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GSE58827: Dynamics of the Mouse Liver
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Results for Obox6_Obox5
Z-value: 1.35
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Transcription factors associated with Obox6_Obox5
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_139708906 Show fit | 18.24 |
ENSMUST00000111986.8
ENSMUST00000027612.11 ENSMUST00000111989.9 |
complement factor H-related 4 |
|
| chr8_+_114860375 Show fit | 16.60 |
ENSMUST00000147605.8
ENSMUST00000134593.2 |
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr15_+_76579885 Show fit | 16.36 |
ENSMUST00000231028.2
|
glutamic pyruvic transaminase, soluble |
|
| chr15_+_76579960 Show fit | 16.26 |
ENSMUST00000229679.2
|
glutamic pyruvic transaminase, soluble |
|
| chr7_+_26534730 Show fit | 15.76 |
ENSMUST00000005685.15
|
cytochrome P450, family 2, subfamily a, polypeptide 5 |
|
| chr5_-_87572060 Show fit | 15.16 |
ENSMUST00000072818.6
|
UDP glucuronosyltransferase 2 family, polypeptide B38 |
|
| chr9_-_48516447 Show fit | 13.93 |
ENSMUST00000034808.12
ENSMUST00000119426.2 |
nicotinamide N-methyltransferase |
|
| chr8_+_114860342 Show fit | 13.28 |
ENSMUST00000109109.8
|
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr14_+_66205932 Show fit | 13.17 |
ENSMUST00000022616.14
|
clusterin |
|
| chr1_-_139487951 Show fit | 10.96 |
ENSMUST00000023965.8
|
complement factor H-related 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Obox6_Obox5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.3 | 41.1 | GO:0046356 | acetyl-CoA catabolic process(GO:0046356) |
| 0.8 | 26.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 1.2 | 20.8 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 1.8 | 16.2 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.3 | 14.5 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.9 | 14.2 | GO:0015747 | urate transport(GO:0015747) |
| 2.2 | 13.2 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.0 | 13.1 | GO:0032259 | methylation(GO:0032259) |
| 2.2 | 13.0 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.9 | 10.7 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 50.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 25.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 22.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 2.6 | 20.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 18.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 15.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.9 | 14.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.0 | 11.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.1 | 6.6 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 40.8 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.9 | 38.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 6.5 | 32.6 | GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 0.8 | 29.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 17.0 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.9 | 15.6 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 15.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 15.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.5 | 14.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 4.3 | 13.0 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 12.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 6.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 4.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 3.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 3.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 2.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 35.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.3 | 28.6 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.6 | 13.0 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 10.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 9.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 6.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 5.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 5.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.2 | 5.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.4 | 5.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |