ISMARA results: Zfx

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GSE58827: Dynamics of the Mouse Liver

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Results for Zfx_Zfp711

Z-value: 3.16

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Transcription factors associated with Zfx_Zfp711

Gene Symbol	Gene ID	Gene Info
Zfx Ensembl NCBI MGI UniProt	ENSMUSG00000079509.11	zinc finger protein X-linked
Zfp711 Ensembl NCBI MGI UniProt	ENSMUSG00000025529.15	zinc finger protein 711

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zfx	mm39_v1_chrX_-_93166992_93167018	0.90	3.7e-14	Click!
Zfp711	mm39_v1_chrX_+_111510223_111510223	0.62	5.3e-05	Click!

Activity profile of Zfx_Zfp711 motif

Sorted Z-values of Zfx_Zfp711 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_74510413 Show fit	12.05	ENSMUST00000100866.3	Ccdc92b Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 92B
chr4_+_156046745 Show fit	10.64	ENSMUST00000024338.5	C1qtnf12 Ensembl NCBI MGI UniProt Show fit	C1q and tumor necrosis factor related 12
chr7_-_37806912 Show fit	10.35	ENSMUST00000108023.10	Ccne1 Ensembl NCBI MGI UniProt Show fit	cyclin E1
chr14_-_70873385 Show fit	9.74	ENSMUST00000228295.2 ENSMUST00000022695.16	Dmtn Ensembl NCBI MGI UniProt Show fit	dematin actin binding protein
chr7_-_142211203 Show fit	9.17	ENSMUST00000097936.9 ENSMUST00000000033.12	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr9_+_110848339 Show fit	8.85	ENSMUST00000198884.5 ENSMUST00000196777.5 ENSMUST00000196209.5 ENSMUST00000035077.8 ENSMUST00000196122.3	Ltf Ensembl NCBI MGI UniProt Show fit	lactotransferrin
chrX_+_72683020 Show fit	8.59	ENSMUST00000019701.9	Dusp9 Ensembl NCBI MGI UniProt Show fit	dual specificity phosphatase 9
chr10_+_79722081 Show fit	7.74	ENSMUST00000046091.7	Elane Ensembl NCBI MGI UniProt Show fit	elastase, neutrophil expressed
chr15_+_89218601 Show fit	7.20	ENSMUST00000023282.9	Miox Ensembl NCBI MGI UniProt Show fit	myo-inositol oxygenase
chr15_+_73596602 Show fit	7.14	ENSMUST00000230177.2 ENSMUST00000163582.9	Ptp4a3 Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase 4a3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfx_Zfp711

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	64.6	GO:0008380	RNA splicing(GO:0008380)
0.4	29.2	GO:0051225	spindle assembly(GO:0051225)
0.8	29.1	GO:0006270	DNA replication initiation(GO:0006270)
4.0	24.2	GO:0035585	calcium-mediated signaling using extracellular calcium source(GO:0035585)
1.9	22.4	GO:0002536	respiratory burst involved in inflammatory response(GO:0002536)
0.5	18.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
1.5	17.9	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
3.5	17.7	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.5	17.2	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3	15.7	GO:0045773	positive regulation of axon extension(GO:0045773)

Showing 1 to 10 of 1,058 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	60.1	GO:0016607	nuclear speck(GO:0016607)
0.6	45.9	GO:0005643	nuclear pore(GO:0005643)
0.5	36.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	36.2	GO:0005694	chromosome(GO:0005694)
0.3	34.9	GO:0017053	transcriptional repressor complex(GO:0017053)
0.3	30.2	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.2	25.5	GO:0005902	microvillus(GO:0005902)
0.2	25.1	GO:0000776	kinetochore(GO:0000776)
3.5	24.7	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.1	24.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Showing 1 to 10 of 407 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	223.3	GO:0003723	RNA binding(GO:0003723)
0.2	76.1	GO:0045296	cadherin binding(GO:0045296)
0.5	41.5	GO:0030507	spectrin binding(GO:0030507)
0.3	37.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.9	34.6	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.1	33.9	GO:0005096	GTPase activator activity(GO:0005096)
0.7	31.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.4	23.2	GO:0003743	translation initiation factor activity(GO:0003743)
0.6	21.3	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4	20.4	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)

Showing 1 to 10 of 608 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	45.3	PID AURORA B PATHWAY	Aurora B signaling
0.5	31.0	PID PLK1 PATHWAY	PLK1 signaling events
0.4	27.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.4	27.3	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.5	23.6	PID ATR PATHWAY	ATR signaling pathway
0.2	23.1	PID CMYB PATHWAY	C-MYB transcription factor network
0.5	22.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	20.6	PID RAC1 PATHWAY	RAC1 signaling pathway
0.3	18.8	PID P53 REGULATION PATHWAY	p53 pathway
0.9	18.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Showing 1 to 10 of 132 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	65.6	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.4	52.3	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.5	48.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.1	34.7	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.5	33.6	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.5	29.6	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5	27.0	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	27.0	REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	Genes involved in Class I MHC mediated antigen processing & presentation
0.6	26.3	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
1.7	22.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation

Showing 1 to 10 of 175 entries

Results for Zfx_Zfp711

Z-value: 3.16

Motif logo

Transcription factors associated with Zfx_Zfp711

Activity-expression correlation:

Activity profile of Zfx_Zfp711 motif

Sorted Z-values of Zfx_Zfp711 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfx_Zfp711

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: