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GSE58827: Dynamics of the Mouse Liver
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Results for Onecut1_Cux2
Z-value: 1.04
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Transcription factors associated with Onecut1_Cux2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Onecut1 | mm39_v1_chr9_+_74769166_74769203 | 0.55 | 4.7e-04 | Click! |
| Cux2 | mm39_v1_chr5_-_122187884_122187947 | -0.14 | 4.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_22769822 Show fit | 21.01 |
ENSMUST00000023590.9
|
histidine-rich glycoprotein |
|
| chr16_+_22769844 Show fit | 20.97 |
ENSMUST00000232422.2
|
histidine-rich glycoprotein |
|
| chr4_-_104733580 Show fit | 11.67 |
ENSMUST00000064873.9
ENSMUST00000106808.10 ENSMUST00000048947.15 |
complement component 8, alpha polypeptide |
|
| chr6_+_121323577 Show fit | 11.31 |
ENSMUST00000032200.16
|
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 |
|
| chr2_-_84605764 Show fit | 7.53 |
ENSMUST00000111641.2
|
serine (or cysteine) peptidase inhibitor, clade G, member 1 |
|
| chr2_-_84605732 Show fit | 7.53 |
ENSMUST00000023994.10
|
serine (or cysteine) peptidase inhibitor, clade G, member 1 |
|
| chr4_-_63072367 Show fit | 7.44 |
ENSMUST00000030041.5
|
alpha 1 microglobulin/bikunin precursor |
|
| chr15_-_60793115 Show fit | 7.42 |
ENSMUST00000096418.5
|
alpha-1-B glycoprotein |
|
| chr7_+_43856724 Show fit | 6.26 |
ENSMUST00000077354.5
|
kallikrein 1-related pepidase b4 |
|
| chr11_+_101258368 Show fit | 6.16 |
ENSMUST00000019469.3
|
glucose-6-phosphatase, catalytic |
Network of associatons between targets according to the STRING database.
First level regulatory network of Onecut1_Cux2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.0 | 42.0 | GO:0097037 | heme export(GO:0097037) |
| 5.0 | 15.1 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.7 | 11.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 2.3 | 11.3 | GO:0009992 | cellular water homeostasis(GO:0009992) |
| 0.5 | 7.4 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.2 | 6.3 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.6 | 6.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.7 | 6.0 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.3 | 5.9 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.4 | 5.7 | GO:0097421 | smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.0 | 42.0 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.1 | 33.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.3 | 11.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 9.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 8.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 6.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 6.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.8 | 5.7 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.7 | 3.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.0 | 3.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 1.2 | 32.7 | GO:0001848 | complement binding(GO:0001848) |
| 1.6 | 11.3 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 1.9 | 7.4 | GO:0019862 | IgA binding(GO:0019862) |
| 1.5 | 6.2 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.1 | 6.2 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.5 | 5.9 | GO:0016661 | oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) |
| 0.2 | 5.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 1.0 | 5.1 | GO:0055056 | dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 4.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 70.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 15.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.4 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 6.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 5.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 2.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 1.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 40.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.7 | 15.1 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 11.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.4 | 11.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 6.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.7 | 6.0 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 5.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 5.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 4.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |