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GSE58827: Dynamics of the Mouse Liver
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Results for Mef2c
Z-value: 1.04
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Transcription factors associated with Mef2c
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | mm39_v1_chr13_+_83672389_83672411 | 0.46 | 4.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mef2c
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 29.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 1.1 | 10.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 9.4 | GO:0030239 | myofibril assembly(GO:0030239) |
| 1.3 | 7.7 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 0.1 | 7.6 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 2.5 | 7.5 | GO:0042694 | muscle cell fate specification(GO:0042694) |
| 0.5 | 4.5 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 1.0 | 4.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.4 | 3.9 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.2 | 3.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 30.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 16.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 15.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.5 | 11.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.7 | 9.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 2.9 | 8.7 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.4 | 6.0 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 3.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 3.7 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 3.7 | GO:0016528 | sarcoplasm(GO:0016528) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 18.0 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 16.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.6 | 16.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 9.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.8 | 9.0 | GO:0051373 | FATZ binding(GO:0051373) |
| 1.8 | 7.1 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.4 | 6.0 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.5 | 4.5 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.0 | 4.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 3.3 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 3.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.4 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 57.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 9.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 4.5 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.2 | 3.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 3.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 1.7 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.1 | 1.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.6 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 1.4 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |