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GSE58827: Dynamics of the Mouse Liver
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Results for Nfil3_Tef
Z-value: 2.73
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Transcription factors associated with Nfil3_Tef
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfil3 | mm39_v1_chr13_-_53135064_53135114 | 0.70 | 2.2e-06 | Click! |
| Tef | mm39_v1_chr15_+_81686622_81686779 | -0.01 | 9.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_26534730 Show fit | 39.68 |
ENSMUST00000005685.15
|
cytochrome P450, family 2, subfamily a, polypeptide 5 |
|
| chr14_+_66208498 Show fit | 36.97 |
ENSMUST00000128539.8
|
clusterin |
|
| chr14_+_66208613 Show fit | 32.96 |
ENSMUST00000144619.2
|
clusterin |
|
| chr14_+_66208253 Show fit | 32.82 |
ENSMUST00000138191.8
|
clusterin |
|
| chr14_+_66208059 Show fit | 30.61 |
ENSMUST00000127387.8
|
clusterin |
|
| chr8_-_93924426 Show fit | 25.25 |
ENSMUST00000034172.8
|
carboxylesterase 1D |
|
| chr16_+_22769822 Show fit | 23.58 |
ENSMUST00000023590.9
|
histidine-rich glycoprotein |
|
| chr16_+_22769844 Show fit | 23.02 |
ENSMUST00000232422.2
|
histidine-rich glycoprotein |
|
| chr5_-_92475927 Show fit | 22.64 |
ENSMUST00000113093.5
|
chemokine (C-X-C motif) ligand 9 |
|
| chr7_+_26006594 Show fit | 22.05 |
ENSMUST00000098657.5
|
cytochrome P450, family 2, subfamily a, polypeptide 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfil3_Tef
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.2 | 133.4 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 3.1 | 102.2 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 15.5 | 46.6 | GO:0097037 | heme export(GO:0097037) |
| 15.0 | 45.1 | GO:0009087 | methionine catabolic process(GO:0009087) |
| 0.4 | 39.8 | GO:0035383 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 1.1 | 26.6 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.9 | 25.9 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 8.4 | 25.3 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.8 | 22.3 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 2.4 | 21.5 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 133.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.6 | 53.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 47.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 15.5 | 46.6 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.3 | 45.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 36.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.1 | 26.6 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.4 | 25.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 20.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 16.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 133.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.7 | 61.1 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 11.3 | 45.1 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 1.5 | 42.2 | GO:0043295 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 5.0 | 40.3 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.2 | 34.4 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.3 | 34.3 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 3.8 | 26.6 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 3.2 | 25.5 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 8.4 | 25.3 | GO:0004771 | sterol esterase activity(GO:0004771) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 125.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 26.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 20.9 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.2 | 16.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.2 | 11.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 8.1 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 7.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 6.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 4.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 181.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.3 | 59.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.3 | 45.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 3.3 | 36.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.4 | 19.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 17.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.3 | 17.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 15.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 13.9 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.8 | 13.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |