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GSE58827: Dynamics of the Mouse Liver
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Results for Nrf1
Z-value: 3.58
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm39_v1_chr6_+_30047968_30048048 | 0.67 | 6.4e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 41.1 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 4.1 | 28.6 | GO:0045585 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.3 | 28.5 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.7 | 27.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 2.8 | 25.4 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 4.1 | 24.7 | GO:0070458 | detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458) |
| 2.1 | 20.9 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 2.5 | 20.1 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.7 | 18.9 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.8 | 17.8 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 85.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.6 | 85.0 | GO:0000776 | kinetochore(GO:0000776) |
| 1.2 | 30.6 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.4 | 29.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 4.7 | 28.2 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.1 | 24.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 23.0 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.3 | 22.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.3 | 19.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 19.2 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 114.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 42.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.5 | 36.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 4.0 | 28.2 | GO:0002135 | CTP binding(GO:0002135) |
| 0.2 | 26.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.9 | 25.1 | GO:0043295 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 2.7 | 24.4 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.7 | 24.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 22.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 21.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 59.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 36.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 29.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.1 | 27.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 23.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 18.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 17.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 16.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.8 | 13.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 12.8 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 51.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.7 | 48.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.5 | 44.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 38.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 1.4 | 31.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.6 | 29.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 1.2 | 27.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.4 | 24.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.8 | 23.5 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 1.2 | 21.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |