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GSE58827: Dynamics of the Mouse Liver
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Results for Spic
Z-value: 4.44
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Transcription factors associated with Spic
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spic | mm39_v1_chr10_-_88518878_88518892 | 0.96 | 2.7e-20 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_87684299 Show fit | 52.25 |
ENSMUST00000020779.11
|
myeloperoxidase |
|
| chr10_+_79715448 Show fit | 50.13 |
ENSMUST00000006679.15
|
proteinase 3 |
|
| chr2_-_165242307 Show fit | 44.90 |
ENSMUST00000029213.5
|
osteoclast stimulatory transmembrane protein |
|
| chr11_+_87684548 Show fit | 38.63 |
ENSMUST00000143021.9
|
myeloperoxidase |
|
| chr14_+_80237691 Show fit | 35.89 |
ENSMUST00000228749.2
ENSMUST00000088735.4 |
olfactomedin 4 |
|
| chr6_-_136918671 Show fit | 32.21 |
ENSMUST00000032344.12
|
Rho, GDP dissociation inhibitor (GDI) beta |
|
| chr6_-_136918844 Show fit | 30.36 |
ENSMUST00000204934.2
|
Rho, GDP dissociation inhibitor (GDI) beta |
|
| chr7_-_126303351 Show fit | 27.54 |
ENSMUST00000106364.8
|
coronin, actin binding protein 1A |
|
| chr7_-_126303887 Show fit | 26.86 |
ENSMUST00000131415.8
|
coronin, actin binding protein 1A |
|
| chr11_+_98798627 Show fit | 25.76 |
ENSMUST00000092706.13
|
cell division cycle 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spic
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 101.1 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 30.3 | 90.9 | GO:0002148 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 9.2 | 74.0 | GO:0061502 | uropod organization(GO:0032796) early endosome to recycling endosome transport(GO:0061502) |
| 5.6 | 66.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 10.0 | 50.1 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
| 8.2 | 49.0 | GO:0002540 | leukotriene production involved in inflammatory response(GO:0002540) |
| 4.4 | 47.9 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 11.2 | 44.9 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 2.3 | 42.2 | GO:0015816 | glycine transport(GO:0015816) |
| 1.2 | 42.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 127.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 99.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 5.3 | 90.9 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 4.7 | 74.9 | GO:0042555 | MCM complex(GO:0042555) |
| 3.0 | 74.0 | GO:0032426 | stereocilium tip(GO:0032426) |
| 1.0 | 56.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 49.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 43.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 38.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.1 | 37.3 | GO:0042581 | specific granule(GO:0042581) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 101.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 6.8 | 87.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 1.1 | 76.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 3.5 | 74.0 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.3 | 72.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 68.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.3 | 57.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 9.8 | 49.0 | GO:0004051 | arachidonate 5-lipoxygenase activity(GO:0004051) |
| 3.0 | 42.2 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 41.4 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 122.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 2.0 | 110.7 | PID ATR PATHWAY | ATR signaling pathway |
| 1.1 | 90.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.4 | 85.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.4 | 58.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.1 | 52.8 | PID EPO PATHWAY | EPO signaling pathway |
| 0.2 | 45.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 34.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.7 | 25.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 25.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 155.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.0 | 98.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 4.7 | 74.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.6 | 42.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 40.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 1.0 | 33.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.4 | 29.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 26.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.7 | 25.8 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.3 | 25.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |