ISMARA results: Yy1

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GSE58827: Dynamics of the Mouse Liver

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Results for Yy1_Yy2

Z-value: 3.31

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Transcription factors associated with Yy1_Yy2

Gene Symbol	Gene ID	Gene Info
Yy1 Ensembl NCBI MGI UniProt	ENSMUSG00000021264.13	YY1 transcription factor
Yy2 Ensembl NCBI MGI UniProt	ENSMUSG00000091736.4	Yy2 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Yy2	mm39_v1_chrX_-_156351979_156351987	0.27	1.2e-01	Click!
Yy1	mm39_v1_chr12_+_108758871_108758914	-0.02	9.0e-01	Click!

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_90603013 Show fit	23.81	ENSMUST00000069960.12 ENSMUST00000117167.2	S100a9 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A9 (calgranulin B)
chr14_-_69522431 Show fit	22.91	ENSMUST00000183882.2 ENSMUST00000037064.5	Slc25a37 Ensembl NCBI MGI UniProt Show fit	solute carrier family 25, member 37
chr8_-_122634418 Show fit	20.72	ENSMUST00000045557.10	Slc7a5 Ensembl NCBI MGI UniProt Show fit	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
chr5_-_134944366 Show fit	20.44	ENSMUST00000008987.5	Cldn13 Ensembl NCBI MGI UniProt Show fit	claudin 13
chr1_-_132294807 Show fit	18.09	ENSMUST00000136828.3	Tmcc2 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 2
chr11_-_102360664 Show fit	16.50	ENSMUST00000103086.4	Itga2b Ensembl NCBI MGI UniProt Show fit	integrin alpha 2b
chr11_+_117740077 Show fit	16.31	ENSMUST00000081387.11	Birc5 Ensembl NCBI MGI UniProt Show fit	baculoviral IAP repeat-containing 5
chr3_+_90576285 Show fit	16.31	ENSMUST00000069927.10	S100a8 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A8 (calgranulin A)
chr7_-_103463120 Show fit	13.35	ENSMUST00000098192.4	Hbb-bt Ensembl NCBI MGI UniProt Show fit	hemoglobin, beta adult t chain
chr13_-_97897139 Show fit	11.94	ENSMUST00000074072.5	Rps18-ps6 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S18, pseudogene 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	99.3	GO:0002181	cytoplasmic translation(GO:0002181)
0.4	57.3	GO:0006364	rRNA processing(GO:0006364)
1.3	41.1	GO:0000027	ribosomal large subunit assembly(GO:0000027)
5.8	40.4	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
1.4	40.3	GO:0000028	ribosomal small subunit assembly(GO:0000028)
8.5	33.9	GO:0070488	neutrophil aggregation(GO:0070488)
0.4	33.8	GO:0070527	platelet aggregation(GO:0070527)
0.2	30.8	GO:0050853	B cell receptor signaling pathway(GO:0050853)
1.5	27.2	GO:0015816	glycine transport(GO:0015816)
0.6	24.2	GO:0048821	erythrocyte development(GO:0048821)

Showing 1 to 10 of 887 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	196.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
2.0	111.8	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
6.8	40.8	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	37.2	GO:0005730	nucleolus(GO:0005730)
0.4	32.3	GO:0005871	kinesin complex(GO:0005871)
0.2	31.7	GO:0000775	chromosome, centromeric region(GO:0000775)
6.3	31.6	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.6	30.8	GO:0015030	Cajal body(GO:0015030)
0.4	29.5	GO:0015934	large ribosomal subunit(GO:0015934)
0.4	27.2	GO:0005643	nuclear pore(GO:0005643)

Showing 1 to 10 of 376 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	267.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.5	72.4	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.9	44.3	GO:0008536	Ran GTPase binding(GO:0008536)
5.0	40.3	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
1.9	34.7	GO:0003688	DNA replication origin binding(GO:0003688)
0.2	33.9	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.3	33.7	GO:0003777	microtubule motor activity(GO:0003777)
8.1	32.6	GO:0031720	haptoglobin binding(GO:0031720)
0.2	28.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.0	27.6	GO:0015187	glycine transmembrane transporter activity(GO:0015187)

Showing 1 to 10 of 549 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	68.4	PID AURORA A PATHWAY	Aurora A signaling
0.4	40.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.7	39.9	PID ATR PATHWAY	ATR signaling pathway
0.8	37.4	PID AURORA B PATHWAY	Aurora B signaling
0.7	34.1	PID PLK1 PATHWAY	PLK1 signaling events
0.9	34.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.7	32.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.4	28.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.5	25.8	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4	23.0	PID P53 REGULATION PATHWAY	p53 pathway

Showing 1 to 10 of 119 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	328.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.8	62.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.8	50.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.1	41.8	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4	38.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.7	33.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
2.0	32.5	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.7	32.0	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.9	29.4	REACTOME KINESINS	Genes involved in Kinesins
0.3	29.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 172 entries

Results for Yy1_Yy2

Z-value: 3.31

Motif logo

Transcription factors associated with Yy1_Yy2

Activity-expression correlation:

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: