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GSE58827: Dynamics of the Mouse Liver
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Results for Ptf1a
Z-value: 2.12
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Transcription factors associated with Ptf1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ptf1a | mm39_v1_chr2_+_19450443_19450474 | 0.76 | 1.0e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_41291634 Show fit | 53.08 |
ENSMUST00000064324.12
|
trypsin 5 |
|
| chr8_-_112417633 Show fit | 43.83 |
ENSMUST00000034435.7
|
chymotrypsinogen B1 |
|
| chr6_+_41369290 Show fit | 33.13 |
ENSMUST00000049079.9
|
predicted gene 5771 |
|
| chr6_+_41435846 Show fit | 32.96 |
ENSMUST00000031910.8
|
protease, serine 1 (trypsin 1) |
|
| chr6_+_41279199 Show fit | 29.76 |
ENSMUST00000031913.5
|
trypsin 4 |
|
| chr7_+_28240262 Show fit | 26.76 |
ENSMUST00000119180.4
|
syncollin |
|
| chr6_+_41331039 Show fit | 24.89 |
ENSMUST00000072103.7
|
trypsin 10 |
|
| chr7_-_130924021 Show fit | 13.70 |
ENSMUST00000046611.9
|
CUB and zona pellucida-like domains 1 |
|
| chr2_+_164790139 Show fit | 8.78 |
ENSMUST00000017881.3
|
matrix metallopeptidase 9 |
|
| chr14_-_63654478 Show fit | 7.67 |
ENSMUST00000014597.5
|
B lymphoid kinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ptf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 213.0 | GO:0007586 | digestion(GO:0007586) |
| 0.0 | 22.2 | GO:0006887 | exocytosis(GO:0006887) |
| 0.1 | 13.3 | GO:0031638 | zymogen activation(GO:0031638) |
| 2.9 | 8.8 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.8 | 8.4 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 7.7 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 1.7 | 6.9 | GO:0061402 | glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
| 0.9 | 6.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 4.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.4 | 4.2 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 154.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 30.2 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.3 | 26.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 24.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 13.7 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 2.8 | 8.4 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.2 | 6.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 5.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 4.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 4.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 228.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 10.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.7 | 8.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 7.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 1.0 | 7.6 | GO:0005499 | vitamin D binding(GO:0005499) |
| 2.3 | 6.9 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.1 | 6.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 4.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 4.2 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 4.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 13.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 10.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 7.7 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 6.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.5 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 93.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 11.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.4 | 6.9 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.3 | 6.4 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 3.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.5 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 3.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.9 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.0 | 2.8 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |