ISMARA results: Pou1f1

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GSE58827: Dynamics of the Mouse Liver

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Results for Pou1f1

Z-value: 3.72

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Transcription factors associated with Pou1f1

Gene Symbol	Gene ID	Gene Info
Pou1f1 Ensembl NCBI MGI UniProt	ENSMUSG00000004842.19	POU domain, class 1, transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Pou1f1	mm39_v1_chr16_+_65317389_65317434	-0.15	3.7e-01	Click!

Activity profile of Pou1f1 motif

Sorted Z-values of Pou1f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_87074380 Show fit	72.86	ENSMUST00000031183.3	Ugt2b1 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide B1
chr5_-_87485023 Show fit	52.30	ENSMUST00000031195.3	Ugt2a3 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_60457902 Show fit	52.16	ENSMUST00000084548.11 ENSMUST00000103012.10 ENSMUST00000107499.4	Mup1 Ensembl NCBI MGI UniProt Show fit	major urinary protein 1
chr4_-_60777462 Show fit	51.95	ENSMUST00000211875.2	Mup22 Ensembl NCBI MGI UniProt Show fit	major urinary protein 22
chr4_-_60697274 Show fit	48.09	ENSMUST00000117932.2	Mup12 Ensembl NCBI MGI UniProt Show fit	major urinary protein 12
chr4_-_61259997 Show fit	47.31	ENSMUST00000071005.9 ENSMUST00000075206.12	Mup14 Ensembl NCBI MGI UniProt Show fit	major urinary protein 14
chr4_-_60222580 Show fit	46.32	ENSMUST00000095058.5 ENSMUST00000163931.8	Mup8 Ensembl NCBI MGI UniProt Show fit	major urinary protein 8
chr8_-_94006345 Show fit	36.95	ENSMUST00000034178.9	Ces1f Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1F
chr4_-_61437704 Show fit	36.61	ENSMUST00000095051.6 ENSMUST00000107483.8	Mup16 Ensembl NCBI MGI UniProt Show fit	major urinary protein 16
chr4_-_60538151 Show fit	35.29	ENSMUST00000098047.3	Mup10 Ensembl NCBI MGI UniProt Show fit	major urinary protein 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou1f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.7	187.6	GO:0019373	epoxygenase P450 pathway(GO:0019373)
5.9	82.9	GO:0052695	cellular glucuronidation(GO:0052695)
6.9	75.5	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
24.3	72.9	GO:0018879	biphenyl metabolic process(GO:0018879)
0.5	39.6	GO:0007566	embryo implantation(GO:0007566)
12.3	37.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
11.6	34.8	GO:0071395	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0	34.5	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
8.6	34.3	GO:0001970	positive regulation of activation of membrane attack complex(GO:0001970)
0.4	31.8	GO:0006749	glutathione metabolic process(GO:0006749)

Showing 1 to 10 of 363 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	333.6	GO:0005783	endoplasmic reticulum(GO:0005783)
5.8	52.1	GO:0005579	membrane attack complex(GO:0005579)
0.3	32.5	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3	32.2	GO:0005811	lipid particle(GO:0005811)
0.3	31.8	GO:0070469	respiratory chain(GO:0070469)
0.1	21.6	GO:0005802	trans-Golgi network(GO:0005802)
0.1	16.7	GO:0001650	fibrillar center(GO:0001650)
0.1	15.8	GO:0000800	lateral element(GO:0000800)
0.2	13.9	GO:0032420	stereocilium(GO:0032420)
0.5	13.6	GO:0034364	high-density lipoprotein particle(GO:0034364)

Showing 1 to 10 of 137 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	254.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
3.9	115.9	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.4	62.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
9.3	55.5	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
17.4	52.2	GO:0005009	insulin-activated receptor activity(GO:0005009)
1.0	50.3	GO:0004364	glutathione transferase activity(GO:0004364)
11.2	44.8	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.1	43.9	GO:0004984	olfactory receptor activity(GO:0004984)
11.6	34.8	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
10.6	31.7	GO:0005186	pheromone activity(GO:0005186)

Showing 1 to 10 of 258 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	11.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	10.8	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2	8.9	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	7.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	5.9	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1	5.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	4.8	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1	4.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	3.6	PID ENDOTHELIN PATHWAY	Endothelins

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	64.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.3	56.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.8	40.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
2.2	24.5	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.9	19.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
5.3	15.8	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.3	13.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.6	13.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
1.1	12.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.3	9.8	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation

Showing 1 to 10 of 80 entries

Results for Pou1f1

Z-value: 3.72

Motif logo

Transcription factors associated with Pou1f1

Activity-expression correlation:

Activity profile of Pou1f1 motif

Sorted Z-values of Pou1f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou1f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: