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GSE58827: Dynamics of the Mouse Liver
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Results for Nr2e1
Z-value: 3.42
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Transcription factors associated with Nr2e1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr2e1 | mm39_v1_chr10_-_42459624_42459635 | 0.00 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr2e1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 149.1 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 9.0 | 107.4 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 1.7 | 24.8 | GO:0015747 | urate transport(GO:0015747) |
| 1.5 | 13.8 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 1.3 | 13.8 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 9.1 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 8.3 | GO:0006839 | mitochondrial transport(GO:0006839) |
| 1.5 | 6.1 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.1 | 4.4 | GO:0072673 | lamellipodium morphogenesis(GO:0072673) |
| 0.1 | 4.4 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 226.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 43.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 25.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 24.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 18.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 13.8 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.3 | 6.1 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 4.8 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.3 | 4.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 4.4 | GO:0045177 | apical part of cell(GO:0045177) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 118.1 | GO:0005550 | pheromone binding(GO:0005550) |
| 35.8 | 107.4 | GO:0005009 | insulin-activated receptor activity(GO:0005009) |
| 0.8 | 35.5 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.7 | 27.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 2.5 | 24.8 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.1 | 19.8 | GO:0020037 | heme binding(GO:0020037) |
| 5.0 | 15.1 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 2.0 | 13.8 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.9 | 13.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 9.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 6.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 5.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 13.8 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.3 | 13.8 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.4 | 6.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.3 | 4.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 1.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.1 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |