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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for BHLHE40

Z-value: 0.67

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.5 BHLHE40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg38_v1_chr3_+_4979428_49794950.144.9e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_5977589 3.78 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
IL15RA
interleukin 15 receptor subunit alpha
chr10_-_5977535 3.62 ENST00000379977.8
IL15RA
interleukin 15 receptor subunit alpha
chr4_-_176792913 2.24 ENST00000618562.2
VEGFC
vascular endothelial growth factor C
chr22_+_41301514 2.17 ENST00000352645.5
ZC3H7B
zinc finger CCCH-type containing 7B
chr1_+_218346235 2.09 ENST00000366929.4
TGFB2
transforming growth factor beta 2
chr10_-_5977492 2.07 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
IL15RA
interleukin 15 receptor subunit alpha
chr8_+_32548303 1.97 ENST00000650967.1
NRG1
neuregulin 1
chr8_+_32548210 1.77 ENST00000523079.5
ENST00000650919.1
NRG1
neuregulin 1
chr16_-_56668034 1.69 ENST00000569500.5
ENST00000379811.4
ENST00000444837.6
MT1G
metallothionein 1G
chr12_-_121296669 1.67 ENST00000652382.1
CAMKK2
calcium/calmodulin dependent protein kinase kinase 2
chr12_-_121296685 1.57 ENST00000412367.6
ENST00000404169.8
ENST00000402834.8
CAMKK2
calcium/calmodulin dependent protein kinase kinase 2
chr2_-_135985568 1.41 ENST00000264161.9
DARS1
aspartyl-tRNA synthetase 1
chr2_-_10448318 1.06 ENST00000234111.9
ODC1
ornithine decarboxylase 1
chr8_+_32548267 1.04 ENST00000356819.7
NRG1
neuregulin 1
chr7_+_28685968 1.02 ENST00000396298.6
CREB5
cAMP responsive element binding protein 5
chr2_-_10447771 0.92 ENST00000405333.5
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr14_+_77458032 0.90 ENST00000535854.6
ENST00000555517.1
ENST00000216479.8
AHSA1
activator of HSP90 ATPase activity 1
chr14_+_72926377 0.90 ENST00000353777.7
ENST00000358377.7
ENST00000394234.6
ENST00000509153.5
ENST00000555042.5
DCAF4
DDB1 and CUL4 associated factor 4
chr11_+_6603708 0.88 ENST00000532063.5
ILK
integrin linked kinase
chr11_+_6603740 0.86 ENST00000537806.5
ENST00000420936.6
ENST00000299421.9
ENST00000528995.5
ENST00000396751.6
ILK
integrin linked kinase
chr19_-_55140922 0.84 ENST00000589745.5
TNNT1
troponin T1, slow skeletal type
chr5_+_177087412 0.83 ENST00000513166.1
FGFR4
fibroblast growth factor receptor 4
chr21_+_33230375 0.81 ENST00000447980.1
IFNAR2
interferon alpha and beta receptor subunit 2
chr18_+_58045642 0.80 ENST00000676223.1
ENST00000675147.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr5_+_173144442 0.79 ENST00000231668.13
ENST00000351486.10
ENST00000352523.10
ENST00000393770.4
BNIP1
BCL2 interacting protein 1
chr18_+_58196736 0.77 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr21_+_41370452 0.76 ENST00000680862.1
MX2
MX dynamin like GTPase 2
chr16_-_57536543 0.75 ENST00000258214.3
CCDC102A
coiled-coil domain containing 102A
chr12_-_47904986 0.73 ENST00000549336.6
VDR
vitamin D receptor
chr8_+_98117285 0.72 ENST00000401707.7
ENST00000522319.5
POP1
POP1 homolog, ribonuclease P/MRP subunit
chr18_+_58045683 0.69 ENST00000592846.5
ENST00000675801.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_-_111503622 0.65 ENST00000369716.9
ENST00000241356.5
TMIGD3
ADORA3
transmembrane and immunoglobulin domain containing 3
adenosine A3 receptor
chr7_-_100896123 0.64 ENST00000428317.7
ACHE
acetylcholinesterase (Cartwright blood group)
chr15_-_101277287 0.63 ENST00000528346.1
ENST00000531964.5
ENST00000398226.7
ENST00000526049.6
SELENOS
selenoprotein S
chr21_+_33230073 0.63 ENST00000342101.7
ENST00000413881.5
ENST00000443073.5
IFNAR2
interferon alpha and beta receptor subunit 2
chr20_-_45912047 0.61 ENST00000477313.5
ENST00000354050.8
ENST00000372431.8
ENST00000420868.2
PLTP
phospholipid transfer protein
chr6_-_136550407 0.60 ENST00000354570.8
MAP7
microtubule associated protein 7
chr3_-_48301577 0.57 ENST00000451657.6
NME6
NME/NM23 nucleoside diphosphate kinase 6
chr6_-_136550819 0.56 ENST00000616617.4
ENST00000618822.4
MAP7
microtubule associated protein 7
chr18_+_580367 0.56 ENST00000327228.5
CETN1
centrin 1
chr17_-_8079903 0.56 ENST00000649809.1
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chr20_+_23350755 0.55 ENST00000254998.3
NXT1
nuclear transport factor 2 like export factor 1
chr19_-_5719849 0.54 ENST00000590729.5
LONP1
lon peptidase 1, mitochondrial
chr17_-_10697501 0.52 ENST00000577427.1
ENST00000255390.10
SCO1
synthesis of cytochrome C oxidase 1
chr22_-_43015133 0.51 ENST00000453643.5
ENST00000263246.8
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_228181669 0.50 ENST00000392056.8
SPHKAP
SPHK1 interactor, AKAP domain containing
chr7_-_920884 0.50 ENST00000617043.4
ENST00000437486.5
ADAP1
ArfGAP with dual PH domains 1
chr6_-_5260883 0.50 ENST00000330636.9
LYRM4
LYR motif containing 4
chr15_-_74695987 0.50 ENST00000563009.5
ENST00000568176.5
ENST00000566243.5
ENST00000566219.1
ENST00000426797.7
ENST00000315127.9
ENST00000566119.5
EDC3
enhancer of mRNA decapping 3
chr2_-_228181612 0.50 ENST00000344657.5
SPHKAP
SPHK1 interactor, AKAP domain containing
chr9_+_127802858 0.49 ENST00000393706.6
ENST00000630236.2
ENST00000373247.7
ENST00000373228.5
FPGS
folylpolyglutamate synthase
chr22_-_50085331 0.47 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr6_+_69866546 0.47 ENST00000620364.5
COL19A1
collagen type XIX alpha 1 chain
chr19_-_5720131 0.44 ENST00000587365.1
ENST00000360614.8
ENST00000585374.5
LONP1
lon peptidase 1, mitochondrial
chr19_-_5720159 0.44 ENST00000593119.5
LONP1
lon peptidase 1, mitochondrial
chr21_+_32412648 0.43 ENST00000401402.7
ENST00000382699.7
ENST00000300255.7
EVA1C
eva-1 homolog C
chr11_+_60842095 0.42 ENST00000227520.10
CCDC86
coiled-coil domain containing 86
chr14_+_92923143 0.41 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr9_+_127803208 0.40 ENST00000373225.7
ENST00000431857.5
FPGS
folylpolyglutamate synthase
chr8_+_11284789 0.40 ENST00000221086.8
MTMR9
myotubularin related protein 9
chr19_+_17933001 0.38 ENST00000445755.7
CCDC124
coiled-coil domain containing 124
chr6_-_5260730 0.38 ENST00000464010.5
ENST00000500576.4
ENST00000468929.5
ENST00000480566.5
LYRM4
LYR motif containing 4
chr4_+_15681683 0.37 ENST00000504137.1
FAM200B
family with sequence similarity 200 member B
chr6_+_13615322 0.36 ENST00000451315.7
NOL7
nucleolar protein 7
chr15_-_74695936 0.35 ENST00000647659.1
ENST00000566828.5
EDC3
enhancer of mRNA decapping 3
chr6_-_36874783 0.34 ENST00000373699.6
PPIL1
peptidylprolyl isomerase like 1
chr17_-_76737321 0.33 ENST00000359995.10
ENST00000508921.7
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
SRSF2
serine and arginine rich splicing factor 2
chr6_+_36442985 0.33 ENST00000373731.7
ENST00000483557.5
ENST00000498267.5
ENST00000449081.6
ENST00000460983.1
KCTD20
potassium channel tetramerization domain containing 20
chr1_-_206921987 0.30 ENST00000530505.1
ENST00000442471.4
FCMR
Fc fragment of IgM receptor
chr1_-_171652675 0.29 ENST00000037502.11
MYOC
myocilin
chr1_+_43979877 0.28 ENST00000356836.10
ENST00000309519.8
B4GALT2
beta-1,4-galactosyltransferase 2
chr1_-_43172244 0.27 ENST00000236051.3
EBNA1BP2
EBNA1 binding protein 2
chr11_-_6603571 0.27 ENST00000534343.1
ENST00000254605.11
RRP8
ribosomal RNA processing 8
chr2_+_206765578 0.26 ENST00000403094.3
ENST00000402774.8
FASTKD2
FAST kinase domains 2
chrX_+_54530182 0.25 ENST00000674498.1
GNL3L
G protein nucleolar 3 like
chr8_+_54135203 0.25 ENST00000260102.9
ENST00000519831.5
MRPL15
mitochondrial ribosomal protein L15
chr20_+_63861498 0.25 ENST00000369916.5
ABHD16B
abhydrolase domain containing 16B
chrX_+_129906146 0.25 ENST00000394422.8
UTP14A
UTP14A small subunit processome component
chr17_+_42659264 0.25 ENST00000251412.8
TUBG2
tubulin gamma 2
chr1_-_43172504 0.25 ENST00000431635.6
EBNA1BP2
EBNA1 binding protein 2
chr7_+_98211431 0.23 ENST00000609256.2
BHLHA15
basic helix-loop-helix family member a15
chr12_-_54648356 0.23 ENST00000293371.11
ENST00000456047.2
DCD
dermcidin
chr7_+_148133684 0.22 ENST00000628930.2
CNTNAP2
contactin associated protein 2
chr3_-_51499950 0.21 ENST00000423656.5
ENST00000504652.5
ENST00000684031.1
DCAF1
DDB1 and CUL4 associated factor 1
chr16_+_68264501 0.21 ENST00000618043.4
ENST00000219343.11
ENST00000566834.5
ENST00000566454.5
SLC7A6
solute carrier family 7 member 6
chr8_-_11853470 0.21 ENST00000679121.1
CTSB
cathepsin B
chr19_+_1285859 0.20 ENST00000215368.4
EFNA2
ephrin A2
chr11_-_65859282 0.20 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
CFL1
cofilin 1
chr17_+_36949285 0.20 ENST00000681062.1
ENST00000679881.1
ENST00000680782.1
AATF
apoptosis antagonizing transcription factor
chr22_-_30591850 0.19 ENST00000335214.8
ENST00000406208.7
ENST00000402284.7
ENST00000354694.12
PES1
pescadillo ribosomal biogenesis factor 1
chr17_-_3668557 0.19 ENST00000225525.4
TAX1BP3
Tax1 binding protein 3
chr1_+_20139316 0.19 ENST00000375102.4
PLA2G2F
phospholipase A2 group IIF
chr1_-_231241090 0.18 ENST00000451322.1
C1orf131
chromosome 1 open reading frame 131
chrX_+_129906118 0.18 ENST00000425117.6
UTP14A
UTP14A small subunit processome component
chr1_+_119414931 0.17 ENST00000543831.5
ENST00000433745.5
ENST00000369416.4
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr17_+_21376321 0.17 ENST00000583088.6
KCNJ12
potassium inwardly rectifying channel subfamily J member 12
chr22_-_30557586 0.17 ENST00000338911.6
ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_117929720 0.17 ENST00000369441.7
ENST00000349139.6
WDR3
WD repeat domain 3
chr3_-_179071742 0.16 ENST00000311417.7
ENST00000652290.1
ZMAT3
zinc finger matrin-type 3
chr11_+_60327250 0.15 ENST00000684409.1
MS4A6E
membrane spanning 4-domains A6E
chr14_+_22226711 0.15 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr1_-_193105373 0.14 ENST00000367439.8
GLRX2
glutaredoxin 2
chr22_-_37849296 0.14 ENST00000609454.5
ANKRD54
ankyrin repeat domain 54
chr8_-_30912998 0.14 ENST00000643185.2
TEX15
testis expressed 15, meiosis and synapsis associated
chr1_+_48222685 0.14 ENST00000533824.5
ENST00000236495.9
ENST00000438567.7
SLC5A9
solute carrier family 5 member 9
chr5_-_145835330 0.14 ENST00000394450.6
ENST00000683046.1
PRELID2
PRELI domain containing 2
chrX_+_55075062 0.14 ENST00000374974.7
PAGE2B
PAGE family member 2B
chr21_+_36699100 0.13 ENST00000290399.11
SIM2
SIM bHLH transcription factor 2
chr5_-_137754327 0.12 ENST00000314940.7
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr21_-_43659460 0.12 ENST00000443485.1
ENST00000291560.7
HSF2BP
heat shock transcription factor 2 binding protein
chr19_+_45406630 0.11 ENST00000309424.8
POLR1G
RNA polymerase I subunit G
chr19_+_16661121 0.11 ENST00000187762.7
ENST00000599479.1
TMEM38A
transmembrane protein 38A
chr1_+_43172324 0.11 ENST00000528956.5
ENST00000610710.4
ENST00000372492.9
ENST00000529956.5
CFAP57
cilia and flagella associated protein 57
chrX_+_55075023 0.11 ENST00000374971.2
PAGE2B
PAGE family member 2B
chr1_-_15585015 0.11 ENST00000375826.4
AGMAT
agmatinase
chr9_-_136363695 0.09 ENST00000371739.3
ENST00000371738.4
DNLZ
DNL-type zinc finger
chr1_-_85708382 0.09 ENST00000370574.4
ENST00000431532.6
ZNHIT6
zinc finger HIT-type containing 6
chr1_+_7771263 0.09 ENST00000054666.11
VAMP3
vesicle associated membrane protein 3
chr19_+_57670242 0.07 ENST00000612521.1
ZSCAN4
zinc finger and SCAN domain containing 4
chr8_+_108443601 0.07 ENST00000524143.5
ENST00000220853.8
EMC2
ER membrane protein complex subunit 2
chr3_+_111859736 0.07 ENST00000478922.1
ENST00000477695.5
PHLDB2
pleckstrin homology like domain family B member 2
chr3_+_174859315 0.07 ENST00000454872.6
NAALADL2
N-acetylated alpha-linked acidic dipeptidase like 2
chr17_-_7290392 0.07 ENST00000571464.1
YBX2
Y-box binding protein 2
chr16_+_19718264 0.06 ENST00000564186.5
IQCK
IQ motif containing K
chrX_+_54530201 0.06 ENST00000674225.1
ENST00000336470.8
ENST00000360845.3
ENST00000674238.1
ENST00000674420.1
ENST00000674311.1
ENST00000674508.1
GNL3L
G protein nucleolar 3 like
chr4_+_41981745 0.06 ENST00000333141.7
DCAF4L1
DDB1 and CUL4 associated factor 4 like 1
chr17_+_38752731 0.05 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr16_-_4847265 0.05 ENST00000591451.5
ENST00000436648.9
ENST00000321919.14
ENST00000588297.5
GLYR1
glyoxylate reductase 1 homolog
chr12_-_6568256 0.05 ENST00000382421.7
ENST00000545200.5
ENST00000399466.6
ENST00000322166.10
ENST00000536124.5
ENST00000540228.1
ENST00000542867.5
ENST00000545492.5
ENST00000545915.5
ENST00000620535.4
ENST00000617555.4
NOP2
NOP2 nucleolar protein
chr12_-_54280087 0.05 ENST00000209875.9
CBX5
chromobox 5
chrX_-_47659128 0.04 ENST00000333119.7
ENST00000335890.3
UXT
ubiquitously expressed prefoldin like chaperone
chr2_+_102619531 0.04 ENST00000233969.3
SLC9A2
solute carrier family 9 member A2
chr17_-_8163522 0.04 ENST00000404970.3
VAMP2
vesicle associated membrane protein 2
chr1_+_206897435 0.03 ENST00000391929.7
ENST00000294984.7
ENST00000611909.4
ENST00000367093.3
IL24
interleukin 24
chr17_-_63773534 0.02 ENST00000403162.7
ENST00000582252.1
ENST00000225726.10
CCDC47
coiled-coil domain containing 47
chr10_-_95656643 0.02 ENST00000371221.3
ENST00000371224.7
ALDH18A1
aldehyde dehydrogenase 18 family member A1
chr2_+_73926826 0.02 ENST00000629438.2
ENST00000348222.3
ENST00000264093.9
DGUOK
deoxyguanosine kinase
chr4_+_56435730 0.02 ENST00000514888.5
ENST00000264221.6
ENST00000505164.5
PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.7 2.1 GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
0.5 3.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.5 1.4 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.4 2.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.4 5.1 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 0.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 0.6 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 2.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 0.7 GO:0060058 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1 0.4 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.1 0.6 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 0.7 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.8 GO:1903412 response to bile acid(GO:1903412)
0.1 0.6 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.8 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 1.7 GO:0071280 cellular response to copper ion(GO:0071280)
0.1 0.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.6 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 1.0 GO:0072584 caveolin-mediated endocytosis(GO:0072584)
0.1 2.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 1.7 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.2 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.0 0.7 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.2 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.0 0.3 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.2 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.5 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:1904816 positive regulation of protein homodimerization activity(GO:0090073) positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.1 GO:0042262 DNA protection(GO:0042262)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 0.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 5.0 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.5 GO:0033647 host cell cytoplasm(GO:0030430) host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) host cell cytoplasm part(GO:0033655)
0.0 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.6 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 3.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.7 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.3 GO:0005771 multivesicular body(GO:0005771)
0.0 1.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 9.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.4 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.3 2.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.4 GO:0004905 type I interferon receptor activity(GO:0004905)
0.3 4.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 0.7 GO:1902271 D3 vitamins binding(GO:1902271)
0.2 0.6 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.6 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 2.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.8 GO:0031014 troponin T binding(GO:0031014)
0.1 0.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 3.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 9.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.5 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.8 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.0 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 3.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 2.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors