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GSE58827: Dynamics of the Mouse Liver
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Results for Nfatc2
Z-value: 1.34
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Transcription factors associated with Nfatc2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc2 | mm39_v1_chr2_-_168432235_168432308 | 0.60 | 9.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_83421333 Show fit | 5.70 |
ENSMUST00000035938.3
|
chemokine (C-C motif) ligand 5 |
|
| chr12_-_101784727 Show fit | 4.85 |
ENSMUST00000222587.2
|
fibulin 5 |
|
| chr16_+_44913974 Show fit | 3.98 |
ENSMUST00000099498.10
|
coiled-coil domain containing 80 |
|
| chr11_-_99383938 Show fit | 3.68 |
ENSMUST00000006969.8
|
keratin 23 |
|
| chr1_+_51328265 Show fit | 3.50 |
ENSMUST00000051572.8
|
caveolae associated 2 |
|
| chr7_-_110462446 Show fit | 3.40 |
ENSMUST00000033050.5
|
lymphatic vessel endothelial hyaluronan receptor 1 |
|
| chr5_+_65505657 Show fit | 2.64 |
ENSMUST00000031096.11
|
klotho beta |
|
| chr11_-_11987391 Show fit | 2.55 |
ENSMUST00000093321.12
|
growth factor receptor bound protein 10 |
|
| chr12_-_101785307 Show fit | 2.42 |
ENSMUST00000021603.9
|
fibulin 5 |
|
| chr3_-_116762617 Show fit | 2.38 |
ENSMUST00000143611.2
ENSMUST00000040097.14 |
palmdelphin |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfatc2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.5 | 6.0 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.1 | 4.7 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.0 | 4.2 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 4.1 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 4.0 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 3.9 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 3.6 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 3.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 3.5 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 7.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 6.4 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 6.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 5.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 5.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 4.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 4.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 3.8 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 3.3 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 2.0 | 6.0 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.2 | 4.9 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.0 | 4.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 4.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 4.0 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 4.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 3.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 3.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.0 | 3.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 9.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 4.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 4.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.6 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 5.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 5.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 5.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 4.1 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 3.6 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 3.3 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |