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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.31

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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol Gene ID Gene Info
BHLHE22
ENSG00000180828.3 BHLHE22
BHLHA15
ENSG00000180535.4 BHLHA15
BHLHE23
ENSG00000125533.6 BHLHE23

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE22hg38_v1_chr8_+_64580357_645803740.377.1e-02Click!
BHLHA15hg38_v1_chr7_+_98211431_98211474-0.367.4e-02Click!
BHLHE23hg38_v1_chr20_-_63006961_63007035-0.029.2e-01Click!

Activity profile of BHLHE22_BHLHA15_BHLHE23 motif

Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_22207502 0.32 ENST00000390461.2
TRAV34
T cell receptor alpha variable 34
chr16_-_69351778 0.28 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr19_+_55857437 0.26 ENST00000587891.5
NLRP4
NLR family pyrin domain containing 4
chr19_-_11339573 0.25 ENST00000222120.8
RAB3D
RAB3D, member RAS oncogene family
chr7_-_27165517 0.24 ENST00000396345.1
ENST00000343483.7
HOXA9
homeobox A9
chr1_+_244051275 0.24 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr3_-_121660892 0.23 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_+_5094405 0.22 ENST00000380554.5
AKR1C3
aldo-keto reductase family 1 member C3
chr5_-_111976925 0.22 ENST00000395634.7
NREP
neuronal regeneration related protein
chr5_-_59430600 0.21 ENST00000636120.1
PDE4D
phosphodiesterase 4D
chr14_-_106875069 0.17 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr15_-_65211463 0.17 ENST00000261883.6
CILP
cartilage intermediate layer protein
chr5_+_175872741 0.16 ENST00000502265.5
CPLX2
complexin 2
chr7_+_148590760 0.14 ENST00000307003.3
C7orf33
chromosome 7 open reading frame 33
chr3_-_18438767 0.13 ENST00000454909.6
SATB1
SATB homeobox 1
chr8_+_21966215 0.12 ENST00000433566.8
XPO7
exportin 7
chr9_+_18474165 0.12 ENST00000380566.8
ADAMTSL1
ADAMTS like 1
chr12_-_102478539 0.12 ENST00000424202.6
IGF1
insulin like growth factor 1
chr15_+_65550819 0.12 ENST00000569894.5
HACD3
3-hydroxyacyl-CoA dehydratase 3
chr1_+_60865259 0.12 ENST00000371191.5
NFIA
nuclear factor I A
chr7_+_116862552 0.12 ENST00000361183.8
ENST00000639546.1
ENST00000490693.5
CAPZA2
capping actin protein of muscle Z-line subunit alpha 2
chr11_+_65638085 0.12 ENST00000534313.6
ENST00000533361.1
ENST00000526137.1
SIPA1
signal-induced proliferation-associated 1
chr3_-_126357399 0.12 ENST00000296233.4
KLF15
Kruppel like factor 15
chr15_-_55408018 0.11 ENST00000569205.5
CCPG1
cell cycle progression 1
chr4_+_159267737 0.11 ENST00000264431.8
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr15_+_40358207 0.11 ENST00000267889.5
DISP2
dispatched RND transporter family member 2
chr14_-_76826229 0.11 ENST00000557497.1
ANGEL1
angel homolog 1
chr14_+_76826372 0.10 ENST00000393774.7
ENST00000555189.1
LRRC74A
leucine rich repeat containing 74A
chr6_+_162727129 0.10 ENST00000337019.7
ENST00000366889.6
PACRG
parkin coregulated
chr19_-_54364983 0.10 ENST00000434277.6
LAIR1
leukocyte associated immunoglobulin like receptor 1
chr12_+_64610458 0.09 ENST00000542104.6
RASSF3
Ras association domain family member 3
chr5_+_136160986 0.09 ENST00000507637.1
SMAD5
SMAD family member 5
chr2_-_187513641 0.08 ENST00000392365.5
ENST00000435414.5
TFPI
tissue factor pathway inhibitor
chr8_-_38382146 0.08 ENST00000534155.1
ENST00000433384.6
ENST00000317025.13
ENST00000316985.7
NSD3
nuclear receptor binding SET domain protein 3
chrX_-_15384402 0.08 ENST00000297904.4
VEGFD
vascular endothelial growth factor D
chr5_-_138338325 0.08 ENST00000510119.1
ENST00000513970.5
CDC25C
cell division cycle 25C
chr7_-_41703062 0.08 ENST00000242208.5
INHBA
inhibin subunit beta A
chr17_-_49209367 0.07 ENST00000300406.6
ENST00000511277.5
ENST00000511673.1
GNGT2
G protein subunit gamma transducin 2
chr5_-_170297746 0.07 ENST00000046794.10
LCP2
lymphocyte cytosolic protein 2
chr3_-_197573323 0.07 ENST00000358186.6
ENST00000431056.5
BDH1
3-hydroxybutyrate dehydrogenase 1
chr1_-_152159227 0.07 ENST00000316073.3
RPTN
repetin
chr8_-_134510182 0.07 ENST00000521673.5
ZFAT
zinc finger and AT-hook domain containing
chr2_-_153478753 0.07 ENST00000325926.4
RPRM
reprimo, TP53 dependent G2 arrest mediator homolog
chr19_+_18097763 0.07 ENST00000262811.10
MAST3
microtubule associated serine/threonine kinase 3
chr3_+_46883337 0.07 ENST00000313049.9
PTH1R
parathyroid hormone 1 receptor
chr17_+_7308339 0.06 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr4_-_140154176 0.06 ENST00000509479.6
MAML3
mastermind like transcriptional coactivator 3
chr17_+_7307961 0.06 ENST00000419711.6
ENST00000571955.5
ENST00000573714.5
EIF5A
eukaryotic translation initiation factor 5A
chr12_-_14938508 0.06 ENST00000266397.7
ERP27
endoplasmic reticulum protein 27
chr14_-_106025628 0.06 ENST00000631943.1
IGHV7-4-1
immunoglobulin heavy variable 7-4-1
chr6_+_54083423 0.06 ENST00000460844.6
ENST00000370876.6
MLIP
muscular LMNA interacting protein
chr3_-_179266971 0.06 ENST00000349697.2
ENST00000497599.5
KCNMB3
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr9_+_2158487 0.05 ENST00000634706.1
ENST00000634338.1
ENST00000635688.1
ENST00000634435.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr9_+_2158239 0.05 ENST00000635133.1
ENST00000634931.1
ENST00000423555.6
ENST00000382185.6
ENST00000302401.8
ENST00000382183.6
ENST00000417599.6
ENST00000382186.6
ENST00000635530.1
ENST00000635388.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_182522703 0.05 ENST00000410103.1
PDE1A
phosphodiesterase 1A
chr3_-_197184131 0.05 ENST00000452595.5
DLG1
discs large MAGUK scaffold protein 1
chr3_-_197183849 0.05 ENST00000443183.5
DLG1
discs large MAGUK scaffold protein 1
chr15_-_48963912 0.05 ENST00000332408.9
SHC4
SHC adaptor protein 4
chr3_-_43105939 0.05 ENST00000441964.1
POMGNT2
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
chrX_+_70290077 0.05 ENST00000374403.4
KIF4A
kinesin family member 4A
chr1_+_248508073 0.05 ENST00000641804.1
OR2G6
olfactory receptor family 2 subfamily G member 6
chr20_-_35529618 0.05 ENST00000246199.5
ENST00000424444.1
ENST00000374345.8
ENST00000444723.3
C20orf173
chromosome 20 open reading frame 173
chr2_-_162243375 0.05 ENST00000188790.9
ENST00000443424.5
FAP
fibroblast activation protein alpha
chr9_+_18474100 0.04 ENST00000327883.11
ENST00000431052.6
ENST00000380570.8
ENST00000380548.9
ADAMTSL1
ADAMTS like 1
chr3_+_113211459 0.04 ENST00000495514.5
BOC
BOC cell adhesion associated, oncogene regulated
chr3_-_197183806 0.04 ENST00000671246.1
ENST00000660553.1
DLG1
discs large MAGUK scaffold protein 1
chr3_+_98149326 0.04 ENST00000437310.1
OR5H14
olfactory receptor family 5 subfamily H member 14
chr1_+_170663917 0.04 ENST00000497230.2
PRRX1
paired related homeobox 1
chr3_-_108953762 0.04 ENST00000393963.7
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr3_-_197183963 0.04 ENST00000653795.1
DLG1
discs large MAGUK scaffold protein 1
chr2_+_233729042 0.04 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr7_-_93226449 0.04 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr1_-_205121986 0.03 ENST00000367164.1
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit
chr3_-_108953870 0.03 ENST00000261047.8
GUCA1C
guanylate cyclase activator 1C
chr4_+_113292838 0.03 ENST00000672411.1
ENST00000673231.1
ANK2
ankyrin 2
chr15_-_63156774 0.03 ENST00000462430.5
RPS27L
ribosomal protein S27 like
chr6_+_96562548 0.03 ENST00000541107.5
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr4_+_113292925 0.03 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ANK2
ankyrin 2
chr12_-_30735014 0.03 ENST00000433722.6
CAPRIN2
caprin family member 2
chr3_-_50350710 0.03 ENST00000232501.8
NPRL2
NPR2 like, GATOR1 complex subunit
chr3_-_53130405 0.03 ENST00000467048.1
ENST00000296292.8
ENST00000394738.7
RFT1
RFT1 homolog
chr12_+_50400809 0.03 ENST00000293618.12
ENST00000429001.7
ENST00000398473.7
ENST00000548174.5
ENST00000548697.5
ENST00000548993.5
ENST00000614335.4
ENST00000522085.5
ENST00000615080.4
ENST00000518444.5
ENST00000551886.5
ENST00000523389.5
ENST00000518561.5
ENST00000347328.9
ENST00000550260.1
LARP4
La ribonucleoprotein 4
chr17_-_39607876 0.03 ENST00000302584.5
NEUROD2
neuronal differentiation 2
chr3_+_113532508 0.03 ENST00000264852.9
SIDT1
SID1 transmembrane family member 1
chr11_+_66241227 0.03 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr8_+_66870749 0.02 ENST00000396592.7
ENST00000422365.7
ENST00000492775.5
MCMDC2
minichromosome maintenance domain containing 2
chr5_+_157180816 0.02 ENST00000422843.8
ITK
IL2 inducible T cell kinase
chr1_+_159302321 0.02 ENST00000368114.1
FCER1A
Fc fragment of IgE receptor Ia
chr1_+_46303646 0.02 ENST00000311672.10
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr5_+_138338256 0.02 ENST00000513056.5
ENST00000239906.10
ENST00000511276.1
FAM53C
family with sequence similarity 53 member C
chr4_-_73223082 0.02 ENST00000509867.6
ANKRD17
ankyrin repeat domain 17
chr2_-_182522556 0.02 ENST00000435564.5
PDE1A
phosphodiesterase 1A
chr4_-_158173042 0.02 ENST00000592057.1
ENST00000393807.9
GASK1B
golgi associated kinase 1B
chr9_+_68356603 0.02 ENST00000396396.6
PGM5
phosphoglucomutase 5
chrX_-_130268883 0.02 ENST00000447817.1
ENST00000370978.9
ZNF280C
zinc finger protein 280C
chr16_+_21704963 0.02 ENST00000388957.3
OTOA
otoancorin
chr11_+_94768331 0.02 ENST00000317829.12
ENST00000433060.3
AMOTL1
angiomotin like 1
chr5_-_115296610 0.02 ENST00000379611.10
ENST00000506442.5
CCDC112
coiled-coil domain containing 112
chr10_-_67838019 0.02 ENST00000483798.6
DNAJC12
DnaJ heat shock protein family (Hsp40) member C12
chr4_+_2812259 0.02 ENST00000502260.5
ENST00000435136.8
SH3BP2
SH3 domain binding protein 2
chr1_-_217076889 0.02 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr10_+_18340821 0.02 ENST00000612743.1
ENST00000612134.4
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr15_+_84600986 0.01 ENST00000540936.1
ENST00000448803.6
ENST00000546275.1
ENST00000546148.6
ENST00000442073.3
ENST00000334141.7
ENST00000358472.3
ENST00000502939.2
ENST00000379358.7
ENST00000327179.6
ZSCAN2
zinc finger and SCAN domain containing 2
chr14_+_69398683 0.01 ENST00000556605.5
ENST00000031146.8
ENST00000336643.10
SLC39A9
solute carrier family 39 member 9
chr7_-_113118544 0.01 ENST00000397764.8
ENST00000441359.1
SMIM30
small integral membrane protein 30
chr10_-_15860450 0.01 ENST00000277632.8
MINDY3
MINDY lysine 48 deubiquitinase 3
chr2_+_161624335 0.01 ENST00000375514.9
ENST00000415876.6
SLC4A10
solute carrier family 4 member 10
chr3_+_113211539 0.01 ENST00000682979.1
ENST00000485230.5
BOC
BOC cell adhesion associated, oncogene regulated
chr10_+_18340699 0.01 ENST00000377329.10
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr5_-_172006567 0.01 ENST00000517395.6
ENST00000265094.9
ENST00000393802.6
FBXW11
F-box and WD repeat domain containing 11
chr2_+_161624406 0.01 ENST00000446997.6
ENST00000272716.9
SLC4A10
solute carrier family 4 member 10
chr15_+_57219411 0.01 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
TCF12
transcription factor 12
chr14_-_50830641 0.01 ENST00000453196.6
ENST00000496749.1
NIN
ninein
chr4_-_158173004 0.01 ENST00000585682.6
GASK1B
golgi associated kinase 1B
chr20_+_43565115 0.01 ENST00000423407.7
SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_98168700 0.01 ENST00000383696.4
OR5H15
olfactory receptor family 5 subfamily H member 15
chr2_-_32265732 0.01 ENST00000360906.9
ENST00000342905.10
NLRC4
NLR family CARD domain containing 4
chr8_+_67064316 0.01 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
CSPP1
centrosome and spindle pole associated protein 1
chr14_-_50831046 0.01 ENST00000476352.5
ENST00000324330.13
ENST00000382041.7
ENST00000453401.6
ENST00000530997.7
NIN
ninein
chr5_-_172006817 0.01 ENST00000296933.10
FBXW11
F-box and WD repeat domain containing 11
chr7_+_107891135 0.01 ENST00000639772.1
ENST00000440410.5
ENST00000437604.6
ENST00000205402.10
DLD
dihydrolipoamide dehydrogenase
chr3_+_137998735 0.01 ENST00000343735.8
CLDN18
claudin 18
chr3_-_33659441 0.01 ENST00000650653.1
ENST00000480013.6
CLASP2
cytoplasmic linker associated protein 2
chrX_+_108091752 0.01 ENST00000457035.5
ENST00000372232.8
ATG4A
autophagy related 4A cysteine peptidase
chr6_+_72366730 0.01 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chrX_+_108091665 0.00 ENST00000345734.7
ATG4A
autophagy related 4A cysteine peptidase
chr3_-_33659097 0.00 ENST00000461133.8
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr10_-_102418748 0.00 ENST00000020673.6
PSD
pleckstrin and Sec7 domain containing
chr14_-_50830479 0.00 ENST00000382043.8
NIN
ninein
chr14_-_69398276 0.00 ENST00000557016.6
ENST00000555373.1
ERH
ERH mRNA splicing and mitosis factor
chr11_-_62591500 0.00 ENST00000476907.6
ENST00000278279.7
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chr11_-_62591554 0.00 ENST00000494385.1
ENST00000308436.11
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
chrX_+_108044967 0.00 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr10_+_134465 0.00 ENST00000439456.5
ENST00000397962.8
ENST00000309776.8
ENST00000397959.7
ZMYND11
zinc finger MYND-type containing 11
chr10_-_77090722 0.00 ENST00000638531.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr10_-_30999469 0.00 ENST00000538351.6
ZNF438
zinc finger protein 438

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.2 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.1 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.1 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.0 GO:0097325 melanocyte proliferation(GO:0097325)
0.0 0.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045550 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.1 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.0 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)