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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for AAGGUGC

Z-value: 0.42

Motif logo

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miRNA associated with seed AAGGUGC

NamemiRBASE accession
hsa-miR-18a-5p
MIMAT0000072
hsa-miR-18b-5p
MIMAT0001412
hsa-miR-4735-3p
MIMAT0019861

Activity profile of AAGGUGC motif

Sorted Z-values of AAGGUGC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_185956348 1.51 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
SORBS2
sorbin and SH3 domain containing 2
chr2_+_12716893 1.06 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr6_-_16761447 1.04 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr20_+_36092698 1.03 ENST00000430276.5
ENST00000373950.6
ENST00000373946.7
ENST00000441639.5
ENST00000628415.2
ENST00000452261.5
EPB41L1
erythrocyte membrane protein band 4.1 like 1
chr6_+_11537738 0.81 ENST00000379426.2
TMEM170B
transmembrane protein 170B
chr4_+_54657918 0.80 ENST00000412167.6
ENST00000288135.6
KIT
KIT proto-oncogene, receptor tyrosine kinase
chr3_+_37861926 0.69 ENST00000443503.6
CTDSPL
CTD small phosphatase like
chr6_-_110815408 0.67 ENST00000368911.8
CDK19
cyclin dependent kinase 19
chr8_-_80874771 0.52 ENST00000327835.7
ZNF704
zinc finger protein 704
chr2_+_28392802 0.49 ENST00000379619.5
ENST00000264716.9
FOSL2
FOS like 2, AP-1 transcription factor subunit
chr5_+_56815534 0.44 ENST00000399503.4
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr10_-_79445617 0.43 ENST00000372336.4
ZCCHC24
zinc finger CCHC-type containing 24
chr1_-_94541746 0.43 ENST00000334047.12
F3
coagulation factor III, tissue factor
chr17_+_70169516 0.39 ENST00000243457.4
KCNJ2
potassium inwardly rectifying channel subfamily J member 2
chr11_+_108223112 0.39 ENST00000452508.6
ENST00000683914.1
ENST00000683150.1
ENST00000639953.1
ENST00000640388.1
ENST00000639240.1
ATM
ATM serine/threonine kinase
chr15_+_39581068 0.37 ENST00000397591.2
ENST00000260356.6
THBS1
thrombospondin 1
chr11_-_117098415 0.35 ENST00000445177.6
ENST00000375300.6
ENST00000446921.6
SIK3
SIK family kinase 3
chr5_+_79236092 0.35 ENST00000396137.5
JMY
junction mediating and regulatory protein, p53 cofactor
chr1_-_162023826 0.34 ENST00000294794.8
OLFML2B
olfactomedin like 2B
chr1_+_173714908 0.33 ENST00000209884.5
KLHL20
kelch like family member 20
chr3_+_107522936 0.31 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX
BBX high mobility group box domain containing
chr6_+_137867414 0.31 ENST00000237289.8
ENST00000433680.1
TNFAIP3
TNF alpha induced protein 3
chr12_-_56189548 0.28 ENST00000347471.8
ENST00000267064.8
ENST00000394023.7
SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
chr11_-_130314686 0.27 ENST00000525842.5
ZBTB44
zinc finger and BTB domain containing 44
chr4_-_42657085 0.26 ENST00000264449.14
ENST00000510289.1
ENST00000381668.9
ATP8A1
ATPase phospholipid transporting 8A1
chr1_-_20486197 0.26 ENST00000375078.4
CAMK2N1
calcium/calmodulin dependent protein kinase II inhibitor 1
chr2_+_234952009 0.23 ENST00000392011.7
SH3BP4
SH3 domain binding protein 4
chr11_+_95089804 0.23 ENST00000278505.5
ENDOD1
endonuclease domain containing 1
chr3_+_43286512 0.23 ENST00000454177.5
ENST00000429705.6
ENST00000296088.12
ENST00000437827.1
SNRK
SNF related kinase
chr15_-_34336749 0.20 ENST00000397707.6
ENST00000560611.5
SLC12A6
solute carrier family 12 member 6
chr3_-_115071333 0.20 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_136050502 0.20 ENST00000371753.5
NACC2
NACC family member 2
chr18_+_22933819 0.20 ENST00000399722.6
ENST00000399725.6
ENST00000399721.6
RBBP8
RB binding protein 8, endonuclease
chr17_-_42154916 0.19 ENST00000592574.1
ENST00000550406.1
ENST00000547517.5
ENST00000346213.9
ENST00000393860.7
ENSG00000267261.5
RAB5C
novel protein
RAB5C, member RAS oncogene family
chr6_+_16238554 0.19 ENST00000259727.5
GMPR
guanosine monophosphate reductase
chrX_-_24027186 0.19 ENST00000328046.8
KLHL15
kelch like family member 15
chr5_-_74640719 0.18 ENST00000302351.9
ENST00000509127.2
ENC1
ectodermal-neural cortex 1
chr15_-_61229297 0.18 ENST00000335670.11
RORA
RAR related orphan receptor A
chr9_+_122941003 0.18 ENST00000373647.9
ENST00000402311.5
RABGAP1
RAB GTPase activating protein 1
chr2_-_55419565 0.17 ENST00000647341.1
ENST00000647401.1
ENST00000336838.10
ENST00000621814.4
ENST00000644033.1
ENST00000645477.1
ENST00000647517.1
CCDC88A
coiled-coil domain containing 88A
chr6_-_131951364 0.17 ENST00000367976.4
CCN2
cellular communication network factor 2
chr1_+_84078043 0.15 ENST00000370689.6
ENST00000370688.7
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr1_-_202808406 0.15 ENST00000650569.1
ENST00000367265.9
ENST00000649770.1
KDM5B
lysine demethylase 5B
chr12_+_4909895 0.14 ENST00000638821.1
ENST00000382545.5
ENSG00000256654.4
KCNA1
novel transcript, sense overlapping KCNA1
potassium voltage-gated channel subfamily A member 1
chr12_+_109097568 0.14 ENST00000242576.7
UNG
uracil DNA glycosylase
chr6_-_107115493 0.14 ENST00000369042.6
BEND3
BEN domain containing 3
chr9_-_71768386 0.14 ENST00000377066.9
ENST00000377044.9
CEMIP2
cell migration inducing hyaluronidase 2
chr16_+_30949054 0.13 ENST00000318663.5
ENST00000566237.1
ENST00000562699.1
ORAI3
ORAI calcium release-activated calcium modulator 3
chr6_+_39792993 0.13 ENST00000538976.5
DAAM2
dishevelled associated activator of morphogenesis 2
chr5_+_123089223 0.13 ENST00000407847.5
PRDM6
PR/SET domain 6
chr12_+_55966821 0.13 ENST00000553376.5
ENST00000440311.6
ENST00000266970.9
ENST00000354056.4
CDK2
cyclin dependent kinase 2
chr4_-_124712721 0.13 ENST00000504087.6
ENST00000515641.1
ANKRD50
ankyrin repeat domain 50
chr16_-_17470953 0.12 ENST00000261381.7
XYLT1
xylosyltransferase 1
chr17_-_7479616 0.12 ENST00000380599.9
ZBTB4
zinc finger and BTB domain containing 4
chr12_+_19439469 0.12 ENST00000266508.14
AEBP2
AE binding protein 2
chr3_-_185825029 0.11 ENST00000382199.7
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chr14_+_102592611 0.11 ENST00000262241.7
RCOR1
REST corepressor 1
chr19_+_1753499 0.11 ENST00000382349.5
ONECUT3
one cut homeobox 3
chr1_-_50960230 0.10 ENST00000396153.7
FAF1
Fas associated factor 1
chr19_+_3572927 0.10 ENST00000333651.11
ENST00000417382.5
HMG20B
high mobility group 20B
chr1_-_227947924 0.10 ENST00000272164.6
WNT9A
Wnt family member 9A
chr9_+_93576557 0.10 ENST00000359246.9
ENST00000375376.8
PHF2
PHD finger protein 2
chr16_-_57186014 0.09 ENST00000566584.5
ENST00000566481.5
ENST00000566077.5
ENST00000564108.5
ENST00000309137.13
ENST00000565458.5
ENST00000566681.1
ENST00000567439.5
PSME3IP1
proteasome activator subunit 3 interacting protein 1
chr19_+_13118235 0.09 ENST00000292431.5
NACC1
nucleus accumbens associated 1
chrX_+_151397163 0.09 ENST00000330374.7
VMA21
vacuolar ATPase assembly factor VMA21
chr9_-_90642791 0.09 ENST00000375765.5
ENST00000636786.1
DIRAS2
DIRAS family GTPase 2
chr3_+_152299392 0.09 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
MBNL1
muscleblind like splicing regulator 1
chr19_-_36032799 0.09 ENST00000592017.5
ENST00000360535.9
CLIP3
CAP-Gly domain containing linker protein 3
chr4_+_182243394 0.09 ENST00000511685.6
TENM3
teneurin transmembrane protein 3
chr22_+_40177917 0.09 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr9_-_96418334 0.09 ENST00000375256.5
ZNF367
zinc finger protein 367
chrX_-_19887585 0.08 ENST00000397821.8
SH3KBP1
SH3 domain containing kinase binding protein 1
chr8_+_141391989 0.08 ENST00000520105.5
ENST00000523147.5
ENST00000521578.6
PTP4A3
protein tyrosine phosphatase 4A3
chr9_-_35563867 0.08 ENST00000399742.7
ENST00000619051.4
FAM166B
family with sequence similarity 166 member B
chr8_+_64580357 0.07 ENST00000321870.3
BHLHE22
basic helix-loop-helix family member e22
chr5_+_108747879 0.07 ENST00000281092.9
FER
FER tyrosine kinase
chr6_+_122399536 0.07 ENST00000452194.5
HSF2
heat shock transcription factor 2
chr8_+_28890365 0.06 ENST00000519662.5
ENST00000558662.5
ENST00000287701.15
ENST00000523613.5
ENST00000560599.5
ENST00000397358.7
HMBOX1
homeobox containing 1
chr6_-_99425269 0.06 ENST00000647811.1
ENST00000481229.2
ENST00000369239.10
ENST00000681611.1
ENST00000681615.1
ENST00000438806.5
PNISR
PNN interacting serine and arginine rich protein
chr5_-_172283743 0.06 ENST00000393792.3
UBTD2
ubiquitin domain containing 2
chr2_-_200963633 0.05 ENST00000234296.7
ORC2
origin recognition complex subunit 2
chr16_-_85688912 0.05 ENST00000253462.8
GINS2
GINS complex subunit 2
chr1_+_32108035 0.05 ENST00000373625.8
KPNA6
karyopherin subunit alpha 6
chr17_-_64263221 0.05 ENST00000258991.7
ENST00000583738.1
ENST00000584379.6
TEX2
testis expressed 2
chr9_-_125189721 0.05 ENST00000456642.1
ENST00000373547.9
ENST00000415905.5
ENST00000451402.5
PPP6C
protein phosphatase 6 catalytic subunit
chr9_+_88388356 0.04 ENST00000375859.4
SPIN1
spindlin 1
chr20_+_44475867 0.04 ENST00000262605.9
ENST00000372904.7
ENST00000372906.2
ENST00000456317.1
TTPAL
alpha tocopherol transfer protein like
chr19_-_45496998 0.04 ENST00000245923.9
ENST00000590526.5
ENST00000344680.8
RTN2
reticulon 2
chr6_-_11232658 0.04 ENST00000379433.5
ENST00000379446.10
ENST00000620854.4
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_66921217 0.04 ENST00000341567.8
ENST00000607045.5
TMEM248
transmembrane protein 248
chr10_+_100535927 0.04 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr1_+_87328860 0.04 ENST00000370544.10
LMO4
LIM domain only 4
chr16_+_69565958 0.04 ENST00000349945.7
ENST00000354436.6
NFAT5
nuclear factor of activated T cells 5
chr12_+_48818478 0.04 ENST00000547818.5
ENST00000301050.7
ENST00000547392.5
CACNB3
calcium voltage-gated channel auxiliary subunit beta 3
chr9_+_137618986 0.03 ENST00000462484.5
ENST00000630754.2
ENST00000460843.6
ENST00000626216.2
ENST00000629335.2
EHMT1
euchromatic histone lysine methyltransferase 1
chr2_+_84971093 0.03 ENST00000456682.1
ENST00000409785.9
KCMF1
potassium channel modulatory factor 1
chr7_+_90596281 0.03 ENST00000380050.8
CDK14
cyclin dependent kinase 14
chr12_+_94148553 0.03 ENST00000258526.9
PLXNC1
plexin C1
chr12_-_40106026 0.03 ENST00000280871.9
ENST00000380858.1
SLC2A13
solute carrier family 2 member 13
chr1_+_42380772 0.03 ENST00000431473.4
ENST00000410070.6
RIMKLA
ribosomal modification protein rimK like family member A
chr2_+_24491860 0.03 ENST00000406961.5
ENST00000405141.5
NCOA1
nuclear receptor coactivator 1
chr6_+_151690492 0.02 ENST00000404742.5
ENST00000440973.5
ESR1
estrogen receptor 1
chr13_-_77027147 0.02 ENST00000355619.10
FBXL3
F-box and leucine rich repeat protein 3
chr21_-_39313610 0.02 ENST00000342449.8
ENST00000341322.4
BRWD1
bromodomain and WD repeat domain containing 1
chr16_-_74607088 0.02 ENST00000565260.1
ENST00000447066.6
ENST00000205061.9
ENST00000422840.7
ENST00000627032.2
GLG1
golgi glycoprotein 1
chr12_-_43806249 0.01 ENST00000548315.5
ENST00000552521.5
ENST00000546662.5
ENST00000548403.1
ENST00000546506.5
ENST00000395510.7
TWF1
twinfilin actin binding protein 1
chr17_+_50346099 0.01 ENST00000017003.7
ENST00000509778.1
ENST00000507602.5
XYLT2
xylosyltransferase 2
chr1_-_109509680 0.01 ENST00000369864.5
ENST00000369862.1
AMIGO1
adhesion molecule with Ig like domain 1
chr10_-_96513911 0.01 ENST00000357947.4
TLL2
tolloid like 2
chr14_+_55051639 0.01 ENST00000395468.9
ENST00000622254.1
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1 like
chr2_-_9003657 0.01 ENST00000462696.1
ENST00000305997.8
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr6_+_112087576 0.00 ENST00000368656.7
ENST00000604268.1
FAM229B
family with sequence similarity 229 member B
chr1_+_40396766 0.00 ENST00000539317.2
SMAP2
small ArfGAP2
chr7_-_44885446 0.00 ENST00000395699.5
PURB
purine rich element binding protein B
chr18_+_50560070 0.00 ENST00000400384.7
ENST00000540640.3
ENST00000592595.5
MAPK4
mitogen-activated protein kinase 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070662 erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662)
0.3 1.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.4 GO:1904868 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.4 GO:0010752 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752)
0.1 0.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.3 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.1 0.4 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976)
0.0 0.3 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 1.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0036216 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0097135 X chromosome(GO:0000805) cyclin E2-CDK2 complex(GO:0097135)
0.0 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 1.1 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.8 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0000182 rDNA binding(GO:0000182)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation