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GSE58827: Dynamics of the Mouse Liver
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Results for Myf6
Z-value: 4.41
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Transcription factors associated with Myf6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Myf6 | mm39_v1_chr10_-_107330580_107330603 | -0.18 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Myf6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 116.9 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 12.9 | 90.1 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 4.8 | 53.3 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 8.7 | 43.6 | GO:0002485 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485) |
| 1.6 | 37.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.2 | 37.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 1.8 | 35.5 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 10.3 | 30.9 | GO:0018931 | naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420) |
| 4.7 | 28.2 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.2 | 27.9 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 90.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 4.1 | 57.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 17.8 | 53.3 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.0 | 36.3 | GO:0005615 | extracellular space(GO:0005615) |
| 2.3 | 36.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 4.3 | 34.0 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 33.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.7 | 25.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 22.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 17.7 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 86.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 3.9 | 65.6 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 18.5 | 55.4 | GO:0005009 | insulin-activated receptor activity(GO:0005009) |
| 17.8 | 53.3 | GO:0004903 | growth hormone receptor activity(GO:0004903) |
| 1.8 | 46.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 33.8 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.4 | 32.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 1.2 | 30.9 | GO:0019825 | oxygen binding(GO:0019825) |
| 1.4 | 26.0 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.6 | 25.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 83.8 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.6 | 51.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.6 | 31.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 26.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 24.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 1.1 | 22.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 17.9 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 1.0 | 17.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 14.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 14.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 70.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 51.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.6 | 45.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 2.5 | 37.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.7 | 23.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 1.7 | 17.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 14.0 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.6 | 13.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 13.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 11.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |