ISMARA results: Tbp

Project

GSE58827: Dynamics of the Mouse Liver

Navigation

Downloads

Results for Tbp

Z-value: 3.50

Motif logo

Transcription factors associated with Tbp

Gene Symbol	Gene ID	Gene Info
Tbp Ensembl NCBI MGI UniProt	ENSMUSG00000014767.18	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbp	mm39_v1_chr17_+_15720150_15720222	0.53	9.3e-04	Click!

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_90603013 Show fit	42.90	ENSMUST00000069960.12 ENSMUST00000117167.2	S100a9 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A9 (calgranulin B)
chr11_+_87684299 Show fit	33.63	ENSMUST00000020779.11	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr5_+_90920294 Show fit	29.10	ENSMUST00000031320.8	Pf4 Ensembl NCBI MGI UniProt Show fit	platelet factor 4
chr5_+_90920353 Show fit	27.87	ENSMUST00000202625.2	Pf4 Ensembl NCBI MGI UniProt Show fit	platelet factor 4
chr9_+_98372575 Show fit	27.82	ENSMUST00000035029.3	Rbp2 Ensembl NCBI MGI UniProt Show fit	retinol binding protein 2, cellular
chr4_+_120523758 Show fit	25.96	ENSMUST00000094814.6	Cited4 Ensembl NCBI MGI UniProt Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr7_-_103463120 Show fit	25.60	ENSMUST00000098192.4	Hbb-bt Ensembl NCBI MGI UniProt Show fit	hemoglobin, beta adult t chain
chr6_-_41291634 Show fit	23.71	ENSMUST00000064324.12	Try5 Ensembl NCBI MGI UniProt Show fit	trypsin 5
chr17_-_31348576 Show fit	23.42	ENSMUST00000024827.5	Tff3 Ensembl NCBI MGI UniProt Show fit	trefoil factor 3, intestinal
chr7_-_103477126 Show fit	22.12	ENSMUST00000023934.8	Hbb-bs Ensembl NCBI MGI UniProt Show fit	hemoglobin, beta adult s chain

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	76.4	GO:0007586	digestion(GO:0007586)
12.4	62.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
5.0	59.7	GO:0002536	respiratory burst involved in inflammatory response(GO:0002536)
2.0	49.9	GO:0000028	ribosomal small subunit assembly(GO:0000028)
14.5	43.4	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
7.5	37.3	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
11.2	33.6	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
1.3	29.0	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
3.1	27.8	GO:0006776	vitamin A metabolic process(GO:0006776)
0.8	26.9	GO:0019731	antibacterial humoral response(GO:0019731)

Showing 1 to 10 of 155 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	71.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	65.2	GO:0031012	extracellular matrix(GO:0031012)
4.1	57.0	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.2	52.2	GO:0043209	myelin sheath(GO:0043209)
8.3	41.7	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
1.2	39.9	GO:0005680	anaphase-promoting complex(GO:0005680)
2.0	33.6	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	30.9	GO:0005730	nucleolus(GO:0005730)
0.3	24.5	GO:0005871	kinesin complex(GO:0005871)
0.1	24.3	GO:0000793	condensed chromosome(GO:0000793)

Showing 1 to 10 of 82 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	126.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
4.0	59.7	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
14.8	59.1	GO:0031721	hemoglobin alpha binding(GO:0031721)
9.5	57.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.3	48.7	GO:0003735	structural constituent of ribosome(GO:0003735)
5.4	42.9	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
3.3	39.2	GO:0008061	chitin binding(GO:0008061)
0.7	38.3	GO:0004601	peroxidase activity(GO:0004601)
0.7	37.3	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.7	34.3	GO:0003785	actin monomer binding(GO:0003785)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	82.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	57.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.9	50.1	PID AURORA B PATHWAY	Aurora B signaling
0.4	44.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.6	33.6	PID IL23 PATHWAY	IL23-mediated signaling events
0.3	33.0	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.5	17.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	17.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.5	17.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.3	15.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	71.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
3.4	57.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	41.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.3	39.9	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	35.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.6	26.9	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.8	24.5	REACTOME KINESINS	Genes involved in Kinesins
0.6	21.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.3	20.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	17.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 46 entries

Results for Tbp

Z-value: 3.50

Motif logo

Transcription factors associated with Tbp

Activity-expression correlation:

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: