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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for CDX1
Z-value: 0.93
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Transcription factors associated with CDX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDX1 | hg38_v1_chr5_+_150166770_150166788, hg38_v1_chr5_+_150166790_150166890 | -0.28 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.3 | 4.0 | GO:0035878 | nail development(GO:0035878) |
| 0.3 | 2.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 1.8 | GO:0072189 | ureter development(GO:0072189) |
| 0.6 | 1.7 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.0 | 1.6 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.4 | 1.5 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.0 | 1.3 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.4 | 1.2 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.2 | 1.2 | GO:1904499 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 2.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 2.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.2 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 1.2 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.1 | 0.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.9 | GO:0032982 | myosin filament(GO:0032982) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.9 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 2.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 1.7 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 0.0 | 1.6 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 1.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.4 | 1.2 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.1 | 1.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.2 | 1.1 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.1 | 1.0 | GO:0033691 | sialic acid binding(GO:0033691) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.8 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 0.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 1.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.6 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 1.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 1.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 0.9 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.0 | 0.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |