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GSE58827: Dynamics of the Mouse Liver
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Results for Nfe2_Bach1_Mafk
Z-value: 1.24
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Transcription factors associated with Nfe2_Bach1_Mafk
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000058794.13 | nuclear factor, erythroid derived 2 | |
| ENSMUSG00000025612.6 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | |
| ENSMUSG00000018143.11 | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfe2 | mm39_v1_chr15_-_103163860_103163879 | -0.59 | 1.5e-04 | Click! |
| Mafk | mm39_v1_chr5_+_139777263_139777271 | -0.49 | 2.6e-03 | Click! |
| Bach1 | mm39_v1_chr16_+_87495792_87495872 | 0.03 | 8.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_86577940 Show fit | 23.25 |
ENSMUST00000034989.15
|
malic enzyme 1, NADP(+)-dependent, cytosolic |
|
| chr1_+_58069090 Show fit | 11.97 |
ENSMUST00000001027.7
|
aldehyde oxidase 1 |
|
| chr19_+_12610870 Show fit | 10.91 |
ENSMUST00000119960.2
|
glycine-N-acyltransferase |
|
| chr19_-_4087907 Show fit | 8.73 |
ENSMUST00000237982.2
|
glutathione S-transferase, pi 1 |
|
| chr19_-_4087940 Show fit | 8.61 |
ENSMUST00000237893.2
ENSMUST00000169613.4 |
glutathione S-transferase, pi 1 |
|
| chr19_-_4092218 Show fit | 8.27 |
ENSMUST00000237999.2
ENSMUST00000042700.12 |
glutathione S-transferase, pi 2 |
|
| chr19_+_12610668 Show fit | 7.57 |
ENSMUST00000044976.12
|
glycine-N-acyltransferase |
|
| chr6_+_129510331 Show fit | 6.89 |
ENSMUST00000204956.2
ENSMUST00000204639.2 |
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 |
|
| chr1_+_165596961 Show fit | 6.06 |
ENSMUST00000040298.5
|
cellular repressor of E1A-stimulated genes 1 |
|
| chr16_+_90017634 Show fit | 5.69 |
ENSMUST00000023707.11
|
superoxide dismutase 1, soluble |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfe2_Bach1_Mafk
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 23.3 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 5.8 | 17.3 | GO:2000469 | negative regulation of peroxidase activity(GO:2000469) |
| 0.1 | 13.0 | GO:0009636 | response to toxic substance(GO:0009636) |
| 1.2 | 12.9 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 2.4 | 12.0 | GO:0009115 | xanthine catabolic process(GO:0009115) |
| 0.7 | 10.6 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 9.1 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.5 | 7.7 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.2 | 6.0 | GO:0045821 | positive regulation of glycolytic process(GO:0045821) |
| 0.6 | 5.7 | GO:0019532 | oxalate transport(GO:0019532) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 25.6 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.5 | 19.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 12.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.6 | 7.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 5.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.2 | 5.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.5 | 4.5 | GO:0044753 | amphisome(GO:0044753) |
| 0.4 | 4.4 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 4.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 4.0 | GO:0000502 | proteasome complex(GO:0000502) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 25.6 | GO:0035731 | S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731) |
| 7.8 | 23.3 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 4.6 | 18.5 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 3.2 | 12.9 | GO:0047016 | cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016) |
| 2.5 | 12.6 | GO:0016623 | aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 0.5 | 10.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.2 | 6.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 6.1 | GO:0048037 | cofactor binding(GO:0048037) |
| 1.2 | 6.0 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.3 | 5.7 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 5.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 3.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.2 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 1.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 1.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 43.9 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 24.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.9 | 14.0 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 12.3 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.4 | 7.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 6.8 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 5.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 4.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 4.5 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 3.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |