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GSE58827: Dynamics of the Mouse Liver
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Results for Meis2
Z-value: 0.80
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Transcription factors associated with Meis2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Meis2 | mm39_v1_chr2_-_115894993_115895080 | 0.09 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Meis2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.9 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.2 | 11.2 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.1 | 11.0 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 0.6 | 8.7 | GO:0019585 | uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585) cellular glucuronidation(GO:0052695) |
| 0.3 | 8.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 2.6 | 7.8 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 2.6 | 7.7 | GO:0097037 | heme export(GO:0097037) |
| 0.0 | 7.5 | GO:0006694 | steroid biosynthetic process(GO:0006694) |
| 1.5 | 6.0 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 0.9 | 5.6 | GO:0061760 | antifungal innate immune response(GO:0061760) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 22.5 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 20.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 15.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.5 | 11.9 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.5 | 7.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 2.6 | 7.7 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.0 | 7.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.7 | 6.0 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 5.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 18.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 14.7 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 7.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 7.2 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.3 | 5.6 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 5.4 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 5.4 | GO:0030414 | peptidase inhibitor activity(GO:0030414) |
| 0.3 | 5.3 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 0.6 | 5.1 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.2 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 6.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 6.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 6.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 6.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 5.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.2 | 3.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 2.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 2.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 2.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |