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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ATF4

Z-value: 0.72

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.17 ATF4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg38_v1_chr22_+_39520553_395206040.471.8e-02Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_40953463 2.89 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr7_-_116030735 1.64 ENST00000393485.5
TFEC
transcription factor EC
chr7_-_116030750 1.37 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr1_-_149861210 1.18 ENST00000579512.2
H4C15
H4 clustered histone 15
chr10_+_110005804 1.18 ENST00000360162.7
ADD3
adducin 3
chr7_+_30594823 1.08 ENST00000675810.1
ENST00000674815.1
ENST00000454308.6
ENST00000389266.8
ENST00000675693.1
ENST00000675651.1
ENST00000674851.1
GARS1
glycyl-tRNA synthetase 1
chrX_+_9463272 1.07 ENST00000407597.7
ENST00000380961.5
ENST00000424279.6
TBL1X
transducin beta like 1 X-linked
chr1_+_149832647 1.07 ENST00000578186.2
H4C14
H4 clustered histone 14
chr11_-_57324907 1.07 ENST00000358252.8
TNKS1BP1
tankyrase 1 binding protein 1
chr11_-_3057386 1.05 ENST00000529772.5
ENST00000278224.13
ENST00000380525.9
CARS1
cysteinyl-tRNA synthetase 1
chr19_-_46784733 0.97 ENST00000593713.1
ENST00000598022.1
ENST00000434726.6
SLC1A5
solute carrier family 1 member 5
chr6_+_125781108 0.92 ENST00000368357.7
NCOA7
nuclear receptor coactivator 7
chr19_-_46784905 0.92 ENST00000594991.5
SLC1A5
solute carrier family 1 member 5
chr1_-_32817311 0.86 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr14_+_24094053 0.83 ENST00000559250.5
ENST00000560736.5
ENST00000396973.8
ENST00000559837.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr12_-_116881062 0.82 ENST00000550505.5
HRK
harakiri, BCL2 interacting protein
chr14_+_24094301 0.82 ENST00000545054.6
ENST00000561286.5
ENST00000216780.9
ENST00000558096.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr16_+_56932134 0.79 ENST00000439977.7
ENST00000300302.9
ENST00000344114.8
ENST00000379792.6
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr11_+_62881686 0.79 ENST00000536981.6
ENST00000539891.6
SLC3A2
solute carrier family 3 member 2
chr16_+_56936654 0.78 ENST00000563911.5
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr22_+_50481515 0.75 ENST00000395737.2
ENST00000395738.2
ADM2
adrenomedullin 2
chr5_+_68290637 0.67 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr14_+_75428011 0.67 ENST00000651602.1
ENST00000559060.5
JDP2
Jun dimerization protein 2
chr3_+_101849505 0.65 ENST00000326151.9
ENST00000326172.9
NFKBIZ
NFKB inhibitor zeta
chr16_-_67660224 0.65 ENST00000602320.1
ENST00000620761.6
ACD
ACD shelterin complex subunit and telomerase recruitment factor
chr17_-_81937221 0.65 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937277 0.64 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr9_+_78297117 0.62 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr4_-_152536045 0.62 ENST00000603548.6
ENST00000281708.10
FBXW7
F-box and WD repeat domain containing 7
chr17_-_81937320 0.62 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
PYCR1
pyrroline-5-carboxylate reductase 1
chr21_-_43075831 0.59 ENST00000398158.5
ENST00000398165.8
CBS
cystathionine beta-synthase
chr9_+_78297143 0.57 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr12_+_57229694 0.57 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
SHMT2
serine hydroxymethyltransferase 2
chr22_+_35381086 0.56 ENST00000216117.9
ENST00000677931.1
ENST00000679074.1
HMOX1
heme oxygenase 1
chr7_+_99408958 0.56 ENST00000222969.10
BUD31
BUD31 homolog
chr21_-_6467509 0.55 ENST00000624406.3
ENST00000398168.5
ENST00000624934.3
CBSL
cystathionine beta-synthase like
chr9_-_92293674 0.55 ENST00000683679.1
ENST00000683565.1
ENST00000684557.1
ENST00000682578.1
ENST00000443024.7
ENST00000375643.7
ENST00000683469.1
IARS1
isoleucyl-tRNA synthetase 1
chr5_+_144205250 0.53 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr16_-_67660694 0.52 ENST00000219251.13
ENST00000620338.4
ACD
ACD shelterin complex subunit and telomerase recruitment factor
chr12_-_46268989 0.52 ENST00000549049.5
ENST00000439706.5
ENST00000398637.10
SLC38A1
solute carrier family 38 member 1
chr5_+_33440947 0.49 ENST00000455217.6
ENST00000265112.8
TARS1
threonyl-tRNA synthetase 1
chr10_+_49299159 0.48 ENST00000374144.8
C10orf71
chromosome 10 open reading frame 71
chr6_+_159890964 0.47 ENST00000434562.2
ENST00000674077.2
ENSG00000236823.2
MAS1
novel transcript
MAS1 proto-oncogene, G protein-coupled receptor
chr1_+_212608628 0.46 ENST00000613954.4
ENST00000341491.9
ENST00000366985.5
ATF3
activating transcription factor 3
chr2_+_46542474 0.45 ENST00000238738.9
RHOQ
ras homolog family member Q
chr20_+_23362144 0.43 ENST00000338121.10
ENST00000424216.1
GZF1
GDNF inducible zinc finger protein 1
chr5_+_33440696 0.43 ENST00000502553.5
ENST00000514259.5
TARS1
threonyl-tRNA synthetase 1
chr11_-_69704013 0.41 ENST00000294312.4
FGF19
fibroblast growth factor 19
chr7_+_99408609 0.41 ENST00000403633.6
BUD31
BUD31 homolog
chr11_-_128867268 0.41 ENST00000392665.6
ENST00000392666.6
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chr7_-_18027839 0.40 ENST00000506618.5
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1 like 1
chr11_-_128867364 0.40 ENST00000440599.6
ENST00000324036.7
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chrX_+_48539665 0.40 ENST00000376771.9
ENST00000418627.1
TBC1D25
TBC1 domain family member 25
chr3_-_48088824 0.38 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr3_-_48089203 0.38 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr11_-_77474041 0.36 ENST00000278568.8
PAK1
p21 (RAC1) activated kinase 1
chrX_-_15314543 0.35 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr1_-_220046432 0.33 ENST00000609181.5
ENST00000366923.8
EPRS1
glutamyl-prolyl-tRNA synthetase 1
chr12_+_57230336 0.33 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
SHMT2
serine hydroxymethyltransferase 2
chr12_+_57230086 0.32 ENST00000414700.7
ENST00000557703.5
SHMT2
serine hydroxymethyltransferase 2
chr1_+_239719542 0.32 ENST00000448020.1
CHRM3
cholinergic receptor muscarinic 3
chr7_-_138701352 0.32 ENST00000421622.5
ENST00000674285.1
SVOPL
SVOP like
chr12_-_116881431 0.31 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr1_-_206970457 0.30 ENST00000324852.9
ENST00000450945.3
ENST00000400962.8
FCAMR
Fc fragment of IgA and IgM receptor
chr6_+_150865815 0.30 ENST00000367308.8
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr1_-_178871060 0.30 ENST00000234816.7
ANGPTL1
angiopoietin like 1
chr1_-_204411804 0.29 ENST00000367188.5
PPP1R15B
protein phosphatase 1 regulatory subunit 15B
chr1_+_241652275 0.28 ENST00000366552.6
ENST00000437684.7
WDR64
WD repeat domain 64
chr16_+_46884323 0.28 ENST00000340124.9
GPT2
glutamic--pyruvic transaminase 2
chr12_+_57230301 0.28 ENST00000553474.5
SHMT2
serine hydroxymethyltransferase 2
chr1_-_178871022 0.27 ENST00000367629.1
ANGPTL1
angiopoietin like 1
chr12_-_57520480 0.26 ENST00000642841.1
ENST00000547303.5
ENST00000552740.5
ENST00000547526.1
ENST00000346473.8
ENST00000551116.5
ENSG00000285133.1
DDIT3
novel protein
DNA damage inducible transcript 3
chr3_+_148697784 0.25 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chr22_+_41833079 0.23 ENST00000612482.4
ENST00000361204.9
SREBF2
sterol regulatory element binding transcription factor 2
chr10_+_131900999 0.23 ENST00000455566.6
PPP2R2D
protein phosphatase 2 regulatory subunit Bdelta
chr11_-_77474087 0.22 ENST00000356341.8
PAK1
p21 (RAC1) activated kinase 1
chr5_+_154755272 0.21 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr1_+_32817645 0.21 ENST00000526230.1
ENST00000373475.10
ENST00000531256.1
ENST00000482212.1
S100PBP
S100P binding protein
chr19_+_33374312 0.21 ENST00000585933.2
CEBPG
CCAAT enhancer binding protein gamma
chr19_+_11239602 0.20 ENST00000252453.12
ANGPTL8
angiopoietin like 8
chr17_-_42676980 0.20 ENST00000587627.1
ENST00000591022.6
ENST00000293349.10
PLEKHH3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr17_-_48626325 0.19 ENST00000311177.7
HOXB9
homeobox B9
chr16_-_70289480 0.19 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr3_-_3109980 0.18 ENST00000256452.7
ENST00000311981.12
ENST00000430514.6
ENST00000456302.5
IL5RA
interleukin 5 receptor subunit alpha
chr1_-_167914089 0.18 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr12_+_49741802 0.18 ENST00000423828.5
ENST00000550445.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr16_-_705726 0.17 ENST00000397621.6
ENST00000324361.9
FBXL16
F-box and leucine rich repeat protein 16
chr19_+_1450113 0.13 ENST00000590469.6
ENST00000590877.5
ENST00000233607.6
APC2
APC regulator of WNT signaling pathway 2
chr15_+_40594001 0.13 ENST00000346991.9
ENST00000528975.5
KNL1
kinetochore scaffold 1
chr17_-_79839387 0.13 ENST00000448310.1
ENST00000269397.9
CBX4
chromobox 4
chr8_-_38150943 0.13 ENST00000276449.9
STAR
steroidogenic acute regulatory protein
chrX_+_24054931 0.12 ENST00000253039.9
ENST00000423068.1
EIF2S3
eukaryotic translation initiation factor 2 subunit gamma
chr17_+_41689862 0.11 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr9_+_36169382 0.11 ENST00000335119.4
CCIN
calicin
chr5_-_146182591 0.11 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
LARS1
leucyl-tRNA synthetase 1
chr2_-_240820945 0.11 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr10_-_95656643 0.11 ENST00000371221.3
ENST00000371224.7
ALDH18A1
aldehyde dehydrogenase 18 family member A1
chr15_+_40594241 0.10 ENST00000532056.5
ENST00000527044.5
ENST00000399668.7
KNL1
kinetochore scaffold 1
chr22_-_29061831 0.10 ENST00000216071.5
C22orf31
chromosome 22 open reading frame 31
chr5_-_146182475 0.10 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
LARS1
leucyl-tRNA synthetase 1
chr3_-_33645433 0.09 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr4_+_94207845 0.09 ENST00000457823.6
ENST00000354268.9
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr11_+_119085200 0.09 ENST00000650101.1
HMBS
hydroxymethylbilane synthase
chr4_+_94207596 0.09 ENST00000359052.8
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_3110347 0.08 ENST00000383846.5
ENST00000427088.1
ENST00000446632.7
ENST00000418488.6
ENST00000438560.5
IL5RA
interleukin 5 receptor subunit alpha
chr19_+_33373694 0.07 ENST00000284000.9
CEBPG
CCAAT enhancer binding protein gamma
chr9_+_97983332 0.07 ENST00000339399.5
ANP32B
acidic nuclear phosphoprotein 32 family member B
chr1_+_32817442 0.07 ENST00000373476.5
ENST00000529027.5
S100PBP
S100P binding protein
chr7_-_56034133 0.07 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr10_+_94089034 0.05 ENST00000676102.1
ENST00000371385.8
PLCE1
phospholipase C epsilon 1
chr11_+_119084873 0.05 ENST00000652429.1
ENST00000442944.7
ENST00000537841.5
ENST00000542729.5
ENST00000546302.6
ENST00000536813.6
ENST00000544387.5
ENST00000543090.5
HMBS
hydroxymethylbilane synthase
chr5_+_44808930 0.03 ENST00000507110.6
MRPS30
mitochondrial ribosomal protein S30
chr7_-_48029102 0.02 ENST00000297325.9
ENST00000412142.5
ENST00000395572.6
SUN3
Sad1 and UNC84 domain containing 3
chr12_-_49903853 0.00 ENST00000320634.8
FAIM2
Fas apoptotic inhibitory molecule 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.4 1.2 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.3 1.2 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.3 2.0 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 1.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 1.1 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.2 0.6 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.2 1.6 GO:0006116 NADH oxidation(GO:0006116)
0.2 0.6 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 2.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.8 GO:0060356 leucine import(GO:0060356)
0.1 1.0 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.3 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 1.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.6 GO:0061052 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 0.3 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.3 GO:0042851 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0018963 phthalate metabolic process(GO:0018963) positive regulation of bile acid biosynthetic process(GO:0070859) cellular response to luteinizing hormone stimulus(GO:0071373) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.4 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 1.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.5 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.7 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.3 GO:1903912 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.2 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.4 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 1.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.7 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 3.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.5 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.8 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.1 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 1.6 GO:1990037 Lewy body core(GO:1990037)
0.2 0.7 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.5 GO:0070552 BRISC complex(GO:0070552)
0.1 1.2 GO:0070187 telosome(GO:0070187)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.6 GO:0071437 invadopodium(GO:0071437)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 2.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 1.6 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 1.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 1.5 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 1.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 1.1 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 0.4 GO:0032427 GBD domain binding(GO:0032427)
0.1 1.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.6 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.7 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.1 0.3 GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.1 0.3 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.2 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 1.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 3.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 1.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 3.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 1.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis