ISMARA results: Sox2

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GSE58827: Dynamics of the Mouse Liver

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Results for Sox2

Z-value: 3.56

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Transcription factors associated with Sox2

Gene Symbol	Gene ID	Gene Info
Sox2 Ensembl NCBI MGI UniProt	ENSMUSG00000074637.8	SRY (sex determining region Y)-box 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Sox2	mm39_v1_chr3_+_34704554_34704554	0.17	3.2e-01	Click!

Activity profile of Sox2 motif

Sorted Z-values of Sox2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_43455157 Show fit	50.30	ENSMUST00000058714.10	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr10_+_43455919 Show fit	50.28	ENSMUST00000214476.2	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr5_-_134944366 Show fit	40.12	ENSMUST00000008987.5	Cldn13 Ensembl NCBI MGI UniProt Show fit	claudin 13
chr4_+_114914880 Show fit	31.82	ENSMUST00000161601.8	Tal1 Ensembl NCBI MGI UniProt Show fit	T cell acute lymphocytic leukemia 1
chr7_-_142215027 Show fit	30.22	ENSMUST00000105936.8	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr10_-_37014859 Show fit	29.65	ENSMUST00000092584.6	Marcks Ensembl NCBI MGI UniProt Show fit	myristoylated alanine rich protein kinase C substrate
chr3_+_14951264 Show fit	24.53	ENSMUST00000192609.6	Car2 Ensembl NCBI MGI UniProt Show fit	carbonic anhydrase 2
chr15_-_103159892 Show fit	24.52	ENSMUST00000133600.8 ENSMUST00000134554.2 ENSMUST00000156927.8	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr16_+_36097313 Show fit	23.47	ENSMUST00000232150.2	Stfa1 Ensembl NCBI MGI UniProt Show fit	stefin A1
chr7_-_126831803 Show fit	22.46	ENSMUST00000133913.8	Septin1 Ensembl NCBI MGI UniProt Show fit	septin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
33.5	100.6	GO:0034117	erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
3.1	61.4	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
4.0	60.7	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
1.9	46.9	GO:0021796	cerebral cortex regionalization(GO:0021796)
11.3	45.3	GO:0032849	positive regulation of cellular pH reduction(GO:0032849) dipeptide transmembrane transport(GO:0035442) regulation of oligopeptide transport(GO:0090088) regulation of dipeptide transport(GO:0090089) positive regulation of oligopeptide transport(GO:2000878) positive regulation of dipeptide transport(GO:2000880) regulation of dipeptide transmembrane transport(GO:2001148) positive regulation of dipeptide transmembrane transport(GO:2001150)
1.8	42.1	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
5.2	41.3	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
13.7	41.2	GO:0060217	hemangioblast cell differentiation(GO:0060217)
1.2	33.5	GO:0051764	actin crosslink formation(GO:0051764)
2.7	31.9	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)

Showing 1 to 10 of 451 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.7	100.6	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.3	58.1	GO:0032993	protein-DNA complex(GO:0032993)
0.4	51.3	GO:0005902	microvillus(GO:0005902)
4.4	48.3	GO:0097451	glial limiting end-foot(GO:0097451)
0.2	44.9	GO:0031965	nuclear membrane(GO:0031965)
7.2	43.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
13.7	41.2	GO:0033193	Lsd1/2 complex(GO:0033193)
1.9	39.8	GO:0031143	pseudopodium(GO:0031143)
0.5	38.7	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	32.1	GO:0005856	cytoskeleton(GO:0005856)

Showing 1 to 10 of 214 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.4	100.6	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.8	81.0	GO:0005518	collagen binding(GO:0005518)
0.0	66.1	GO:0003723	RNA binding(GO:0003723)
0.7	55.9	GO:0070888	E-box binding(GO:0070888)
4.5	45.3	GO:0004064	arylesterase activity(GO:0004064)
7.5	44.7	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
0.8	43.9	GO:0050699	WW domain binding(GO:0050699)
7.2	43.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	42.5	GO:0003779	actin binding(GO:0003779)
0.8	40.6	GO:0003785	actin monomer binding(GO:0003785)

Showing 1 to 10 of 296 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	98.7	PID E2F PATHWAY	E2F transcription factor network
1.1	63.2	PID AURORA B PATHWAY	Aurora B signaling
0.3	60.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.0	57.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.8	44.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	33.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.5	32.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	28.8	PID ATR PATHWAY	ATR signaling pathway
0.4	26.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.5	25.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	69.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.4	60.7	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
2.0	43.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.9	40.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.3	38.8	REACTOME AMYLOIDS	Genes involved in Amyloids
0.4	38.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	36.5	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.7	34.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.7	34.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	34.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling

Showing 1 to 10 of 103 entries

Results for Sox2

Z-value: 3.56

Motif logo

Transcription factors associated with Sox2

Activity-expression correlation:

Activity profile of Sox2 motif

Sorted Z-values of Sox2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: