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GSE58827: Dynamics of the Mouse Liver
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Results for Nfatc3
Z-value: 1.38
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Transcription factors associated with Nfatc3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc3 | mm39_v1_chr8_+_106786190_106786265 | -0.26 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_58658779 Show fit | 16.55 |
ENSMUST00000057270.9
|
pancreatic lipase |
|
| chr19_+_58658838 Show fit | 14.32 |
ENSMUST00000238108.2
|
pancreatic lipase |
|
| chr15_+_9335636 Show fit | 10.91 |
ENSMUST00000072403.7
|
UDP glycosyltransferases 3 family, polypeptide A2 |
|
| chr1_-_180021218 Show fit | 10.10 |
ENSMUST00000159914.8
|
coenzyme Q8A |
|
| chr15_+_76579885 Show fit | 9.87 |
ENSMUST00000231028.2
|
glutamic pyruvic transaminase, soluble |
|
| chr4_-_107164315 Show fit | 9.60 |
ENSMUST00000126291.2
ENSMUST00000106748.2 ENSMUST00000129138.2 |
deiodinase, iodothyronine, type I |
|
| chr15_+_10249646 Show fit | 8.61 |
ENSMUST00000134410.8
|
prolactin receptor |
|
| chr9_-_48516447 Show fit | 8.19 |
ENSMUST00000034808.12
ENSMUST00000119426.2 |
nicotinamide N-methyltransferase |
|
| chr19_-_7943365 Show fit | 7.90 |
ENSMUST00000182102.8
ENSMUST00000075619.5 |
solute carrier family 22, member 27 |
|
| chr14_+_40827108 Show fit | 7.14 |
ENSMUST00000224514.2
|
methionine adenosyltransferase I, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfatc3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 30.9 | GO:0061365 | positive regulation of triglyceride lipase activity(GO:0061365) |
| 6.0 | 17.9 | GO:0009087 | methionine catabolic process(GO:0009087) |
| 0.7 | 17.0 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 2.6 | 15.7 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.4 | 14.9 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 0.1 | 9.6 | GO:0042446 | hormone biosynthetic process(GO:0042446) |
| 1.0 | 9.3 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.6 | 9.3 | GO:0015747 | urate transport(GO:0015747) |
| 0.6 | 8.7 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.6 | 8.4 | GO:0006642 | triglyceride mobilization(GO:0006642) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 21.1 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 16.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 2.6 | 7.9 | GO:0034359 | mature chylomicron(GO:0034359) |
| 0.2 | 7.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.4 | 6.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.6 | 5.7 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 5.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 4.6 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 4.4 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 30.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.7 | 30.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 4.5 | 17.9 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 0.3 | 17.0 | GO:0043531 | ADP binding(GO:0043531) |
| 3.1 | 15.7 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 2.0 | 9.9 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 2.4 | 9.6 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.5 | 9.3 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.7 | 8.7 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 1.3 | 8.0 | GO:0008142 | oxysterol binding(GO:0008142) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 15.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 4.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.9 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 3.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 3.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.1 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.2 | 19.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.6 | 18.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.5 | 17.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 1.4 | 15.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.4 | 9.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.5 | 9.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.3 | 9.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 8.2 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.3 | 5.8 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |