ISMARA results: Mecp2

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GSE58827: Dynamics of the Mouse Liver

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Results for Mecp2

Z-value: 3.09

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Transcription factors associated with Mecp2

Gene Symbol	Gene ID	Gene Info
Mecp2 Ensembl NCBI MGI UniProt	ENSMUSG00000031393.17	methyl CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mecp2	mm39_v1_chrX_-_73129195_73129296	0.82	7.5e-10	Click!

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_76756772 Show fit	12.86	ENSMUST00000166101.2	Sptb Ensembl NCBI MGI UniProt Show fit	spectrin beta, erythrocytic
chr8_+_57964921 Show fit	8.74	ENSMUST00000067925.8	Hmgb2 Ensembl NCBI MGI UniProt Show fit	high mobility group box 2
chr8_+_57964956 Show fit	8.36	ENSMUST00000210871.2	Hmgb2 Ensembl NCBI MGI UniProt Show fit	high mobility group box 2
chr3_+_14951478 Show fit	8.31	ENSMUST00000029078.9	Car2 Ensembl NCBI MGI UniProt Show fit	carbonic anhydrase 2
chr3_+_14951264 Show fit	8.05	ENSMUST00000192609.6	Car2 Ensembl NCBI MGI UniProt Show fit	carbonic anhydrase 2
chr8_+_23464860 Show fit	7.91	ENSMUST00000110688.9 ENSMUST00000121802.9	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr17_-_7050145 Show fit	7.12	ENSMUST00000064234.7	Ezr Ensembl NCBI MGI UniProt Show fit	ezrin
chr4_+_120523758 Show fit	7.08	ENSMUST00000094814.6	Cited4 Ensembl NCBI MGI UniProt Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr18_-_67774399 Show fit	7.01	ENSMUST00000097542.4	Cep76 Ensembl NCBI MGI UniProt Show fit	centrosomal protein 76
chr14_-_69740670 Show fit	7.00	ENSMUST00000180059.3 ENSMUST00000179116.3	Gm16867 Ensembl NCBI MGI UniProt Show fit	predicted gene, 16867

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	41.7	GO:0051028	mRNA transport(GO:0051028)
0.4	31.8	GO:0002181	cytoplasmic translation(GO:0002181)
0.4	27.8	GO:0051225	spindle assembly(GO:0051225)
0.7	27.0	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.3	23.8	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
0.7	22.8	GO:0000470	maturation of LSU-rRNA(GO:0000470)
2.2	21.5	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
2.0	20.2	GO:0010032	meiotic chromosome condensation(GO:0010032)
4.3	17.4	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.5	16.8	GO:0060236	regulation of mitotic spindle organization(GO:0060236)

Showing 1 to 10 of 991 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	44.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.4	36.6	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.1	30.6	GO:0005694	chromosome(GO:0005694)
0.1	29.0	GO:0031965	nuclear membrane(GO:0031965)
0.0	28.0	GO:0005829	cytosol(GO:0005829)
0.1	26.3	GO:0016607	nuclear speck(GO:0016607)
0.2	24.6	GO:0016605	PML body(GO:0016605)
0.3	23.7	GO:0000922	spindle pole(GO:0000922)
0.3	22.3	GO:0000776	kinetochore(GO:0000776)
1.0	21.2	GO:0042405	nuclear inclusion body(GO:0042405)

Showing 1 to 10 of 405 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	79.0	GO:0003723	RNA binding(GO:0003723)
0.4	62.8	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	54.4	GO:0045296	cadherin binding(GO:0045296)
0.2	28.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	25.7	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.6	24.4	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.8	23.2	GO:0008143	poly(A) binding(GO:0008143)
0.3	23.2	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	22.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	21.0	GO:0042393	histone binding(GO:0042393)

Showing 1 to 10 of 627 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	69.9	PID AURORA B PATHWAY	Aurora B signaling
0.9	57.3	PID PLK1 PATHWAY	PLK1 signaling events
0.5	47.4	PID E2F PATHWAY	E2F transcription factor network
0.3	34.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.6	30.9	PID FANCONI PATHWAY	Fanconi anemia pathway
0.4	29.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	23.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	20.6	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.4	20.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	19.1	PID P53 REGULATION PATHWAY	p53 pathway

Showing 1 to 10 of 112 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	64.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	38.7	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	34.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.1	29.7	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
2.2	28.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.6	27.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.4	27.0	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
1.3	24.6	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	23.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.4	22.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening

Showing 1 to 10 of 186 entries

Results for Mecp2

Z-value: 3.09

Motif logo

Transcription factors associated with Mecp2

Activity-expression correlation:

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: