ISMARA results: Myod1

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GSE58827: Dynamics of the Mouse Liver

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Results for Myod1

Z-value: 1.50

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Transcription factors associated with Myod1

Gene Symbol	Gene ID	Gene Info
Myod1 Ensembl NCBI MGI UniProt	ENSMUSG00000009471.5	myogenic differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myod1	mm39_v1_chr7_+_46025890_46025904	0.65	2.0e-05	Click!

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_23629080 Show fit	20.37	ENSMUST00000033947.15	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr8_+_23629046 Show fit	15.54	ENSMUST00000121075.8	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr1_-_132318039 Show fit	13.05	ENSMUST00000132435.2	Tmcc2 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 2
chr17_+_37180437 Show fit	12.90	ENSMUST00000060524.11	Trim10 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 10
chr7_-_142223662 Show fit	10.51	ENSMUST00000228850.2	Gm49394 Ensembl NCBI MGI UniProt Show fit	predicted gene, 49394
chr7_+_141995545 Show fit	10.23	ENSMUST00000105971.8 ENSMUST00000145287.8	Tnni2 Ensembl NCBI MGI UniProt Show fit	troponin I, skeletal, fast 2
chr6_-_125471666 Show fit	9.83	ENSMUST00000032492.9	Cd9 Ensembl NCBI MGI UniProt Show fit	CD9 antigen
chr7_+_126810780 Show fit	9.71	ENSMUST00000032910.13	Mylpf Ensembl NCBI MGI UniProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr12_-_76756772 Show fit	9.30	ENSMUST00000166101.2	Sptb Ensembl NCBI MGI UniProt Show fit	spectrin beta, erythrocytic
chr12_+_109425769 Show fit	9.04	ENSMUST00000173812.2	Dlk1 Ensembl NCBI MGI UniProt Show fit	delta like non-canonical Notch ligand 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	44.9	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.8	21.2	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.4	18.8	GO:0003009	skeletal muscle contraction(GO:0003009)
0.6	15.8	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.9	14.8	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	14.5	GO:0006936	muscle contraction(GO:0006936)
0.8	12.6	GO:0048194	Golgi vesicle budding(GO:0048194)
0.5	12.2	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.5	11.2	GO:0048368	lateral mesoderm development(GO:0048368)
2.1	10.7	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)

Showing 1 to 10 of 207 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	42.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.3	22.4	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.1	20.9	GO:0005861	troponin complex(GO:0005861)
1.3	19.4	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.3	18.5	GO:0031672	A band(GO:0031672)
0.0	18.2	GO:0009897	external side of plasma membrane(GO:0009897)
1.4	15.8	GO:0097451	glial limiting end-foot(GO:0097451)
0.1	12.1	GO:0016459	myosin complex(GO:0016459)
2.8	11.2	GO:0071149	TEAD-2-YAP complex(GO:0071149)
3.3	9.8	GO:0042643	actomyosin, actin portion(GO:0042643)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	44.5	GO:0008307	structural constituent of muscle(GO:0008307)
3.4	34.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.4	22.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2	16.2	GO:0050840	extracellular matrix binding(GO:0050840)
1.4	14.3	GO:0031014	troponin T binding(GO:0031014)
1.3	12.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.5	11.2	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.3	10.7	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3	10.5	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	10.5	GO:0005178	integrin binding(GO:0005178)

Showing 1 to 10 of 151 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	19.4	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	13.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	11.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	11.0	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	9.3	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.5	8.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.3	8.6	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.1	6.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4	5.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	54.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.8	42.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	22.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	15.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	14.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	10.7	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	10.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	10.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.6	8.7	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.4	8.6	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions

Showing 1 to 10 of 63 entries

Results for Myod1

Z-value: 1.50

Motif logo

Transcription factors associated with Myod1

Activity-expression correlation:

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: