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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for BBX

Z-value: 0.43

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.19 BBX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg38_v1_chr3_+_107522936_1075230030.359.0e-02Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_185775271 0.71 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr4_-_185775890 0.68 ENST00000437304.6
SORBS2
sorbin and SH3 domain containing 2
chr1_+_158461574 0.61 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
OR10K1
olfactory receptor family 10 subfamily K member 1
chr4_-_185812209 0.54 ENST00000393523.6
ENST00000393528.7
ENST00000449407.6
SORBS2
sorbin and SH3 domain containing 2
chr1_-_686673 0.51 ENST00000332831.4
OR4F16
olfactory receptor family 4 subfamily F member 16
chr6_+_117482634 0.38 ENST00000296955.12
ENST00000338728.10
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr8_-_28490220 0.34 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
FBXO16
F-box protein 16
chr5_+_181367268 0.34 ENST00000456475.1
OR4F3
olfactory receptor family 4 subfamily F member 3
chr11_+_58622659 0.30 ENST00000361987.6
CNTF
ciliary neurotrophic factor
chr3_-_169147734 0.27 ENST00000464456.5
MECOM
MDS1 and EVI1 complex locus
chr5_+_141135199 0.26 ENST00000231134.8
ENST00000623915.1
PCDHB5
protocadherin beta 5
chr3_-_185821092 0.26 ENST00000421047.3
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chr9_-_5833014 0.25 ENST00000339450.10
ERMP1
endoplasmic reticulum metallopeptidase 1
chr3_+_98147479 0.23 ENST00000641380.1
OR5H14
olfactory receptor family 5 subfamily H member 14
chr2_-_110473041 0.22 ENST00000632897.1
ENST00000413601.3
LIMS4
LIM zinc finger domain containing 4
chr14_-_80959484 0.21 ENST00000555529.5
ENST00000556042.5
ENST00000556981.5
CEP128
centrosomal protein 128
chr3_+_51817596 0.20 ENST00000456080.5
ENSG00000285749.2
novel protein
chr9_-_90642855 0.19 ENST00000637905.1
DIRAS2
DIRAS family GTPase 2
chr20_-_31722854 0.18 ENST00000307677.5
BCL2L1
BCL2 like 1
chr2_+_209653171 0.18 ENST00000447185.5
MAP2
microtubule associated protein 2
chr1_-_58577244 0.18 ENST00000371225.4
TACSTD2
tumor associated calcium signal transducer 2
chr20_-_31722533 0.17 ENST00000677194.1
ENST00000434194.2
ENST00000376062.6
BCL2L1
BCL2 like 1
chr6_+_72212802 0.17 ENST00000401910.7
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_121437378 0.17 ENST00000650427.1
ENST00000647564.1
GJA1
gap junction protein alpha 1
chr14_+_74763308 0.17 ENST00000325680.12
ENST00000552421.5
YLPM1
YLP motif containing 1
chr4_-_158159657 0.17 ENST00000590648.5
GASK1B
golgi associated kinase 1B
chr6_+_72212887 0.16 ENST00000523963.5
RIMS1
regulating synaptic membrane exocytosis 1
chr9_-_13175824 0.15 ENST00000545857.5
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr14_+_22766522 0.15 ENST00000285848.9
ENST00000612549.6
ENST00000431881.6
ENST00000412791.5
ENST00000358043.5
OXA1L
OXA1L mitochondrial inner membrane protein
chr20_-_31722949 0.15 ENST00000376055.9
BCL2L1
BCL2 like 1
chr9_+_35161951 0.13 ENST00000617908.4
ENST00000619578.4
UNC13B
unc-13 homolog B
chr21_-_30492008 0.13 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr18_+_32190033 0.13 ENST00000269202.11
MEP1B
meprin A subunit beta
chr6_-_135497230 0.13 ENST00000681365.1
AHI1
Abelson helper integration site 1
chr18_+_32190015 0.13 ENST00000581447.1
MEP1B
meprin A subunit beta
chr6_+_31927486 0.13 ENST00000442278.6
C2
complement C2
chr17_+_42798881 0.13 ENST00000588527.5
CNTD1
cyclin N-terminal domain containing 1
chr6_+_24356903 0.13 ENST00000274766.2
KAAG1
kidney associated antigen 1
chr17_+_42798857 0.13 ENST00000588408.6
CNTD1
cyclin N-terminal domain containing 1
chr3_-_58666765 0.12 ENST00000358781.7
FAM3D
FAM3 metabolism regulating signaling molecule D
chr12_-_100262356 0.12 ENST00000548313.5
DEPDC4
DEP domain containing 4
chr10_+_102655101 0.12 ENST00000644914.1
ENST00000642304.1
TRIM8
tripartite motif containing 8
chr20_-_57711536 0.11 ENST00000265626.8
PMEPA1
prostate transmembrane protein, androgen induced 1
chr9_-_90642791 0.11 ENST00000375765.5
ENST00000636786.1
DIRAS2
DIRAS family GTPase 2
chr4_+_158315309 0.10 ENST00000460056.6
RXFP1
relaxin family peptide receptor 1
chr1_-_225428813 0.10 ENST00000338179.6
ENST00000425080.1
LBR
lamin B receptor
chr3_-_146528750 0.10 ENST00000483300.5
PLSCR1
phospholipid scramblase 1
chr2_+_200440649 0.10 ENST00000366118.2
SPATS2L
spermatogenesis associated serine rich 2 like
chr14_+_21868822 0.10 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr5_-_56116946 0.09 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr1_-_216805367 0.09 ENST00000360012.7
ESRRG
estrogen related receptor gamma
chr15_+_40351026 0.09 ENST00000448599.2
PHGR1
proline, histidine and glycine rich 1
chr6_-_25874212 0.09 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr14_+_22304051 0.09 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr3_+_151814102 0.09 ENST00000232892.12
AADAC
arylacetamide deacetylase
chr9_+_35162000 0.09 ENST00000396787.5
ENST00000378495.7
ENST00000635942.1
ENST00000378496.8
UNC13B
unc-13 homolog B
chr14_+_20110739 0.09 ENST00000641386.2
ENST00000641633.2
OR4K17
olfactory receptor family 4 subfamily K member 17
chr16_+_56191476 0.09 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr16_+_28751787 0.09 ENST00000357796.7
ENST00000550983.1
NPIPB9
nuclear pore complex interacting protein family member B9
chr19_+_6887560 0.08 ENST00000250572.12
ENST00000381407.9
ENST00000450315.7
ENST00000312053.9
ENST00000381404.8
ADGRE1
adhesion G protein-coupled receptor E1
chr2_+_33436304 0.08 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr1_+_51617079 0.08 ENST00000447887.5
ENST00000428468.6
ENST00000453295.5
OSBPL9
oxysterol binding protein like 9
chr9_+_101185029 0.08 ENST00000395056.2
PLPPR1
phospholipid phosphatase related 1
chr3_+_148865288 0.08 ENST00000296046.4
CPA3
carboxypeptidase A3
chr19_+_7763210 0.07 ENST00000359059.10
ENST00000596363.5
ENST00000394122.7
ENST00000327325.10
CLEC4M
C-type lectin domain family 4 member M
chrX_-_126166273 0.07 ENST00000360028.4
DCAF12L2
DDB1 and CUL4 associated factor 12 like 2
chr4_-_993376 0.07 ENST00000398520.6
ENST00000398516.3
SLC26A1
solute carrier family 26 member 1
chr8_-_6926066 0.06 ENST00000297436.3
DEFA6
defensin alpha 6
chr15_-_74203172 0.06 ENST00000616000.4
STRA6
signaling receptor and transporter of retinol STRA6
chr12_+_55362975 0.06 ENST00000641576.1
OR6C75
olfactory receptor family 6 subfamily C member 75
chr7_-_87059639 0.06 ENST00000450689.7
ELAPOR2
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr8_-_144605699 0.05 ENST00000377307.6
ENST00000276826.5
ARHGAP39
Rho GTPase activating protein 39
chr21_+_30396030 0.05 ENST00000355459.4
KRTAP13-1
keratin associated protein 13-1
chrX_-_141698739 0.05 ENST00000370515.3
SPANXD
SPANX family member D
chrX_-_19799751 0.05 ENST00000379698.8
SH3KBP1
SH3 domain containing kinase binding protein 1
chr4_-_112636858 0.05 ENST00000503172.5
ENST00000505019.6
ENST00000309071.9
ZGRF1
zinc finger GRF-type containing 1
chr17_+_68259164 0.05 ENST00000448504.6
ARSG
arylsulfatase G
chr10_-_13972355 0.05 ENST00000264546.10
FRMD4A
FERM domain containing 4A
chr17_+_29941605 0.05 ENST00000394835.7
EFCAB5
EF-hand calcium binding domain 5
chr5_+_162067500 0.05 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr7_+_117480052 0.05 ENST00000426809.5
ENST00000649781.1
CFTR
CF transmembrane conductance regulator
chr5_-_149550284 0.04 ENST00000504676.5
ENST00000515435.5
CSNK1A1
casein kinase 1 alpha 1
chr4_-_993430 0.04 ENST00000361661.6
ENST00000622731.4
SLC26A1
solute carrier family 26 member 1
chr11_+_56176618 0.04 ENST00000312298.1
OR5J2
olfactory receptor family 5 subfamily J member 2
chr5_+_162067458 0.04 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr7_+_32979445 0.04 ENST00000418354.5
ENST00000490776.3
FKBP9
FKBP prolyl isomerase 9
chr5_-_176034680 0.04 ENST00000514861.5
THOC3
THO complex 3
chr1_+_152811971 0.04 ENST00000360090.4
LCE1B
late cornified envelope 1B
chr4_+_68447453 0.04 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr17_-_17281232 0.04 ENST00000417352.5
ENST00000268717.10
COPS3
COP9 signalosome subunit 3
chr20_-_46684467 0.03 ENST00000372121.5
SLC13A3
solute carrier family 13 member 3
chr1_+_95151377 0.03 ENST00000604203.1
TLCD4-RWDD3
TLCD4-RWDD3 readthrough
chr21_+_18244828 0.03 ENST00000299295.7
CHODL
chondrolectin
chr6_-_130222813 0.03 ENST00000437477.6
ENST00000439090.7
SAMD3
sterile alpha motif domain containing 3
chr12_-_99984227 0.03 ENST00000547776.6
ENST00000547010.5
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_16881967 0.03 ENST00000402239.7
ENST00000310398.7
ENST00000414935.1
AGR3
anterior gradient 3, protein disulphide isomerase family member
chr14_+_63761836 0.03 ENST00000674003.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr19_+_9250930 0.03 ENST00000456448.3
OR7E24
olfactory receptor family 7 subfamily E member 24
chr16_-_28363508 0.02 ENST00000532254.1
NPIPB6
nuclear pore complex interacting protein family member B6
chr4_-_103099811 0.02 ENST00000504285.5
ENST00000296424.9
BDH2
3-hydroxybutyrate dehydrogenase 2
chr15_-_75455767 0.02 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr22_+_29438583 0.02 ENST00000354373.2
RFPL1
ret finger protein like 1
chrX_+_55623400 0.02 ENST00000339140.5
FOXR2
forkhead box R2
chr13_+_76948500 0.02 ENST00000377462.6
ACOD1
aconitate decarboxylase 1
chr12_+_18262730 0.02 ENST00000675017.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr2_-_55010348 0.01 ENST00000394609.6
RTN4
reticulon 4
chr18_-_13915531 0.01 ENST00000327606.4
MC2R
melanocortin 2 receptor
chrX_+_11293411 0.01 ENST00000348912.4
ENST00000380714.7
ENST00000380712.7
AMELX
amelogenin X-linked
chr5_+_150661243 0.01 ENST00000517768.6
MYOZ3
myozenin 3
chrX_+_54807599 0.01 ENST00000375053.6
ENST00000627068.2
ENST00000375068.6
ENST00000347546.8
MAGED2
MAGE family member D2
chr4_+_70592253 0.01 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr1_+_192575765 0.01 ENST00000469578.2
ENST00000367459.8
RGS1
regulator of G protein signaling 1
chr19_-_14848922 0.01 ENST00000641129.1
OR7A10
olfactory receptor family 7 subfamily A member 10
chr1_-_153150884 0.00 ENST00000368748.5
SPRR2G
small proline rich protein 2G
chr1_+_117420597 0.00 ENST00000449370.6
MAN1A2
mannosidase alpha class 1A member 2
chr6_+_52420107 0.00 ENST00000636489.1
ENST00000637089.1
ENST00000637353.1
ENST00000637263.1
EFHC1
EF-hand domain containing 1
chr2_-_61854119 0.00 ENST00000405894.3
FAM161A
FAM161 centrosomal protein A
chr22_+_32475235 0.00 ENST00000452138.3
FBXO7
F-box protein 7
chr4_-_67701113 0.00 ENST00000420827.2
ENST00000322244.10
UBA6
ubiquitin like modifier activating enzyme 6
chr5_-_22853320 0.00 ENST00000504376.6
ENST00000382254.6
CDH12
cadherin 12
chr2_-_61854013 0.00 ENST00000404929.6
FAM161A
FAM161 centrosomal protein A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 0.5 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.3 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 1.9 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0039023 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.0 0.2 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0 0.2 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0046968 peptide antigen transport(GO:0046968)
0.0 0.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.0 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.2 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.0 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway