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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for BRCA1

Z-value: 0.18

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
ENSG00000012048.23 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43125450_43125493-0.501.1e-02Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_+_84181630 0.31 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr8_-_80171106 0.29 ENST00000519303.6
tumor protein D52
chr2_+_108378176 0.26 ENST00000409309.3
sulfotransferase family 1C member 4
chr2_+_108377947 0.24 ENST00000272452.7
sulfotransferase family 1C member 4
chr18_+_44697118 0.23 ENST00000677077.1
SET binding protein 1
chr17_-_43661915 0.21 ENST00000318579.9
ENST00000393661.2
mesenchyme homeobox 1
chr7_+_100119607 0.18 ENST00000262932.5
canopy FGF signaling regulator 4
chr1_-_160262501 0.15 ENST00000447377.5
DDB1 and CUL4 associated factor 8
chr1_-_160262522 0.15 ENST00000440682.5
DDB1 and CUL4 associated factor 8
chr11_+_73308237 0.12 ENST00000263674.4
Rho guanine nucleotide exchange factor 17
chr13_-_51974775 0.12 ENST00000674147.1
ATPase copper transporting beta
chr2_+_203014721 0.10 ENST00000683091.1
neurobeachin like 1
chr2_+_203014842 0.09 ENST00000683969.1
ENST00000449802.5
neurobeachin like 1
chr4_-_48780242 0.09 ENST00000507711.5
ENST00000358350.9
FRY like transcription coactivator
chr11_+_33258304 0.09 ENST00000531504.5
ENST00000456517.2
homeodomain interacting protein kinase 3
chr14_+_22040576 0.08 ENST00000390448.3
T cell receptor alpha variable 20
chr20_+_58907981 0.08 ENST00000656419.1
GNAS complex locus
chr19_+_45467988 0.08 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FosB proto-oncogene, AP-1 transcription factor subunit
chr12_-_95116967 0.08 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr10_+_47322450 0.08 ENST00000581492.3
growth differentiation factor 2
chrX_+_10156960 0.07 ENST00000380833.9
chloride voltage-gated channel 4
chrX_-_10833643 0.07 ENST00000380785.5
ENST00000380787.5
midline 1
chr20_+_33161768 0.07 ENST00000253362.6
BPI fold containing family A member 2
chr12_-_122395422 0.06 ENST00000540304.6
CAP-Gly domain containing linker protein 1
chr10_-_73625951 0.06 ENST00000433394.1
ENST00000422491.7
ubiquitin specific peptidase 54
chr19_+_48469354 0.06 ENST00000452733.7
ENST00000641098.1
cytohesin 2
chrX_-_71068384 0.06 ENST00000276105.3
ENST00000622259.4
sorting nexin 12
chr14_+_102592611 0.06 ENST00000262241.7
REST corepressor 1
chr19_-_12801787 0.05 ENST00000334482.9
ENST00000301522.3
peroxiredoxin 2
chr2_-_151261839 0.05 ENST00000331426.6
RNA binding motif protein 43
chr11_-_72112750 0.05 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
anaphase promoting complex subunit 15
chr14_+_63761836 0.04 ENST00000674003.1
spectrin repeat containing nuclear envelope protein 2
chr8_-_17002327 0.04 ENST00000180166.6
fibroblast growth factor 20
chr8_+_22165140 0.04 ENST00000397814.7
ENST00000354870.5
bone morphogenetic protein 1
chr14_-_94476211 0.04 ENST00000298845.12
serpin family A member 9
chr13_+_29428709 0.04 ENST00000542829.1
microtubule associated scaffold protein 2
chr1_-_160262407 0.04 ENST00000419626.1
ENST00000610139.5
ENST00000475733.5
ENST00000407642.6
ENST00000368073.7
ENST00000326837.6
DDB1 and CUL4 associated factor 8
chr14_-_94476190 0.04 ENST00000674397.2
ENST00000448305.6
serpin family A member 9
chr11_+_118077009 0.03 ENST00000616579.4
ENST00000534111.5
transmembrane serine protease 4
chr12_-_80937918 0.03 ENST00000552864.6
lin-7 homolog A, crumbs cell polarity complex component
chr1_-_160262540 0.03 ENST00000368074.6
DDB1 and CUL4 associated factor 8
chr6_-_158999748 0.03 ENST00000449822.5
radial spoke head 3
chr1_-_17045219 0.03 ENST00000491274.5
succinate dehydrogenase complex iron sulfur subunit B
chr7_-_100119323 0.03 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chr10_-_49269 0.03 ENST00000562809.1
ENST00000568866.5
ENST00000561967.1
ENST00000568584.6
tubulin beta 8 class VIII
chr2_+_135741814 0.03 ENST00000272638.14
UBX domain protein 4
chr9_-_21031614 0.03 ENST00000495827.3
3-hydroxyacyl-CoA dehydratase 4
chr2_-_49973939 0.03 ENST00000630656.1
neurexin 1
chr5_+_154941063 0.03 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
mitochondrial ribosomal protein L22
chr1_+_161766282 0.03 ENST00000680688.1
activating transcription factor 6
chr2_-_157325808 0.02 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ermin
chr4_+_625555 0.02 ENST00000496514.6
ENST00000255622.10
phosphodiesterase 6B
chr9_-_92424427 0.02 ENST00000375550.5
osteomodulin
chr3_+_184338826 0.02 ENST00000453072.5
family with sequence similarity 131 member A
chr11_+_118077067 0.02 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
transmembrane serine protease 4
chr11_-_61430008 0.02 ENST00000394888.8
cleavage and polyadenylation specific factor 7
chr19_+_46347063 0.02 ENST00000012443.9
ENST00000391919.1
protein phosphatase 5 catalytic subunit
chr14_+_20190896 0.02 ENST00000641879.2
ENST00000641682.1
olfactory receptor family 11 subfamily G member 2
chr8_+_22165358 0.01 ENST00000306349.13
ENST00000306385.10
bone morphogenetic protein 1
chr5_+_146203544 0.01 ENST00000506502.2
novel readthrough transcript
chr16_-_740980 0.01 ENST00000251588.7
cytosolic iron-sulfur assembly component 3
chr16_-_740934 0.01 ENST00000540986.5
cytosolic iron-sulfur assembly component 3
chr6_-_43014254 0.01 ENST00000642748.1
male-enhanced antigen 1
chr20_-_35438218 0.01 ENST00000374369.8
growth differentiation factor 5
chrX_-_71068311 0.01 ENST00000374274.8
sorting nexin 12
chr6_-_170553216 0.01 ENST00000262193.7
proteasome 20S subunit beta 1
chr12_-_95942592 0.01 ENST00000546947.5
ENST00000344280.8
ENST00000546386.1
coiled-coil domain containing 38
chr2_-_144517663 0.01 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr11_+_101914997 0.01 ENST00000263468.13
centrosomal protein 126
chr1_+_160177386 0.01 ENST00000470705.1
ATPase Na+/K+ transporting subunit alpha 4
chr19_+_55675191 0.01 ENST00000270460.11
ENST00000085079.11
epsin 1
chr19_-_37172670 0.01 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
zinc finger protein 585A
chr2_+_98087160 0.01 ENST00000477737.6
von Willebrand factor A domain containing 3B
chr12_-_24562438 0.01 ENST00000646273.1
ENST00000659413.1
ENST00000446891.7
SRY-box transcription factor 5
chrX_-_77895414 0.01 ENST00000618282.5
ENST00000373336.3
magnesium transporter 1
chr11_-_61429934 0.01 ENST00000541963.5
ENST00000477890.6
ENST00000439958.8
cleavage and polyadenylation specific factor 7
chr6_+_33204645 0.01 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr12_-_116881062 0.00 ENST00000550505.5
harakiri, BCL2 interacting protein
chrX_-_77895546 0.00 ENST00000358075.11
magnesium transporter 1
chr17_+_38752731 0.00 ENST00000619426.5
ENST00000610434.4
proteasome 20S subunit beta 3
chr14_-_59630806 0.00 ENST00000342503.8
reticulon 1
chr1_-_41242106 0.00 ENST00000337495.9
ENST00000372597.5
ENST00000372596.5
Scm polycomb group protein homolog 1
chr10_+_91923762 0.00 ENST00000265990.11
B-TFIID TATA-box binding protein associated factor 1
chr13_+_27251545 0.00 ENST00000311549.11
ribosomal protein L21
chr4_+_109827963 0.00 ENST00000317735.7
retinal pigment epithelium-derived rhodopsin homolog
chr6_+_16129077 0.00 ENST00000356840.8
ENST00000349606.4
myosin regulatory light chain interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.0 0.1 GO:0060003 copper ion export(GO:0060003)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules