ISMARA results: Myb

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GSE58827: Dynamics of the Mouse Liver

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Results for Myb

Z-value: 3.20

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Transcription factors associated with Myb

Gene Symbol	Gene ID	Gene Info
Myb Ensembl NCBI MGI UniProt	ENSMUSG00000019982.16	myeloblastosis oncogene

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myb	mm39_v1_chr10_-_21036792_21036810	0.88	1.4e-12	Click!

Activity profile of Myb motif

Sorted Z-values of Myb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_86055018 Show fit	29.06	ENSMUST00000205034.3 ENSMUST00000203724.3	Add2 Ensembl NCBI MGI UniProt Show fit	adducin 2 (beta)
chr17_-_48758538 Show fit	28.81	ENSMUST00000024794.12	Tspo2 Ensembl NCBI MGI UniProt Show fit	translocator protein 2
chr3_+_146110387 Show fit	27.88	ENSMUST00000106151.8 ENSMUST00000106153.9 ENSMUST00000039021.11 ENSMUST00000106149.8 ENSMUST00000149262.8	Ssx2ip Ensembl NCBI MGI UniProt Show fit	synovial sarcoma, X 2 interacting protein
chr10_+_79715448 Show fit	23.90	ENSMUST00000006679.15	Prtn3 Ensembl NCBI MGI UniProt Show fit	proteinase 3
chr6_+_86055048 Show fit	23.69	ENSMUST00000032069.8	Add2 Ensembl NCBI MGI UniProt Show fit	adducin 2 (beta)
chr4_-_118294521 Show fit	22.96	ENSMUST00000006565.13	Cdc20 Ensembl NCBI MGI UniProt Show fit	cell division cycle 20
chr11_+_87684299 Show fit	21.19	ENSMUST00000020779.11	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr6_-_125168637 Show fit	20.45	ENSMUST00000043848.11	Ncapd2 Ensembl NCBI MGI UniProt Show fit	non-SMC condensin I complex, subunit D2
chr6_+_124806506 Show fit	20.04	ENSMUST00000150120.8	Cdca3 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 3
chr6_+_124806541 Show fit	19.52	ENSMUST00000024270.14	Cdca3 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Myb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	52.7	GO:0051016	barbed-end actin filament capping(GO:0051016)
2.3	43.4	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
6.0	42.3	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
12.4	37.2	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
3.6	36.3	GO:0010032	meiotic chromosome condensation(GO:0010032)
1.4	32.5	GO:0022027	interkinetic nuclear migration(GO:0022027)
4.0	32.3	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
5.8	29.2	GO:0035617	stress granule disassembly(GO:0035617)
9.3	28.0	GO:0045763	negative regulation of cellular amino acid metabolic process(GO:0045763)
0.1	27.9	GO:0044772	mitotic cell cycle phase transition(GO:0044772)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	76.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
3.5	52.7	GO:0008290	F-actin capping protein complex(GO:0008290)
1.0	46.2	GO:0035371	microtubule plus-end(GO:0035371)
0.5	40.0	GO:0036126	sperm flagellum(GO:0036126)
0.5	38.5	GO:0005871	kinesin complex(GO:0005871)
1.1	37.4	GO:0034451	centriolar satellite(GO:0034451)
2.2	37.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
7.3	36.3	GO:0000799	nuclear condensin complex(GO:0000799)
0.3	32.1	GO:0005814	centriole(GO:0005814)
0.2	29.5	GO:0000776	kinetochore(GO:0000776)

Showing 1 to 10 of 100 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	73.4	GO:0030507	spectrin binding(GO:0030507)
0.4	47.4	GO:0003777	microtubule motor activity(GO:0003777)
0.0	46.9	GO:0019904	protein domain specific binding(GO:0019904)
0.7	37.2	GO:0004601	peroxidase activity(GO:0004601)
2.3	35.0	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.1	34.7	GO:0042393	histone binding(GO:0042393)
0.3	34.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.1	31.8	GO:0008143	poly(A) binding(GO:0008143)
2.0	28.2	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.4	27.8	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)

Showing 1 to 10 of 125 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	92.6	PID AURORA B PATHWAY	Aurora B signaling
0.4	41.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.7	40.0	PID PLK1 PATHWAY	PLK1 signaling events
0.6	37.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.7	31.1	PID AURORA A PATHWAY	Aurora A signaling
0.5	26.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.6	24.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
1.1	23.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.6	18.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.5	17.7	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	44.2	REACTOME KINESINS	Genes involved in Kinesins
0.4	42.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.5	26.5	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
1.2	24.4	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.5	21.9	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.5	21.8	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.2	18.8	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6	17.7	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.7	17.6	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.1	16.9	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway

Showing 1 to 10 of 49 entries

Results for Myb

Z-value: 3.20

Motif logo

Transcription factors associated with Myb

Activity-expression correlation:

Activity profile of Myb motif

Sorted Z-values of Myb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Myb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: