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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for BACH1_NFE2_NFE2L2
Z-value: 1.16
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Transcription factors associated with BACH1_NFE2_NFE2L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH1 | hg38_v1_chr21_+_29298890_29298932, hg38_v1_chr21_+_29299368_29299441 | -0.50 | 1.1e-02 | Click! |
| NFE2L2 | hg38_v1_chr2_-_177392673_177392704 | -0.41 | 4.0e-02 | Click! |
| NFE2 | hg38_v1_chr12_-_54295748_54295798, hg38_v1_chr12_-_54297884_54297941, hg38_v1_chr12_-_54300974_54301021 | -0.16 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.6 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.1 | 8.9 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 6.0 | GO:0032259 | methylation(GO:0032259) |
| 0.0 | 5.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.3 | 4.1 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.2 | 3.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.2 | 3.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.3 | 3.4 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.1 | 3.2 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.2 | 2.8 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.5 | 6.8 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 4.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 3.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.4 | 2.8 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.0 | 2.7 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 2.4 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 2.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 2.1 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.2 | 1.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.4 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 7.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 6.8 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 5.6 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.1 | 3.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 3.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 3.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 2.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.4 | 2.2 | GO:0004473 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.2 | 2.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 3.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.6 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 5.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 3.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 2.7 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 2.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 1.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 1.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |