43.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.5 | 42.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 35.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 35.1 | GO:0003723 | RNA binding(GO:0003723) |
| 1.6 | 34.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.6 | 34.5 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 2.4 | 34.0 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 90.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.6 | 62.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.7 | 55.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.0 | 54.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.9 | 53.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 51.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.3 | 49.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.3 | 48.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 45.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.6 | 38.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 64.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.7 | 61.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 1.0 | 56.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.8 | 52.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 50.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.3 | 37.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 36.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.7 | 34.5 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.4 | 34.0 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.5 | 33.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |