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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ATF2_ATF1_ATF3
Z-value: 1.87
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Transcription factors associated with ATF2_ATF1_ATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg38_v1_chr1_+_212608628_212608915 | 0.71 | 6.4e-05 | Click! |
| ATF1 | hg38_v1_chr12_+_50764054_50764115 | -0.27 | 2.0e-01 | Click! |
| ATF2 | hg38_v1_chr2_-_175168159_175168213 | 0.21 | 3.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_120914549 Show fit | 12.42 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr1_-_169734064 Show fit | 10.97 |
ENST00000333360.12
|
selectin E |
|
| chr8_+_23528995 Show fit | 9.51 |
ENST00000523930.1
|
solute carrier family 25 member 37 |
|
| chr19_+_45001430 Show fit | 9.09 |
ENST00000625761.2
ENST00000505236.1 ENST00000221452.13 |
RELB proto-oncogene, NF-kB subunit |
|
| chr6_-_29628038 Show fit | 9.03 |
ENST00000355973.7
ENST00000377012.8 |
gamma-aminobutyric acid type B receptor subunit 1 |
|
| chr21_+_42199686 Show fit | 8.66 |
ENST00000398457.6
|
ATP binding cassette subfamily G member 1 |
|
| chr8_+_23528947 Show fit | 7.97 |
ENST00000519973.6
|
solute carrier family 25 member 37 |
|
| chr16_+_50742037 Show fit | 7.57 |
ENST00000569418.5
|
CYLD lysine 63 deubiquitinase |
|
| chr18_+_63887698 Show fit | 7.31 |
ENST00000457692.5
ENST00000299502.9 ENST00000413956.5 |
serpin family B member 2 |
|
| chr6_+_32844789 Show fit | 6.99 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 19.7 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 5.8 | 17.5 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.2 | 16.8 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.1 | 14.7 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.4 | 10.8 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.2 | 10.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 2.5 | 9.8 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 9.5 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 9.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.9 | 8.7 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 13.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 13.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 12.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.4 | 11.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.8 | 10.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 9.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 2.3 | 9.0 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 8.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.7 | 8.0 | GO:0000322 | storage vacuole(GO:0000322) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 27.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 21.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 18.0 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.7 | 13.0 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.4 | 11.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 11.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.9 | 11.0 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.3 | 10.0 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 3.2 | 9.7 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.8 | 9.0 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 36.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 18.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 15.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 14.3 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.2 | 10.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 8.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 7.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 7.1 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.4 | 6.9 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 35.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 17.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 15.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 9.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.4 | 8.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.4 | 8.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 7.9 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.3 | 7.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 7.6 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.3 | 6.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |