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GSE58827: Dynamics of the Mouse Liver
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Results for Nr1h2
Z-value: 2.12
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Transcription factors associated with Nr1h2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1h2 | mm39_v1_chr7_-_44203319_44203392 | -0.70 | 2.4e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_97066937 Show fit | 49.03 |
ENSMUST00000043077.8
|
thyroid hormone responsive |
|
| chr2_+_102488985 Show fit | 14.26 |
ENSMUST00000080210.10
|
solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
|
| chr3_+_146302832 Show fit | 13.49 |
ENSMUST00000029837.14
ENSMUST00000147409.2 ENSMUST00000121133.2 |
urate oxidase |
|
| chr11_-_60101235 Show fit | 13.44 |
ENSMUST00000144942.2
|
sterol regulatory element binding transcription factor 1 |
|
| chr17_-_84154173 Show fit | 12.66 |
ENSMUST00000000687.9
|
3-hydroxyanthranilate 3,4-dioxygenase |
|
| chr17_-_84154196 Show fit | 12.15 |
ENSMUST00000234214.2
|
3-hydroxyanthranilate 3,4-dioxygenase |
|
| chr11_-_120715351 Show fit | 11.44 |
ENSMUST00000055655.9
|
fatty acid synthase |
|
| chr6_-_119521243 Show fit | 10.88 |
ENSMUST00000119369.2
ENSMUST00000178696.8 |
wingless-type MMTV integration site family, member 5B |
|
| chr11_+_54988866 Show fit | 10.84 |
ENSMUST00000000608.8
|
GM2 ganglioside activator protein |
|
| chr12_+_112073261 Show fit | 10.29 |
ENSMUST00000223412.2
|
asparaginase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1h2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 49.0 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 2.8 | 24.8 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 4.2 | 16.7 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 2.0 | 14.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.4 | 13.8 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.6 | 13.5 | GO:0046415 | urate metabolic process(GO:0046415) |
| 1.5 | 13.4 | GO:0003062 | regulation of heart rate by chemical signal(GO:0003062) |
| 1.4 | 11.4 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.1 | 10.9 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 1.4 | 10.8 | GO:0009313 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.7 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.1 | 31.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 16.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 14.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 14.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 12.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.0 | 11.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.3 | 10.4 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 10.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.2 | 9.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.1 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 1.1 | 24.3 | GO:0019825 | oxygen binding(GO:0019825) |
| 1.1 | 16.7 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 2.4 | 14.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.0 | 13.5 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 2.2 | 13.4 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.1 | 12.5 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.1 | 12.0 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 3.8 | 11.4 | GO:0031177 | [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-acetyltransferase activity(GO:0016418) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) phosphopantetheine binding(GO:0031177) |
| 0.2 | 10.9 | GO:0005109 | frizzled binding(GO:0005109) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 11.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 10.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 9.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 5.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.2 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 24.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.5 | 19.7 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 1.5 | 16.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.2 | 14.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.8 | 13.9 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.3 | 13.4 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.2 | 10.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.5 | 9.2 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.4 | 6.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 6.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |