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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for BARHL1
Z-value: 1.64
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Transcription factors associated with BARHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL1 | hg38_v1_chr9_+_132582581_132582617 | -0.48 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 13.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.3 | 13.2 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 8.9 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 1.2 | 8.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.5 | 7.4 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.3 | 6.7 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.9 | 5.6 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.4 | 4.9 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 4.9 | GO:0070914 | UV-damage excision repair(GO:0070914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 9.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 9.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 7.8 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.1 | 7.6 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 7.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 7.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 7.0 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 6.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 6.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 8.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 7.2 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.4 | 6.9 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 6.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.9 | 5.6 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 4.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.5 | 4.4 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.2 | 4.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 4.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 7.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 7.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 6.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 6.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 5.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 3.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 3.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 7.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 7.1 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 6.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 6.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 6.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 5.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.2 | 5.1 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.1 | 4.7 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.3 | 4.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |