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GSE58827: Dynamics of the Mouse Liver
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Results for Nkx3-1
Z-value: 1.90
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Transcription factors associated with Nkx3-1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx3-1 | mm39_v1_chr14_+_69428087_69428140 | 0.08 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_137157824 Show fit | 43.15 |
ENSMUST00000102522.5
|
chymotrypsin-like elastase family, member 3B |
|
| chr19_+_58748132 Show fit | 34.01 |
ENSMUST00000026081.5
|
pancreatic lipase-related protein 2 |
|
| chr6_-_41012435 Show fit | 33.78 |
ENSMUST00000031931.6
|
RIKEN cDNA 2210010C04 gene |
|
| chr6_+_78402956 Show fit | 30.29 |
ENSMUST00000079926.6
|
regenerating islet-derived 1 |
|
| chr3_-_113325938 Show fit | 23.38 |
ENSMUST00000132353.2
|
amylase 2a1 |
|
| chr3_-_113198765 Show fit | 19.06 |
ENSMUST00000179568.3
|
amylase 2a4 |
|
| chr3_-_113231368 Show fit | 17.63 |
ENSMUST00000179314.3
|
amylase 2a3 |
|
| chr3_-_113263974 Show fit | 17.24 |
ENSMUST00000098667.5
|
amylase 2a2 |
|
| chr3_-_113166153 Show fit | 17.14 |
ENSMUST00000098673.5
|
amylase 2a5 |
|
| chr4_-_137137088 Show fit | 15.83 |
ENSMUST00000024200.7
|
chymotrypsin-like elastase family, member 3A |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx3-1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 60.2 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
| 2.0 | 34.0 | GO:0019374 | galactolipid metabolic process(GO:0019374) |
| 1.8 | 30.3 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 25.7 | GO:0055114 | oxidation-reduction process(GO:0055114) |
| 1.7 | 6.7 | GO:0034031 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
| 0.2 | 6.4 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 5.2 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.4 | 4.2 | GO:0030242 | pexophagy(GO:0030242) |
| 1.3 | 4.0 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.3 | 3.3 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 100.9 | GO:0005615 | extracellular space(GO:0005615) |
| 1.6 | 64.3 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 49.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 20.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 16.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 13.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 6.4 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 5.8 | GO:0000800 | lateral element(GO:0000800) |
| 0.8 | 3.0 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.3 | 3.0 | GO:0097433 | dense body(GO:0097433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 91.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 10.2 | 71.1 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 2.1 | 34.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 30.3 | GO:0008083 | growth factor activity(GO:0008083) |
| 2.4 | 19.5 | GO:0050649 | testosterone 6-beta-hydroxylase activity(GO:0050649) |
| 1.4 | 10.0 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 1.3 | 6.7 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.1 | 4.0 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 3.7 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.3 | 3.6 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 69.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.4 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.2 | 5.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.3 | 5.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 2.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 2.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 2.2 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 2.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 1.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |