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GSE58827: Dynamics of the Mouse Liver
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Results for Taf1
Z-value: 4.14
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Transcription factors associated with Taf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Taf1 | mm39_v1_chrX_+_100576340_100576383 | 0.92 | 7.6e-16 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Taf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 69.5 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.4 | 43.0 | GO:0006413 | translational initiation(GO:0006413) |
| 2.1 | 39.6 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.5 | 34.8 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.5 | 31.7 | GO:0016441 | posttranscriptional gene silencing(GO:0016441) |
| 0.4 | 27.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 2.4 | 26.9 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.6 | 23.9 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 3.9 | 23.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.5 | 22.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 128.9 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.2 | 95.7 | GO:0016604 | nuclear body(GO:0016604) |
| 0.6 | 46.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 41.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 37.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 37.5 | GO:0005694 | chromosome(GO:0005694) |
| 0.6 | 37.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 33.8 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.8 | 31.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.3 | 28.6 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 198.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 71.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.9 | 60.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.7 | 48.9 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.2 | 46.6 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 44.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 32.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.4 | 23.8 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 3.4 | 23.5 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.2 | 21.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 59.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 38.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 34.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.5 | 33.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.2 | 24.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 18.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 17.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 16.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 16.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.3 | 15.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 75.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.2 | 62.0 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.5 | 55.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.5 | 40.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 1.1 | 35.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 32.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 27.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 26.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.4 | 24.6 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.1 | 23.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |