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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ACUGGCC

Z-value: 0.25

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miRNA associated with seed ACUGGCC

NamemiRBASE accession
hsa-miR-193a-3p
MIMAT0000459
hsa-miR-193b-3p
MIMAT0002819

Activity profile of ACUGGCC motif

Sorted Z-values of ACUGGCC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ACUGGCC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_70169516 0.84 ENST00000243457.4
KCNJ2
potassium inwardly rectifying channel subfamily J member 2
chr4_+_54657918 0.80 ENST00000412167.6
ENST00000288135.6
KIT
KIT proto-oncogene, receptor tyrosine kinase
chr2_+_12716893 0.66 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr1_-_91886144 0.55 ENST00000212355.9
TGFBR3
transforming growth factor beta receptor 3
chr12_+_78864768 0.43 ENST00000261205.9
ENST00000457153.6
SYT1
synaptotagmin 1
chr8_-_92103217 0.37 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr6_-_16761447 0.32 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr3_-_125055987 0.28 ENST00000311127.9
HEG1
heart development protein with EGF like domains 1
chr6_+_85449584 0.27 ENST00000369651.7
NT5E
5'-nucleotidase ecto
chr22_-_39152622 0.25 ENST00000216133.10
CBX7
chromobox 7
chr18_-_55588184 0.23 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
TCF4
transcription factor 4
chr5_+_178113519 0.22 ENST00000274605.6
N4BP3
NEDD4 binding protein 3
chr11_+_128694052 0.20 ENST00000527786.7
ENST00000534087.3
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr20_-_5001474 0.19 ENST00000338244.6
SLC23A2
solute carrier family 23 member 2
chr1_+_76074698 0.18 ENST00000328299.4
ST6GALNAC3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr8_-_88327475 0.17 ENST00000286614.11
MMP16
matrix metallopeptidase 16
chr14_-_54489003 0.17 ENST00000554908.5
ENST00000616146.4
GMFB
glia maturation factor beta
chr10_+_95755652 0.16 ENST00000371207.8
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr4_+_125314918 0.15 ENST00000674496.2
ENST00000394329.9
FAT4
FAT atypical cadherin 4
chrX_-_24027186 0.14 ENST00000328046.8
KLHL15
kelch like family member 15
chr16_-_4116403 0.13 ENST00000294016.8
ADCY9
adenylate cyclase 9
chr12_-_31591129 0.12 ENST00000389082.10
DENND5B
DENN domain containing 5B
chr16_+_85613252 0.10 ENST00000253458.12
ENST00000393243.5
GSE1
Gse1 coiled-coil protein
chr2_+_203328378 0.10 ENST00000430418.5
ENST00000261018.12
ENST00000295851.10
ENST00000424558.5
ENST00000417864.5
ENST00000422511.6
ABI2
abl interactor 2
chr14_+_90397019 0.09 ENST00000447653.8
ENST00000356978.9
ENST00000626705.2
CALM1
calmodulin 1
chr1_-_9823953 0.09 ENST00000377298.9
ENST00000361311.4
CLSTN1
calsyntenin 1
chr18_+_48539017 0.09 ENST00000256413.8
CTIF
cap binding complex dependent translation initiation factor
chr6_-_75284736 0.09 ENST00000674038.1
ENST00000673730.1
ENST00000230461.11
TMEM30A
transmembrane protein 30A
chr11_-_46918522 0.08 ENST00000378623.6
ENST00000534404.1
LRP4
LDL receptor related protein 4
chr11_+_120336357 0.08 ENST00000397843.7
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr5_+_38846002 0.08 ENST00000274276.8
OSMR
oncostatin M receptor
chr19_-_14518383 0.08 ENST00000254322.3
ENST00000595139.2
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
chr6_-_47309898 0.07 ENST00000296861.2
TNFRSF21
TNF receptor superfamily member 21
chr10_-_92574027 0.07 ENST00000650060.1
ENST00000265986.11
ENST00000679089.1
ENST00000676540.1
ENST00000678673.1
ENST00000677079.1
IDE
insulin degrading enzyme
chr7_-_20786879 0.06 ENST00000418710.3
ENST00000617581.4
ENST00000361443.4
SP8
Sp8 transcription factor
chr14_-_50231570 0.06 ENST00000216373.10
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2
chr5_+_79236092 0.06 ENST00000396137.5
JMY
junction mediating and regulatory protein, p53 cofactor
chr2_-_207166818 0.06 ENST00000423015.5
KLF7
Kruppel like factor 7
chr1_-_150579530 0.05 ENST00000307940.3
ENST00000678610.1
ENST00000678770.1
ENST00000369026.3
MCL1
MCL1 apoptosis regulator, BCL2 family member
chr7_+_108569832 0.05 ENST00000249356.4
DNAJB9
DnaJ heat shock protein family (Hsp40) member B9
chr9_+_128882119 0.05 ENST00000372600.9
ENST00000372599.7
LRRC8A
leucine rich repeat containing 8 VRAC subunit A
chr11_-_27472698 0.05 ENST00000389858.4
ENST00000379214.9
LGR4
leucine rich repeat containing G protein-coupled receptor 4
chr15_-_61229297 0.05 ENST00000335670.11
RORA
RAR related orphan receptor A
chr1_+_183636065 0.05 ENST00000304685.8
RGL1
ral guanine nucleotide dissociation stimulator like 1
chr17_+_63622406 0.05 ENST00000579585.5
ENST00000361733.8
ENST00000584573.5
ENST00000361357.7
MAP3K3
mitogen-activated protein kinase kinase kinase 3
chr10_-_100519829 0.04 ENST00000370345.8
SEC31B
SEC31 homolog B, COPII coat complex component
chr14_+_56579782 0.04 ENST00000261556.11
ENST00000538838.5
TMEM260
transmembrane protein 260
chr7_-_143362687 0.04 ENST00000409578.5
ENST00000443739.7
ENST00000409346.5
FAM131B
family with sequence similarity 131 member B
chr2_-_38751350 0.04 ENST00000409276.5
ENST00000313117.11
ENST00000446327.6
SRSF7
serine and arginine rich splicing factor 7
chr9_-_37465402 0.04 ENST00000307750.5
ZBTB5
zinc finger and BTB domain containing 5
chr17_+_57256514 0.04 ENST00000284073.7
ENST00000674964.1
MSI2
musashi RNA binding protein 2
chr20_+_58651228 0.03 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
STX16
syntaxin 16
chrX_-_53225176 0.03 ENST00000404049.7
ENST00000375401.8
KDM5C
lysine demethylase 5C
chr22_+_24555981 0.03 ENST00000215829.8
ENST00000402849.5
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide
chr12_-_96400365 0.03 ENST00000261211.8
ENST00000543119.6
CDK17
cyclin dependent kinase 17
chr13_-_98752619 0.03 ENST00000376503.10
SLC15A1
solute carrier family 15 member 1
chr14_-_22982544 0.03 ENST00000262713.7
AJUBA
ajuba LIM protein
chr1_+_109249530 0.02 ENST00000271332.4
CELSR2
cadherin EGF LAG seven-pass G-type receptor 2
chr12_+_109999422 0.02 ENST00000261739.9
ANKRD13A
ankyrin repeat domain 13A
chr12_-_49903853 0.02 ENST00000320634.8
FAIM2
Fas apoptotic inhibitory molecule 2
chr22_+_24270776 0.02 ENST00000437398.5
ENST00000421374.5
ENST00000314328.14
ENST00000651059.1
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1 like
chr4_-_86360071 0.02 ENST00000641677.1
ENST00000639234.1
ENST00000641553.1
ENST00000641826.1
ENST00000641537.1
ENST00000395169.9
ENST00000641408.1
ENST00000638225.1
ENST00000641052.1
MAPK10
mitogen-activated protein kinase 10
chr2_+_241702027 0.02 ENST00000313552.11
ENST00000406941.5
ING5
inhibitor of growth family member 5
chr11_-_17014396 0.02 ENST00000355661.7
ENST00000532079.1
ENST00000531066.6
PLEKHA7
pleckstrin homology domain containing A7
chr13_+_98142552 0.02 ENST00000595437.5
FARP1
FERM, ARH/RhoGEF and pleckstrin domain protein 1
chr5_+_65926556 0.02 ENST00000380943.6
ENST00000416865.6
ENST00000380935.5
ENST00000284037.10
ERBIN
erbb2 interacting protein
chr2_-_197435002 0.02 ENST00000335508.11
ENST00000414963.2
ENST00000487698.5
SF3B1
splicing factor 3b subunit 1
chr13_+_110713640 0.02 ENST00000333219.9
ING1
inhibitor of growth family member 1
chr1_-_1307861 0.02 ENST00000354700.10
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr1_-_25906411 0.02 ENST00000455785.7
STMN1
stathmin 1
chr2_+_113173950 0.02 ENST00000245796.11
ENST00000441564.7
PSD4
pleckstrin and Sec7 domain containing 4
chr22_+_39994926 0.02 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr2_-_69643703 0.02 ENST00000406297.7
ENST00000409085.9
AAK1
AP2 associated kinase 1
chr6_+_39792993 0.01 ENST00000538976.5
DAAM2
dishevelled associated activator of morphogenesis 2
chr4_+_41990496 0.01 ENST00000264451.12
SLC30A9
solute carrier family 30 member 9
chr6_-_165662100 0.01 ENST00000366882.6
PDE10A
phosphodiesterase 10A
chr20_+_43457885 0.01 ENST00000668808.1
ENST00000670741.1
ENST00000662078.1
ENST00000244020.5
ENST00000657241.1
SRSF6
ENSG00000288000.1
serine and arginine rich splicing factor 6
novel protein
chr5_-_94618522 0.01 ENST00000513200.7
ENST00000329378.7
ENST00000682413.1
KIAA0825
KIAA0825
chr17_+_50719565 0.01 ENST00000625349.2
ENST00000393227.6
ENST00000240304.5
ENST00000505658.6
ENST00000505619.5
ENST00000510984.5
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr14_-_77028663 0.01 ENST00000238647.5
IRF2BPL
interferon regulatory factor 2 binding protein like
chr1_+_203795614 0.01 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr14_+_101761786 0.01 ENST00000422945.6
ENST00000554442.5
ENST00000556260.6
ENST00000328724.9
ENST00000557268.5
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr2_-_216695540 0.01 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr10_+_73911104 0.01 ENST00000446342.5
ENST00000372764.4
PLAU
plasminogen activator, urokinase
chr2_-_131093378 0.01 ENST00000409185.5
ENST00000389915.4
FAM168B
family with sequence similarity 168 member B
chr7_-_35254074 0.01 ENST00000408931.4
TBX20
T-box transcription factor 20
chr11_-_72112750 0.01 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr15_+_64151706 0.01 ENST00000325881.9
SNX22
sorting nexin 22
chr17_-_76737321 0.00 ENST00000359995.10
ENST00000508921.7
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
SRSF2
serine and arginine rich splicing factor 2
chr8_-_94949350 0.00 ENST00000448464.6
ENST00000342697.5
TP53INP1
tumor protein p53 inducible nuclear protein 1
chr12_+_56230043 0.00 ENST00000424625.5
ENST00000419753.5
ENST00000454355.7
ENST00000417965.5
ENST00000436633.5
SLC39A5
solute carrier family 39 member 5
chr2_-_206086057 0.00 ENST00000403263.6
INO80D
INO80 complex subunit D
chr3_+_132417487 0.00 ENST00000260818.11
DNAJC13
DnaJ heat shock protein family (Hsp40) member C13
chr17_-_68291116 0.00 ENST00000327268.8
ENST00000580666.6
SLC16A6
solute carrier family 16 member 6
chr11_+_34051722 0.00 ENST00000341394.9
ENST00000389645.7
CAPRIN1
cell cycle associated protein 1
chr1_-_169893876 0.00 ENST00000367771.11
ENST00000367772.8
SCYL3
SCY1 like pseudokinase 3
chr7_-_26864573 0.00 ENST00000345317.7
SKAP2
src kinase associated phosphoprotein 2
chr1_+_25800181 0.00 ENST00000361547.7
ENST00000374315.1
ENST00000354177.9
SELENON
selenoprotein N

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070662 erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662)
0.2 0.8 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 0.7 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.4 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.6 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.2 GO:0070904 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.3 GO:0046086 AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086)
0.0 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.1 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.0 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.4 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.2 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.7 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism