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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for CEBPA
Z-value: 1.57
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg38_v1_chr19_-_33302524_33302542 | -0.10 | 6.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102798148 Show fit | 14.91 |
ENST00000315274.7
|
matrix metallopeptidase 1 |
|
| chr1_+_100719734 Show fit | 9.39 |
ENST00000370119.8
ENST00000294728.7 ENST00000347652.6 ENST00000370115.1 |
vascular cell adhesion molecule 1 |
|
| chr15_+_88638947 Show fit | 8.83 |
ENST00000559876.2
|
interferon stimulated exonuclease gene 20 |
|
| chr15_+_88639009 Show fit | 7.39 |
ENST00000306072.10
|
interferon stimulated exonuclease gene 20 |
|
| chr14_+_103121457 Show fit | 6.96 |
ENST00000333007.8
|
TNF alpha induced protein 2 |
|
| chr2_+_102104563 Show fit | 6.72 |
ENST00000409589.5
ENST00000409329.5 |
interleukin 1 receptor type 1 |
|
| chr21_+_42199686 Show fit | 6.36 |
ENST00000398457.6
|
ATP binding cassette subfamily G member 1 |
|
| chr3_-_127736329 Show fit | 6.28 |
ENST00000398101.7
|
monoglyceride lipase |
|
| chr4_+_73740541 Show fit | 6.24 |
ENST00000401931.1
ENST00000307407.8 |
C-X-C motif chemokine ligand 8 |
|
| chr1_-_173050931 Show fit | 6.20 |
ENST00000404377.5
|
TNF superfamily member 18 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.2 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 15.3 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.6 | 13.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 1.3 | 9.4 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 1.7 | 8.5 | GO:0032730 | positive regulation of interleukin-1 alpha production(GO:0032730) |
| 0.2 | 8.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 2.2 | 6.7 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 2.1 | 6.4 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.4 | 6.4 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.7 | 6.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 15.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 14.2 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 12.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 11.0 | GO:0043296 | apical junction complex(GO:0043296) |
| 3.1 | 9.4 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 7.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 6.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 5.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.4 | 4.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 16.2 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 15.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 10.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.9 | 9.4 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 8.9 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.0 | 7.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 1.7 | 6.7 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 1.6 | 6.4 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.3 | 6.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.3 | 6.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 15.8 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.5 | 15.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 14.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 14.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 9.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 7.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.9 | 4.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 14.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 14.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 9.3 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 8.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 6.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 6.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 5.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 5.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |