Project
Inflammatory response time course, HUVEC (Wada, 2009)
Navigation
Downloads
Results for CEBPB
Z-value: 1.72
Motif logo
Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg38_v1_chr20_+_50190821_50190839 | 0.55 | 4.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_88638947 Show fit | 14.85 |
ENST00000559876.2
|
interferon stimulated exonuclease gene 20 |
|
| chr15_+_88639009 Show fit | 12.58 |
ENST00000306072.10
|
interferon stimulated exonuclease gene 20 |
|
| chr1_+_212608628 Show fit | 11.05 |
ENST00000613954.4
ENST00000341491.9 ENST00000366985.5 |
activating transcription factor 3 |
|
| chr4_-_138242325 Show fit | 10.42 |
ENST00000280612.9
|
solute carrier family 7 member 11 |
|
| chr11_-_102798148 Show fit | 9.57 |
ENST00000315274.7
|
matrix metallopeptidase 1 |
|
| chr5_-_151093566 Show fit | 9.53 |
ENST00000521001.1
|
TNFAIP3 interacting protein 1 |
|
| chr15_-_79971164 Show fit | 8.95 |
ENST00000335661.6
ENST00000267953.4 ENST00000677151.1 |
BCL2 related protein A1 |
|
| chr5_-_142325001 Show fit | 7.84 |
ENST00000344120.4
ENST00000434127.3 |
sprouty RTK signaling antagonist 4 |
|
| chr6_+_32844789 Show fit | 6.80 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
|
| chr6_+_127577168 Show fit | 6.42 |
ENST00000329722.8
|
chromosome 6 open reading frame 58 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 27.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 3.7 | 11.1 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.3 | 10.4 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.2 | 9.6 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 3.2 | 9.5 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 9.3 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.2 | 8.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 7.6 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
| 0.0 | 6.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.6 | 6.2 | GO:0001554 | luteolysis(GO:0001554) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 13.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 3.9 | 11.7 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 11.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 10.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.2 | 9.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 8.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 8.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 7.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.7 | 4.7 | GO:1990037 | Lewy body core(GO:1990037) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 27.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 20.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 15.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 9.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.4 | 8.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 1.5 | 7.7 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.4 | 6.7 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 6.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.8 | 6.5 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 5.3 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 10.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 8.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 8.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 5.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 4.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 19.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 16.3 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.4 | 10.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 7.8 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.4 | 6.7 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 4.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 3.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.9 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.2 | 2.6 | REACTOME SIGNALING BY NOTCH3 | Genes involved in Signaling by NOTCH3 |