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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for CEBPG
Z-value: 0.60
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Transcription factors associated with CEBPG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPG | hg38_v1_chr19_+_33373694_33373826, hg38_v1_chr19_+_33374312_33374348 | 0.58 | 2.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_88638947 Show fit | 4.23 |
ENST00000559876.2
|
interferon stimulated exonuclease gene 20 |
|
| chr15_+_88639009 Show fit | 3.64 |
ENST00000306072.10
|
interferon stimulated exonuclease gene 20 |
|
| chr14_+_103121457 Show fit | 3.22 |
ENST00000333007.8
|
TNF alpha induced protein 2 |
|
| chr11_-_102798148 Show fit | 3.19 |
ENST00000315274.7
|
matrix metallopeptidase 1 |
|
| chr21_+_42199686 Show fit | 2.97 |
ENST00000398457.6
|
ATP binding cassette subfamily G member 1 |
|
| chrX_+_1336585 Show fit | 2.00 |
ENST00000381469.7
|
interleukin 3 receptor subunit alpha |
|
| chr2_+_102104563 Show fit | 1.98 |
ENST00000409589.5
ENST00000409329.5 |
interleukin 1 receptor type 1 |
|
| chr9_+_113150991 Show fit | 1.94 |
ENST00000259392.8
|
solute carrier family 31 member 2 |
|
| chr5_-_122078249 Show fit | 1.80 |
ENST00000231004.5
|
lysyl oxidase |
|
| chr5_+_126423176 Show fit | 1.53 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 7.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 3.4 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.2 | 3.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 1.0 | 3.0 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.1 | 2.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.7 | 2.0 | GO:0038156 | interleukin-3-mediated signaling pathway(GO:0038156) |
| 0.7 | 2.0 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.2 | 1.9 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.4 | 1.8 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.2 | 1.8 | GO:0048251 | elastic fiber assembly(GO:0048251) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 4.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 4.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 3.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 2.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.5 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.5 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 3.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 3.2 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.7 | 3.0 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.7 | 2.0 | GO:0004912 | interleukin-3 receptor activity(GO:0004912) |
| 0.5 | 2.0 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.2 | 1.9 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.3 | 1.8 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 1.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 1.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.7 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 2.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 2.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.0 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |