ISMARA results: Spib

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GSE58827: Dynamics of the Mouse Liver

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Results for Spib

Z-value: 4.04

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Transcription factors associated with Spib

Gene Symbol	Gene ID	Gene Info
Spib Ensembl NCBI MGI UniProt	ENSMUSG00000008193.14	Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Spib	mm39_v1_chr7_-_44181477_44181502	0.87	5.8e-12	Click!

Activity profile of Spib motif

Sorted Z-values of Spib motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_136918671 Show fit	41.29	ENSMUST00000032344.12	Arhgdib Ensembl NCBI MGI UniProt Show fit	Rho, GDP dissociation inhibitor (GDI) beta
chr14_+_80237691 Show fit	34.37	ENSMUST00000228749.2 ENSMUST00000088735.4	Olfm4 Ensembl NCBI MGI UniProt Show fit	olfactomedin 4
chr5_+_149201577 Show fit	27.78	ENSMUST00000071130.5	Alox5ap Ensembl NCBI MGI UniProt Show fit	arachidonate 5-lipoxygenase activating protein
chr11_-_103235475 Show fit	23.58	ENSMUST00000041385.14	Arhgap27 Ensembl NCBI MGI UniProt Show fit	Rho GTPase activating protein 27
chr11_-_16958647 Show fit	23.27	ENSMUST00000102881.10	Plek Ensembl NCBI MGI UniProt Show fit	pleckstrin
chr5_+_149202157 Show fit	23.20	ENSMUST00000200806.4	Alox5ap Ensembl NCBI MGI UniProt Show fit	arachidonate 5-lipoxygenase activating protein
chr5_-_134258435 Show fit	23.06	ENSMUST00000016094.13 ENSMUST00000111275.8 ENSMUST00000144086.2	Ncf1 Ensembl NCBI MGI UniProt Show fit	neutrophil cytosolic factor 1
chr9_+_55997246 Show fit	22.82	ENSMUST00000059206.8	Pstpip1 Ensembl NCBI MGI UniProt Show fit	proline-serine-threonine phosphatase-interacting protein 1
chr15_-_66684442 Show fit	22.80	ENSMUST00000100572.10	Sla Ensembl NCBI MGI UniProt Show fit	src-like adaptor
chr7_+_99184645 Show fit	20.94	ENSMUST00000098266.9 ENSMUST00000179755.8	Arrb1 Ensembl NCBI MGI UniProt Show fit	arrestin, beta 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Spib

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	72.2	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
6.8	61.0	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
1.8	55.9	GO:0032060	bleb assembly(GO:0032060)
6.9	55.1	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
8.5	51.0	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
4.3	47.3	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6	36.2	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
5.6	33.5	GO:0070560	calcium-mediated signaling using extracellular calcium source(GO:0035585) protein secretion by platelet(GO:0070560)
2.0	31.3	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3	27.7	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	109.3	GO:0016021	integral component of membrane(GO:0016021)
2.1	53.4	GO:0032426	stereocilium tip(GO:0032426)
0.8	50.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.4	44.7	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.1	43.6	GO:0031965	nuclear membrane(GO:0031965)
0.9	42.6	GO:0001772	immunological synapse(GO:0001772)
0.2	36.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	34.8	GO:0032587	ruffle membrane(GO:0032587)
1.4	34.4	GO:0042581	specific granule(GO:0042581)
4.8	33.5	GO:0031095	platelet dense tubular network membrane(GO:0031095)

Showing 1 to 10 of 87 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	73.5	GO:0004896	cytokine receptor activity(GO:0004896)
6.8	61.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.9	57.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
2.5	53.4	GO:0032036	myosin heavy chain binding(GO:0032036)
10.2	51.0	GO:0004051	arachidonate 5-lipoxygenase activity(GO:0004051)
0.2	45.9	GO:0017124	SH3 domain binding(GO:0017124)
0.7	43.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
1.0	37.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.0	36.7	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.4	33.5	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 117 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	67.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
1.1	61.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.8	58.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.6	57.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
1.5	52.5	PID IL5 PATHWAY	IL5-mediated signaling events
0.5	40.3	PID RAC1 PATHWAY	RAC1 signaling pathway
0.6	23.2	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	22.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	19.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	17.0	PID IL4 2PATHWAY	IL4-mediated signaling events

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	89.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.9	70.6	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.7	57.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
1.1	56.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
1.8	34.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.4	32.0	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
1.4	29.8	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.7	25.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
1.4	22.8	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	22.0	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall

Showing 1 to 10 of 61 entries

Results for Spib

Z-value: 4.04

Motif logo

Transcription factors associated with Spib

Activity-expression correlation:

Activity profile of Spib motif

Sorted Z-values of Spib motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spib

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: