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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for AGCAGCG

Z-value: 0.65

Motif logo

logo of

miRNA associated with seed AGCAGCG

NamemiRBASE accession
hsa-miR-503-5p
MIMAT0002874

Activity profile of AGCAGCG motif

Sorted Z-values of AGCAGCG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AGCAGCG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_76023489 3.43 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr1_+_65147514 2.10 ENST00000545314.5
AK4
adenylate kinase 4
chr3_-_123884290 2.02 ENST00000346322.9
ENST00000360772.7
ENST00000360304.8
MYLK
myosin light chain kinase
chr8_+_23528947 1.58 ENST00000519973.6
SLC25A37
solute carrier family 25 member 37
chr4_+_127782270 1.34 ENST00000508549.5
ENST00000296464.9
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr4_+_20251896 1.29 ENST00000504154.6
SLIT2
slit guidance ligand 2
chr7_-_139777986 1.09 ENST00000406875.8
HIPK2
homeodomain interacting protein kinase 2
chr22_-_41621014 0.95 ENST00000263256.7
DESI1
desumoylating isopeptidase 1
chr12_+_4273751 0.90 ENST00000675880.1
ENST00000261254.8
CCND2
cyclin D2
chr15_+_66386902 0.90 ENST00000307102.10
MAP2K1
mitogen-activated protein kinase kinase 1
chr9_+_116153783 0.89 ENST00000328252.4
PAPPA
pappalysin 1
chr4_+_25234003 0.84 ENST00000264864.8
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chr6_+_127118657 0.83 ENST00000356698.9
RSPO3
R-spondin 3
chr1_+_184386978 0.78 ENST00000235307.7
C1orf21
chromosome 1 open reading frame 21
chr15_+_58771280 0.77 ENST00000559228.6
ENST00000450403.3
MINDY2
MINDY lysine 48 deubiquitinase 2
chr5_+_68215738 0.76 ENST00000521381.6
ENST00000521657.5
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr3_-_179071742 0.69 ENST00000311417.7
ENST00000652290.1
ZMAT3
zinc finger matrin-type 3
chr17_-_64662290 0.68 ENST00000262435.14
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr3_-_112499457 0.66 ENST00000334529.10
BTLA
B and T lymphocyte associated
chrX_-_103832204 0.64 ENST00000674363.1
ENST00000674162.1
ENST00000674338.1
ENST00000674274.1
ENST00000674271.1
ENST00000674265.1
ENST00000674212.1
ENST00000674255.1
ENST00000674342.1
ENST00000674430.1
ENST00000243298.3
ENSG00000288597.1
RAB9B
novel transcript
RAB9B, member RAS oncogene family
chr7_+_90403386 0.63 ENST00000287916.8
ENST00000394604.5
ENST00000496677.6
ENST00000394605.2
ENST00000480135.1
CLDN12
ENSG00000273299.1
claudin 12
novel transcript
chr17_+_59155726 0.60 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chr9_-_27529705 0.52 ENST00000262244.6
MOB3B
MOB kinase activator 3B
chr5_-_16465757 0.52 ENST00000308683.3
ZNF622
zinc finger protein 622
chr8_+_25459190 0.51 ENST00000380665.3
ENST00000330560.8
CDCA2
cell division cycle associated 2
chr20_-_32483438 0.50 ENST00000359676.9
NOL4L
nucleolar protein 4 like
chr18_-_48950960 0.48 ENST00000262158.8
SMAD7
SMAD family member 7
chr20_+_50731571 0.48 ENST00000371610.7
PARD6B
par-6 family cell polarity regulator beta
chr1_-_22143088 0.47 ENST00000290167.11
WNT4
Wnt family member 4
chr11_-_73142032 0.43 ENST00000311172.11
ENST00000409314.5
FCHSD2
FCH and double SH3 domains 2
chr1_-_243850070 0.41 ENST00000366539.6
ENST00000672578.1
AKT3
AKT serine/threonine kinase 3
chr4_-_68349981 0.41 ENST00000510746.1
ENST00000355665.7
ENST00000344157.9
YTHDC1
YTH domain containing 1
chr1_+_26826682 0.41 ENST00000374142.9
ZDHHC18
zinc finger DHHC-type palmitoyltransferase 18
chr15_+_69414304 0.40 ENST00000352331.8
ENST00000679126.1
ENST00000647715.1
ENST00000559279.6
KIF23
kinesin family member 23
chr16_-_48610150 0.40 ENST00000262384.4
N4BP1
NEDD4 binding protein 1
chr3_-_48188356 0.40 ENST00000351231.7
ENST00000437972.1
ENST00000302506.8
CDC25A
cell division cycle 25A
chr4_-_98929092 0.40 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr19_-_17688326 0.38 ENST00000552293.5
ENST00000551649.5
ENST00000519716.7
ENST00000550896.1
UNC13A
unc-13 homolog A
chr22_+_45163910 0.38 ENST00000347635.9
ENST00000407019.6
ENST00000424634.5
ENST00000417702.5
ENST00000430547.5
NUP50
nucleoporin 50
chr11_-_65900413 0.37 ENST00000448083.6
ENST00000531493.5
ENST00000532401.1
FOSL1
FOS like 1, AP-1 transcription factor subunit
chr7_-_99144053 0.36 ENST00000361125.1
ENST00000361368.7
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr9_-_92670124 0.34 ENST00000287996.8
IPPK
inositol-pentakisphosphate 2-kinase
chr18_+_32091849 0.34 ENST00000261593.8
ENST00000578914.1
RNF138
ring finger protein 138
chr1_+_47333774 0.33 ENST00000371873.10
CMPK1
cytidine/uridine monophosphate kinase 1
chr14_-_105021043 0.33 ENST00000392590.3
ENST00000336219.4
CDCA4
cell division cycle associated 4
chr18_+_57352541 0.32 ENST00000324000.4
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr20_-_53593829 0.32 ENST00000371471.7
ZNF217
zinc finger protein 217
chr3_-_13880059 0.29 ENST00000285018.5
WNT7A
Wnt family member 7A
chr2_-_46462 0.29 ENST00000327669.5
FAM110C
family with sequence similarity 110 member C
chr7_+_36389852 0.29 ENST00000265748.7
ANLN
anillin actin binding protein
chr2_+_197515565 0.28 ENST00000233892.8
ENST00000409916.5
MOB4
MOB family member 4, phocein
chr22_+_39502237 0.28 ENST00000325301.7
MIEF1
mitochondrial elongation factor 1
chr4_+_183905266 0.28 ENST00000308497.9
STOX2
storkhead box 2
chr11_+_9384621 0.26 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
IPO7
importin 7
chr11_-_61161414 0.26 ENST00000301765.10
VPS37C
VPS37C subunit of ESCRT-I
chr2_+_167868948 0.25 ENST00000392690.3
B3GALT1
beta-1,3-galactosyltransferase 1
chr16_-_46973634 0.25 ENST00000317089.10
DNAJA2
DnaJ heat shock protein family (Hsp40) member A2
chr10_-_59906509 0.24 ENST00000263102.7
CCDC6
coiled-coil domain containing 6
chr1_-_52366124 0.24 ENST00000371586.6
ENST00000284376.8
CC2D1B
coiled-coil and C2 domain containing 1B
chr5_+_151771884 0.24 ENST00000627077.2
ENST00000678976.1
ENST00000677408.1
ENST00000678070.1
ENST00000678964.1
ENST00000678925.1
ENST00000394123.7
ENST00000522761.6
ENST00000676827.1
G3BP1
G3BP stress granule assembly factor 1
chr1_+_162497805 0.23 ENST00000538489.5
ENST00000489294.2
UHMK1
U2AF homology motif kinase 1
chr12_-_7936177 0.23 ENST00000544291.1
ENST00000075120.12
SLC2A3
solute carrier family 2 member 3
chrX_+_96684801 0.23 ENST00000324765.13
DIAPH2
diaphanous related formin 2
chr1_+_77779618 0.23 ENST00000370791.7
ENST00000443751.3
ENST00000645756.1
ENST00000643390.1
ENST00000642959.1
MIGA1
mitoguardin 1
chr9_-_125143457 0.22 ENST00000373549.8
ENST00000336505.11
SCAI
suppressor of cancer cell invasion
chr17_-_29294141 0.22 ENST00000225388.9
NUFIP2
nuclear FMR1 interacting protein 2
chr3_+_196867856 0.20 ENST00000445299.6
ENST00000323460.10
ENST00000419026.5
SENP5
SUMO specific peptidase 5
chr11_-_119729158 0.19 ENST00000264025.8
NECTIN1
nectin cell adhesion molecule 1
chr7_-_99438647 0.19 ENST00000430029.1
ENST00000419981.1
ENST00000292478.9
PTCD1
pentatricopeptide repeat domain 1
chr17_+_4997901 0.19 ENST00000320785.10
ENST00000574165.1
KIF1C
kinesin family member 1C
chr4_+_71339014 0.19 ENST00000340595.4
SLC4A4
solute carrier family 4 member 4
chr12_-_7872843 0.18 ENST00000340749.9
ENST00000535295.5
ENST00000539234.5
SLC2A14
solute carrier family 2 member 14
chr10_-_118754956 0.17 ENST00000369151.8
CACUL1
CDK2 associated cullin domain 1
chr13_+_108269629 0.17 ENST00000430559.5
ENST00000375887.9
TNFSF13B
TNF superfamily member 13b
chr2_+_200811882 0.16 ENST00000409600.6
BZW1
basic leucine zipper and W2 domains 1
chr10_+_86756580 0.16 ENST00000372037.8
BMPR1A
bone morphogenetic protein receptor type 1A
chr5_+_96662214 0.15 ENST00000395812.6
CAST
calpastatin
chr7_+_141074038 0.15 ENST00000565468.6
ENST00000610315.1
TMEM178B
transmembrane protein 178B
chr2_-_72147819 0.15 ENST00000001146.7
ENST00000546307.5
ENST00000474509.1
CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr11_+_125626229 0.15 ENST00000532449.6
ENST00000534070.5
CHEK1
checkpoint kinase 1
chr11_+_77589911 0.14 ENST00000313578.4
AQP11
aquaporin 11
chr8_+_94641145 0.14 ENST00000433389.8
ENST00000358397.9
ESRP1
epithelial splicing regulatory protein 1
chr1_+_35931076 0.13 ENST00000397828.3
ENST00000373191.9
AGO3
argonaute RISC catalytic component 3
chr6_-_96837460 0.13 ENST00000229955.4
GPR63
G protein-coupled receptor 63
chr16_+_50548387 0.13 ENST00000268459.6
NKD1
NKD inhibitor of WNT signaling pathway 1
chr2_+_207711631 0.13 ENST00000295414.8
ENST00000420822.1
ENST00000339882.9
CCNYL1
cyclin Y like 1
chr11_+_65014103 0.13 ENST00000246747.9
ENST00000529384.5
ENST00000533729.1
ARL2
ADP ribosylation factor like GTPase 2
chr1_+_38991239 0.13 ENST00000432648.8
ENST00000446189.6
ENST00000372984.8
AKIRIN1
akirin 1
chr8_-_91040814 0.13 ENST00000520014.1
ENST00000285419.8
PIP4P2
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr10_+_93893931 0.13 ENST00000371408.7
ENST00000427197.2
SLC35G1
solute carrier family 35 member G1
chr12_-_107761113 0.13 ENST00000228437.10
PRDM4
PR/SET domain 4
chr2_+_203706614 0.13 ENST00000324106.9
CD28
CD28 molecule
chr12_-_112382363 0.12 ENST00000682272.1
ENST00000377560.9
HECTD4
HECT domain E3 ubiquitin protein ligase 4
chr6_+_47477731 0.12 ENST00000359314.5
CD2AP
CD2 associated protein
chr16_+_30699155 0.12 ENST00000262518.9
SRCAP
Snf2 related CREBBP activator protein
chr12_+_54497712 0.12 ENST00000293373.11
NCKAP1L
NCK associated protein 1 like
chr2_+_46698909 0.12 ENST00000650611.1
ENST00000306503.5
LINC01118
SOCS5
long intergenic non-protein coding RNA 1118
suppressor of cytokine signaling 5
chr5_+_73498408 0.11 ENST00000335895.12
ENST00000678135.1
ENST00000380591.7
ENST00000677654.1
ENST00000507081.6
BTF3
basic transcription factor 3
chr3_+_10816201 0.11 ENST00000454147.1
ENST00000254488.7
SLC6A11
solute carrier family 6 member 11
chr15_+_49423233 0.11 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr4_+_165873231 0.10 ENST00000061240.7
TLL1
tolloid like 1
chr10_-_117375407 0.10 ENST00000334464.7
PDZD8
PDZ domain containing 8
chr16_+_67846917 0.10 ENST00000219169.9
ENST00000567105.5
NUTF2
nuclear transport factor 2
chr4_+_93828746 0.10 ENST00000306011.6
ATOH1
atonal bHLH transcription factor 1
chr12_+_57550027 0.10 ENST00000674619.1
ENST00000676359.1
ENST00000286452.5
ENST00000455537.7
ENST00000676457.1
KIF5A
kinesin family member 5A
chr19_-_50637939 0.10 ENST00000338916.8
SYT3
synaptotagmin 3
chr1_+_15526813 0.09 ENST00000375838.5
ENST00000616884.4
ENST00000375849.5
ENST00000375847.8
DNAJC16
DnaJ heat shock protein family (Hsp40) member C16
chr4_-_41748713 0.09 ENST00000226382.4
PHOX2B
paired like homeobox 2B
chr5_+_154712824 0.09 ENST00000336314.9
LARP1
La ribonucleoprotein 1, translational regulator
chr15_+_74173693 0.08 ENST00000249842.8
ISLR
immunoglobulin superfamily containing leucine rich repeat
chr17_+_79778135 0.08 ENST00000310942.9
ENST00000269399.5
CBX2
chromobox 2
chr18_-_63319987 0.07 ENST00000398117.1
BCL2
BCL2 apoptosis regulator
chr18_+_70288991 0.07 ENST00000397942.4
SOCS6
suppressor of cytokine signaling 6
chr3_-_129688691 0.07 ENST00000432054.6
TMCC1
transmembrane and coiled-coil domain family 1
chr12_-_14803462 0.07 ENST00000261167.7
ENST00000535328.1
WBP11
WW domain binding protein 11
chr10_+_102918276 0.07 ENST00000369878.9
ENST00000369875.3
CNNM2
cyclin and CBS domain divalent metal cation transport mediator 2
chr19_+_49119531 0.07 ENST00000334186.9
PPFIA3
PTPRF interacting protein alpha 3
chr10_-_73495966 0.06 ENST00000342558.3
ENST00000360663.10
ENST00000394828.6
ENST00000394829.6
PPP3CB
protein phosphatase 3 catalytic subunit beta
chrX_+_49922605 0.06 ENST00000376088.7
CLCN5
chloride voltage-gated channel 5
chr12_+_57755060 0.06 ENST00000266643.6
MARCHF9
membrane associated ring-CH-type finger 9
chr1_-_207051202 0.06 ENST00000315927.9
YOD1
YOD1 deubiquitinase
chr9_+_4679555 0.06 ENST00000381858.5
ENST00000381854.4
CDC37L1
cell division cycle 37 like 1
chr5_+_79612410 0.06 ENST00000423041.6
ENST00000504233.5
ENST00000453514.6
ENST00000428308.6
TENT2
terminal nucleotidyltransferase 2
chr5_+_72816643 0.05 ENST00000337273.10
ENST00000523768.5
TNPO1
transportin 1
chr5_-_133612524 0.05 ENST00000265342.12
FSTL4
follistatin like 4
chr14_+_30559142 0.05 ENST00000550944.5
ENST00000438909.6
ENST00000206595.11
ENST00000553504.5
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr15_+_38252792 0.05 ENST00000299084.9
SPRED1
sprouty related EVH1 domain containing 1
chr3_+_189171948 0.05 ENST00000345063.8
TPRG1
tumor protein p63 regulated 1
chr14_+_52730154 0.05 ENST00000354586.5
ENST00000442123.6
STYX
serine/threonine/tyrosine interacting protein
chr1_-_23980308 0.05 ENST00000374452.9
ENST00000492112.3
ENST00000343255.9
ENST00000344989.10
SRSF10
serine and arginine rich splicing factor 10
chr12_-_54280087 0.04 ENST00000209875.9
CBX5
chromobox 5
chr3_+_49554436 0.04 ENST00000296452.5
BSN
bassoon presynaptic cytomatrix protein
chr2_+_148875214 0.04 ENST00000435030.6
ENST00000677891.1
ENST00000677843.1
ENST00000678056.1
ENST00000677280.1
KIF5C
kinesin family member 5C
chr7_+_30284574 0.04 ENST00000323037.5
ZNRF2
zinc and ring finger 2
chr6_-_44297672 0.04 ENST00000371505.5
TCTE1
t-complex-associated-testis-expressed 1
chr9_+_68780029 0.04 ENST00000394264.7
PABIR1
PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1
chr7_+_4682252 0.04 ENST00000328914.5
FOXK1
forkhead box K1
chr3_-_120349294 0.04 ENST00000295628.4
LRRC58
leucine rich repeat containing 58
chr3_+_38453832 0.03 ENST00000352511.5
ACVR2B
activin A receptor type 2B
chr18_-_32470484 0.03 ENST00000399218.8
GAREM1
GRB2 associated regulator of MAPK1 subtype 1
chr2_+_231037500 0.03 ENST00000373640.5
C2orf72
chromosome 2 open reading frame 72
chr11_-_126268810 0.02 ENST00000332118.11
SRPRA
SRP receptor subunit alpha
chr1_+_109494052 0.02 ENST00000393709.3
ENST00000496961.5
ENST00000533024.5
ENST00000420578.7
ENST00000310611.8
ENST00000527072.5
ENST00000528785.1
ENST00000369868.7
ENST00000430195.2
CYB561D1
cytochrome b561 family member D1
chr9_-_35732122 0.02 ENST00000314888.10
TLN1
talin 1
chr2_+_61017562 0.01 ENST00000401576.1
ENST00000295030.6
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr2_-_121285194 0.01 ENST00000263707.6
TFCP2L1
transcription factor CP2 like 1
chr17_-_67245165 0.00 ENST00000580168.5
ENST00000358691.10
HELZ
helicase with zinc finger
chr5_-_39074377 0.00 ENST00000514735.1
ENST00000357387.8
ENST00000296782.9
RICTOR
RPTOR independent companion of MTOR complex 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.4 1.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.3 3.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.3 2.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 2.4 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.2 0.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 0.5 GO:0061184 positive regulation of dermatome development(GO:0061184) renal vesicle induction(GO:0072034) positive regulation of steroid hormone biosynthetic process(GO:0090031) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.9 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.1 0.4 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 1.1 GO:0060235 voluntary musculoskeletal movement(GO:0050882) lens induction in camera-type eye(GO:0060235)
0.1 0.3 GO:1904172 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.5 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:1902809 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.3 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.2 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.0 0.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:0048377 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.4 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.9 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.0 0.1 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.1 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.3 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.8 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.0 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 0.2 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.0 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.4 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 1.1 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.2 0.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.4 GO:0044305 calyx of Held(GO:0044305)
0.0 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:1990742 microvesicle(GO:1990742)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 2.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 2.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.3 GO:0043237 laminin-1 binding(GO:0043237) Roundabout binding(GO:0048495)
0.1 0.8 GO:0070004 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.1 0.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 1.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.3 GO:0046790 virion binding(GO:0046790)
0.1 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.3 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 3.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint