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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for AR_NR3C2

Z-value: 0.64

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.18 AR
NR3C2
ENSG00000151623.15 NR3C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg38_v1_chrX_+_67543973_67544054-0.154.6e-01Click!
NR3C2hg38_v1_chr4_-_148442342_148442431,
hg38_v1_chr4_-_148444674_148444756,
hg38_v1_chr4_-_148442508_148442526		0.135.4e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_112978562 2.74 ENST00000680122.1
OAS2
2'-5'-oligoadenylate synthetase 2
chr20_-_45547420 1.27 ENST00000504988.1
EPPIN-WFDC6
EPPIN-WFDC6 readthrough
chr20_-_45547648 1.25 ENST00000651288.1
EPPIN-WFDC6
EPPIN-WFDC6 readthrough
chr16_+_56625775 1.22 ENST00000330439.7
ENST00000568293.1
MT1E
metallothionein 1E
chrX_-_8171267 1.20 ENST00000317103.5
VCX2
variable charge X-linked 2
chr6_+_127577168 1.13 ENST00000329722.8
C6orf58
chromosome 6 open reading frame 58
chr16_+_56608577 1.10 ENST00000245185.6
ENST00000561491.1
MT2A
metallothionein 2A
chr16_+_56682461 1.08 ENST00000562939.1
ENST00000394485.5
ENST00000567563.1
MT1X
ENSG00000259827.1
metallothionein 1X
novel transcript
chr3_-_58577367 0.97 ENST00000464064.5
ENST00000360997.7
FAM107A
family with sequence similarity 107 member A
chr3_-_58577648 0.96 ENST00000394481.5
FAM107A
family with sequence similarity 107 member A
chr2_+_102337148 0.94 ENST00000311734.6
ENST00000409584.5
IL1RL1
interleukin 1 receptor like 1
chr9_-_35563867 0.88 ENST00000399742.7
ENST00000619051.4
FAM166B
family with sequence similarity 166 member B
chr12_+_5043873 0.87 ENST00000252321.5
KCNA5
potassium voltage-gated channel subfamily A member 5
chr20_-_45547752 0.84 ENST00000409554.1
EPPIN
epididymal peptidase inhibitor
chr16_+_56632651 0.72 ENST00000379818.4
ENST00000570233.1
MT1M
metallothionein 1M
chr19_+_8052752 0.71 ENST00000315626.6
ENST00000253451.9
CCL25
C-C motif chemokine ligand 25
chrX_+_8465426 0.68 ENST00000381029.4
VCX3B
variable charge X-linked 3B
chr19_+_35140022 0.66 ENST00000588081.5
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35139440 0.65 ENST00000455515.6
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35139724 0.64 ENST00000588715.5
ENST00000588607.5
FXYD1
FXYD domain containing ion transport regulator 1
chrX_+_8464830 0.64 ENST00000453306.4
ENST00000381032.6
ENST00000444481.3
VCX3B
variable charge X-linked 3B
chr19_+_8053000 0.57 ENST00000390669.7
CCL25
C-C motif chemokine ligand 25
chr19_-_14835162 0.55 ENST00000322301.5
OR7A5
olfactory receptor family 7 subfamily A member 5
chr1_+_145719483 0.52 ENST00000369288.7
CD160
CD160 molecule
chrY_-_13986473 0.51 ENST00000250825.5
VCY
variable charge Y-linked
chr11_+_47980538 0.51 ENST00000613246.4
ENST00000418331.7
ENST00000615445.4
ENST00000440289.6
PTPRJ
protein tyrosine phosphatase receptor type J
chr17_-_8152380 0.46 ENST00000317276.9
PER1
period circadian regulator 1
chr14_+_24147474 0.46 ENST00000324103.11
ENST00000559260.5
RNF31
ring finger protein 31
chrY_+_14056226 0.45 ENST00000250823.5
VCY1B
variable charge Y-linked 1B
chr1_+_1915080 0.45 ENST00000378604.3
CALML6
calmodulin like 6
chr14_-_23154369 0.43 ENST00000453702.5
SLC7A8
solute carrier family 7 member 8
chrX_+_7843088 0.43 ENST00000341408.5
VCX
variable charge X-linked
chr8_-_71844402 0.42 ENST00000325509.5
MSC
musculin
chr8_-_22156789 0.40 ENST00000306317.7
LGI3
leucine rich repeat LGI family member 3
chrX_-_6535118 0.35 ENST00000381089.7
ENST00000612369.4
ENST00000398729.1
VCX3A
variable charge X-linked 3A
chr1_+_145719468 0.35 ENST00000616463.1
CD160
CD160 molecule
chr14_-_106675544 0.35 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr6_+_122996227 0.31 ENST00000275162.10
CLVS2
clavesin 2
chr16_+_56638659 0.31 ENST00000290705.12
MT1A
metallothionein 1A
chr20_-_45547373 0.28 ENST00000354280.9
EPPIN
epididymal peptidase inhibitor
chr6_+_31670379 0.27 ENST00000409525.1
LY6G5B
lymphocyte antigen 6 family member G5B
chr8_-_48921419 0.27 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr2_-_74648307 0.25 ENST00000421985.2
ENST00000536235.5
M1AP
meiosis 1 associated protein
chr9_+_128920966 0.24 ENST00000428610.5
ENST00000372592.8
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr8_-_21812320 0.24 ENST00000517328.5
GFRA2
GDNF family receptor alpha 2
chr5_-_150412743 0.24 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr3_-_190449782 0.24 ENST00000354905.3
TMEM207
transmembrane protein 207
chr2_+_190180835 0.23 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr1_-_48776811 0.23 ENST00000371833.4
BEND5
BEN domain containing 5
chr8_+_24440930 0.23 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM7
ADAM metallopeptidase domain 7
chr19_-_8343255 0.22 ENST00000330915.7
ENST00000593649.5
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr12_-_10098977 0.20 ENST00000315330.8
ENST00000457018.6
CLEC1A
C-type lectin domain family 1 member A
chr7_-_97024821 0.19 ENST00000648378.1
ENST00000486603.2
DLX5
distal-less homeobox 5
chr17_-_63873676 0.19 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
CSH2
chorionic somatomammotropin hormone 2
chr15_+_40569290 0.19 ENST00000315616.12
ENST00000559271.1
ENST00000616318.1
RPUSD2
RNA pseudouridine synthase domain containing 2
chr18_-_50819764 0.19 ENST00000592966.5
MRO
maestro
chr19_-_3786254 0.18 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr4_-_68349981 0.17 ENST00000510746.1
ENST00000355665.7
ENST00000344157.9
YTHDC1
YTH domain containing 1
chr3_-_108757407 0.17 ENST00000295755.7
RETNLB
resistin like beta
chr19_-_3786408 0.16 ENST00000395040.6
MATK
megakaryocyte-associated tyrosine kinase
chr11_-_75669028 0.16 ENST00000304771.8
MAP6
microtubule associated protein 6
chr2_+_237487239 0.15 ENST00000338530.8
ENST00000264605.8
ENST00000409373.5
MLPH
melanophilin
chr19_-_3786363 0.15 ENST00000310132.11
MATK
megakaryocyte-associated tyrosine kinase
chr12_+_121803991 0.14 ENST00000604567.6
ENST00000542440.5
SETD1B
SET domain containing 1B, histone lysine methyltransferase
chr19_-_14835252 0.13 ENST00000641666.1
ENST00000642030.1
ENST00000642000.1
OR7C1
olfactory receptor family 7 subfamily C member 1
chr3_+_169773384 0.13 ENST00000349841.10
ENST00000356716.8
MYNN
myoneurin
chr17_-_63896621 0.13 ENST00000453363.7
CSH1
chorionic somatomammotropin hormone 1
chr8_-_144409282 0.13 ENST00000620219.4
ENST00000616140.2
CPSF1
cleavage and polyadenylation specific factor 1
chr19_+_55676621 0.12 ENST00000411543.6
EPN1
epsin 1
chr11_+_8911280 0.12 ENST00000530281.5
ENST00000396648.6
ENST00000534147.5
ENST00000529942.1
AKIP1
A-kinase interacting protein 1
chr1_+_93345893 0.11 ENST00000370272.9
ENST00000370267.1
DR1
down-regulator of transcription 1
chr3_-_119146014 0.11 ENST00000441144.6
ENST00000425327.6
IGSF11
immunoglobulin superfamily member 11
chr19_+_58059236 0.10 ENST00000359978.10
ENST00000401053.8
ENST00000511556.5
ENST00000506786.1
ENST00000313434.10
ZNF135
zinc finger protein 135
chr2_-_37324826 0.10 ENST00000234179.8
PRKD3
protein kinase D3
chr5_-_173616588 0.10 ENST00000285908.5
ENST00000311086.9
ENST00000480951.1
BOD1
biorientation of chromosomes in cell division 1
chr11_+_8911154 0.10 ENST00000309357.8
ENST00000529876.5
ENST00000309377.9
ENST00000525005.5
ENST00000524577.5
ENST00000534506.5
AKIP1
A-kinase interacting protein 1
chr12_+_66189178 0.09 ENST00000545837.1
IRAK3
interleukin 1 receptor associated kinase 3
chr11_-_236326 0.09 ENST00000525237.1
ENST00000382743.9
ENST00000532956.5
ENST00000525319.5
ENST00000524564.5
SIRT3
sirtuin 3
chr12_-_56454653 0.09 ENST00000652304.1
MIP
major intrinsic protein of lens fiber
chr4_-_68349750 0.08 ENST00000579690.5
YTHDC1
YTH domain containing 1
chr18_-_50819982 0.08 ENST00000398439.8
ENST00000431965.6
ENST00000436348.6
MRO
maestro
chr14_-_106658251 0.08 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr14_-_106411021 0.08 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chr11_+_8911106 0.08 ENST00000299576.9
AKIP1
A-kinase interacting protein 1
chr9_+_69035729 0.08 ENST00000642889.1
ENST00000646862.1
ENST00000484259.3
ENST00000396366.6
ENSG00000285130.2
FXN
novel protein
frataxin
chr18_+_63542365 0.07 ENST00000269491.6
ENST00000382768.2
SERPINB12
serpin family B member 12
chr14_+_73886617 0.07 ENST00000540593.5
ENST00000555730.6
ZNF410
zinc finger protein 410
chr14_-_23154422 0.07 ENST00000422941.6
SLC7A8
solute carrier family 7 member 8
chr2_+_241637682 0.06 ENST00000419606.5
ENST00000404914.8
ENST00000400771.7
ATG4B
autophagy related 4B cysteine peptidase
chr1_+_22653189 0.06 ENST00000432749.6
C1QB
complement C1q B chain
chr14_-_21025490 0.06 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG2
NDRG family member 2
chr1_+_75796867 0.06 ENST00000263187.4
MSH4
mutS homolog 4
chr17_-_63896568 0.05 ENST00000610991.1
ENST00000316193.13
ENST00000329882.8
CSH1
chorionic somatomammotropin hormone 1
chr14_+_21852457 0.05 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr2_-_201769759 0.05 ENST00000680163.1
ENST00000680188.1
ENST00000679550.1
ALS2
alsin Rho guanine nucleotide exchange factor ALS2
chr11_-_506739 0.04 ENST00000529306.5
ENST00000438658.6
ENST00000527485.5
ENST00000397615.6
ENST00000397614.5
RNH1
ribonuclease/angiogenin inhibitor 1
chr1_+_22653228 0.04 ENST00000509305.6
C1QB
complement C1q B chain
chr2_-_230960954 0.04 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr4_-_185425941 0.04 ENST00000264689.11
ENST00000505357.1
UFSP2
UFM1 specific peptidase 2
chr2_+_241637612 0.04 ENST00000625810.2
ENST00000402096.5
ATG4B
autophagy related 4B cysteine peptidase
chr2_+_190180447 0.04 ENST00000409870.1
C2orf88
chromosome 2 open reading frame 88
chr14_-_106803221 0.03 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr4_-_75672868 0.03 ENST00000678123.1
ENST00000678578.1
ENST00000677876.1
ENST00000676839.1
ENST00000678265.1
G3BP2
G3BP stress granule assembly factor 2
chr16_-_737771 0.03 ENST00000568545.5
CIAO3
cytosolic iron-sulfur assembly component 3
chr5_-_180071708 0.03 ENST00000522208.6
ENST00000521389.6
RNF130
ring finger protein 130
chr20_+_15196834 0.03 ENST00000402914.5
MACROD2
mono-ADP ribosylhydrolase 2
chr12_+_66189208 0.03 ENST00000261233.9
IRAK3
interleukin 1 receptor associated kinase 3
chr19_-_42412347 0.03 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chr4_+_37891060 0.03 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1D1
TBC1 domain family member 1
chr2_+_190180930 0.02 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chrX_+_2691284 0.02 ENST00000381192.10
CD99
CD99 molecule (Xg blood group)
chr16_+_8642375 0.02 ENST00000562973.1
METTL22
methyltransferase like 22
chr17_+_43171187 0.02 ENST00000542611.5
ENST00000590996.6
ENST00000589872.1
NBR1
NBR1 autophagy cargo receptor
chr22_+_21567705 0.02 ENST00000342192.9
UBE2L3
ubiquitin conjugating enzyme E2 L3
chrX_+_2691164 0.02 ENST00000611428.5
CD99
CD99 molecule (Xg blood group)
chr11_-_506316 0.02 ENST00000532055.5
ENST00000531540.5
RNH1
ribonuclease/angiogenin inhibitor 1
chr2_-_241637045 0.02 ENST00000407315.6
THAP4
THAP domain containing 4
chrX_-_18220878 0.02 ENST00000380033.9
BEND2
BEN domain containing 2
chrX_-_24027186 0.01 ENST00000328046.8
KLHL15
kelch like family member 15
chr1_-_10796636 0.01 ENST00000377022.8
ENST00000344008.5
CASZ1
castor zinc finger 1
chrX_+_2691310 0.01 ENST00000482405.7
ENST00000624481.4
ENST00000381180.9
CD99
CD99 molecule (Xg blood group)
chr3_+_119146159 0.01 ENST00000295622.6
TEX55
testis expressed 55
chr16_-_66550142 0.01 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
TK2
thymidine kinase 2
chr16_-_67944113 0.01 ENST00000264005.10
LCAT
lecithin-cholesterol acyltransferase
chrX_+_2691270 0.00 ENST00000381187.8
ENST00000381184.6
CD99
CD99 molecule (Xg blood group)
chr19_+_15010720 0.00 ENST00000292574.4
CCDC105
coiled-coil domain containing 105
chr4_+_74445302 0.00 ENST00000502307.1
AREG
amphiregulin
chrX_+_80014746 0.00 ENST00000373296.8
TBX22
T-box transcription factor 22

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.3 2.2 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.2 2.7 GO:0018377 protein myristoylation(GO:0018377)
0.2 1.3 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 0.4 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 1.1 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 0.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 2.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 0.2 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.1 0.9 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.1 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.2 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.5 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.5 GO:0060242 contact inhibition(GO:0060242)
0.0 0.2 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.1 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.0 0.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.5 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005713 recombination nodule(GO:0005713)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 1.3 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.2 2.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.9 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 1.1 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.9 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 2.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels