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GSE58827: Dynamics of the Mouse Liver
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Results for Nr1i3
Z-value: 2.57
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Transcription factors associated with Nr1i3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1i3 | mm39_v1_chr1_+_171041583_171041612 | 0.69 | 3.2e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1i3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 59.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 1.5 | 45.1 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 2.8 | 42.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 6.6 | 39.9 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
| 9.8 | 39.3 | GO:0010901 | regulation of very-low-density lipoprotein particle remodeling(GO:0010901) |
| 0.5 | 37.6 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 4.6 | 32.1 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 3.1 | 30.8 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 7.7 | 30.7 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 3.7 | 29.3 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 236.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 124.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 5.3 | 121.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.4 | 100.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 86.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 79.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 60.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 59.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.9 | 39.0 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 2.9 | 37.1 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 62.3 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 9.5 | 57.3 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.4 | 56.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 7.2 | 50.6 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 1.2 | 48.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 8.4 | 42.1 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 1.7 | 41.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 1.2 | 39.6 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 8.2 | 32.9 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.3 | 30.5 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 116.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 34.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 29.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.3 | 19.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 17.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 12.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 11.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 10.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 10.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 5.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 154.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 3.3 | 95.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 58.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.9 | 55.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.6 | 45.0 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 1.6 | 41.2 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 2.8 | 38.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.0 | 29.6 | REACTOME BILE ACID AND BILE SALT METABOLISM | Genes involved in Bile acid and bile salt metabolism |
| 2.0 | 28.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.3 | 23.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |